Boxe4Ageing: Boxing Training, Cognitive Performance, and Physical-functional Fitness in Older Adults
Study Details
Study Description
Brief Summary
The aim of the study is to evaluate and to compare the effects of two exercise regime (Boxing Training -BT and Multicomponent Training -MT) on cognitive health status, physical-functional fitness, and risk of falls in community-dwelling elders.
This is a quasi-experimental controlled trial using a parallel-group design. Participants will be allocated in one 3 groups (i.e., BT, MT or control group [no intervention]). Both exercise programs (BT and MT) will last 24 weeks, twice a week, 45 minutes per session. In some assessments, the participants of exercise groups will be evaluated at 3 time points (baseline, after 12 and 24 weeks). Participants from the Control Group will participate in the assessments (initial [baseline] and final [24 weeks]).
Our hypotheses are:
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In comparison with the control group, both exercise regimes groups (BT and MT) will positively impact on cognitive health status, physical-functional fitness, and risk of falls in community-dwelling elders.
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The observed effects on cognitive health status, physical-functional fitness, and risk of falls as a result of the BT program will be superior to the effects arisen from the MT exercise regime.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
Aging is associated with functional and cognitive decline (1, 2), which are causal factors of falls in the elderly. According to available evidence, alleviation of these conditions can be achieved through regular exercise of the multicomponent type (MT) (3). However, in TM programs, "muscle power" takes a secondary role (5) although it is extremely important to preserve the integrity of the neuromuscular system (6). Studies indicate that combat sports may represent an exercise strategy that combines muscular fitness, cardiorespiratory fitness, agility, and balance (7), in addition to falling within the scope of dual-task programs (i.e., physical and cognitive) because they require memorization of combinations of attacking and defending movements, quick decision-making, and movement by coordinating simultaneous leg and hand movements (8). Seminal work with adapted boxing for elderly parkinsonians has demonstrated positive results in health indicators (9, 10). But the effectiveness of this modality in apparently healthy elderly is still unknown. Therefore, this project aims to compare the effects of boxing training and multi-component training on cognitive performance, physical-functional fitness and the risk of falls in older people.
The study comprises a quantitative quasi-experimental design, will be conducted in the metropolitan area of Porto, Portugal. The study sample will consist of healthy individuals from the community, aged ≥ 60 years, who will be recruited in community programs, municipalities, health centers, and social media platforms through phone calls and informational flyers. Those who accept to participate will be informed about the project objectives and procedures. Participation will be voluntary, and everyone will be required to sign the Free and Informed Consent form.
Participants will be allocated into intervention groups: (Boxing training group or Multicomponent training group) or the Control Group (No intervention). The main results will be the cognitive performance evaluated by neurocognitive and psychological tests, in addition to brain activity by means of the electroencephalogram (EEG), physical-functional fitness measured through the Senior Fitness test, Cosmed K5b2, Handgrip strength, ball throw, isokinetic strength and the risk of falls evaluated by the Biodex® Balance System. Secondary outcomes will be body composition, bone mineral density, quality of life and satisfaction with exercise.
The research protocol will follow the CONSORT guidelines.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Experimental group 1 (adapted boxing) Experimental boxing - The general structure of adapted boxing will include a 10-minute warm-up consisting of walking at a slow, self-selected speed, and at the same time joint rotation exercises; followed by 25-30 minutes of adapted boxing (consisting of non-contact activities, distributed in coordination and balance/footwork, shadow boxing-choreography (sequence of arm and leg movements that simulate an imaginary fight and punching bag), to end the session there will be a content fixation exercise, relaxation with gentle movements and breathing for 5 -10 minutes. |
Other: Boxing training
Training protocol will be held for 24 weeks, twice per week/ 45 min per sessions.
Other Names:
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| Active Comparator: Experimental group 2 (multi-component training) Sessions will be divided in 10 minutes warm-up (including slow walk, postural and mobility exercises for general activation, and stretching exercises), specific training (25-30 minutes, including balance/coordination training, strength, and aerobic exercises) and cool down 5 - 10 minutes (breathing and stretching exercises for the main worked joints and muscles) following the main guidelines recommended by the American College of Sports Medicine (4) and the WHO (3). |
Other: Exercise
Training protocol will be held for 24 weeks, twice per week/ 45 min per sessions.
Other Names:
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| No Intervention: Control group Participants from the control group will participate in assessments (initial and final) and will be asked to maintain their usual activities. At the end of the intervention period, the control group will be invited to participate in a physical activity program that takes place at the University. |
Outcome Measures
Primary Outcome Measures
- Change from Baseline cognitive performance (Memory) at 6 months [Baseline, 6 months]
Consortium to establish a registry for the Alzheimer's Disease List Test (CERAD), will be used: word list memory; word list recall; and word list recognition. The parameters: total hits and delayed recall hits (13, 14).
- Change from Baseline cognitive performance (Selective recall test) at 6 months [Baseline, 6 months]
Selective recall test [SRT-List A; parameters: consistent long-term recall, long-term storage, delayed recall, and intrusions] to assess verbal learning and multiple-trial memory (14).
- Change from Baseline cognitive performance (Verbal short-term memory and verbal working memory) at 6 months [Baseline, 6 months]
The forward digit advancement (DS) test was selected to assess verbal short-term memory and the backward DS to assess verbal working memory (subtest of the Wechsler test of intelligence for adults WAIS III) and total DS score (total DS; calculated by adding forward DS and backward DS) (14, 16).
- Change from Baseline cognitive performance (Inhibition/cognitive flexibility) at 6 months [Baseline, 6 months]
The Stroop Color and Word Test (parameters: words, colors, and words/colors) will be selected to assess response inhibition/cognitive flexibility (14).
- Change from Baseline cognitive performance (Processing speed) at 6 months [Baseline, 6 months]
Digit Symbol Substitution Test (DSST, subtest of the Wechsler test of adult intelligence WAIS III) (16, 17) will be used as a measure of high-level information processing speed.
- Change from Baseline Psychological testing (Depression) at 6 months [Baseline, 6 months]
The geriatric depression scale (GDS, short version) (18) will be used for depressive symptoms assessment. The GDS-15 evaluates depressive symptoms during the last week and has a dichotomous response scale (Yes/No). On 10 items (2, 3, 4, 6, 8, 9, 10, 12, 14, 15) the answer Yes is rated 1 point and on the remaining items (1, 5, 7, 11, and 13) the answer No is rated 1 point, in the sense that the score indicates presence of depressive symptomatology. The total score of the items is processed by summing the scores on the 15 items, ranging from 0 to 15 points. The 15-item version of the GDS showed the ability to differentiate depressed from nondepressed subjects (18).
- Change from Baseline Psychological testing (Anxiety and depression) at 6 months [Baseline, 6 months]
Hospital Anxiety and Depression Scale (HADS) will be used (19). Although the HADS is considered an effective instrument for assessing depressive symptoms in hospital settings, it is a screening measure, and it is of utmost importance to be followed by a psychological assessment. This scale consists of two subscales, one for anxiety and the other for depression. A score between 0 to 7 means absence of depressive or anxious symptoms; a score between 8 to 10 means a possible case of depression or anxiety; and from 11 to 21 as a probable case.
- Change from Baseline Psychological testing (Stress) at 6 months [Baseline, 6 months]
Perceived Stress Scale (PSS-10) (20) will be used to assess perceived stress.
- Change from Baseline Brain Activity at 6 months [Baseline, 6 months]
This will be analyzed using an electromyography (EEG) system. All EEG signals will be acquired with the ActiCHamp®, Brain Products,GmbH. With an international 10-20 system with standard 32-channel electrode layout with reference and ground electrodes. The ground will be located on the forehead and the reference will be the Cz channel of the ActiCHamp® equipment. For each participant, the same equipment will be used in all sessions.
- Change from Baseline peak oxygen uptake (VO2 peak) at 6 months [Baseline, 6 months]
Modified Bruce Treadmill Test - This sub-maximal test with incremental protocol including seven stages and performed on a treadmill, standard an open-circuit spirometer technique (Cosmed K5b2, Cosmed, Rome, Italy) will be used.
- Change from Baseline Lower-body strength and power at 6 months [Baseline, 6 months]
The knee extensors and flexors will be evaluated using an isokinetic dynamometer (Biodex System 2, USA) at two different angular velocities: 60°/s and 180°/s (22).
- Change from Baseline Physical-Functional Fitness (strength of the lower and upper body) at 6 months [Baseline, 6 months]
Physical-functional fitness is going to be measured via the Senior Fitness Test (SFT) (23). This physical battery includes lower and upper-body strength (30-second chair stand and 30-second arm curl tests, respectively), agility/dynamic balance (8-foot up-and-go test), aerobic endurance (six-minute walk test) and lower and upper-body flexibility (chair sit-and-reach and back scratch tests, respectively). The chair stand test to assess the strength of the lower body, counting the number of repetitions made in 30s. And the arm curl test to assess the strength on the upper body, using a 3lb (women) and 5lb (men) dumbbell, counting the number of repetitions made in 30s.
- Change from baseline Physical-Functional Fitness (8-Foot Up and Go Test) at 6 months [Baseline, 6 months]
Physical-functional fitness is going to be measured via the Senior Fitness Test (SFT) (23). This physical battery includes lower and upper-body strength (30-second chair stand and 30-second arm curl tests, respectively), agility/dynamic balance (8-foot up-and-go test), aerobic endurance (six-minute walk test) and lower and upper-body flexibility (chair sit-and-reach and back scratch tests, respectively). The stand up, walk 8-foot distance (2,44 meters), turn the cone marker around and return to the seated position. The time, in seconds, necessary to complete this test will be registered.
- Change from baseline Physical-Functional Fitness (six-minute walk test) at 6 months [Baseline, 6 months]
Physical-functional fitness is going to be measured via the Senior Fitness Test (SFT) (23). This physical battery includes lower and upper-body strength (30-second chair stand and 30-second arm curl tests, respectively), agility/dynamic balance (8-foot up-and-go test), aerobic endurance (six-minute walk test) and lower and upper-body flexibility (chair sit-and-reach and back scratch tests, respectively). The participants walk as fast as possible (without running) around the course as many times as they can within the time limit (6 minutes).
- Change from baseline Physical-Functional Fitness (flexibility of the lower and upper-body) at 6 months [Baseline, 6 months]
Physical-functional fitness is going to be measured via the Senior Fitness Test (SFT) (23). This physical battery includes lower and upper-body strength (30-second chair stand and 30-second arm curl tests, respectively), agility/dynamic balance (8-foot up-and-go test), aerobic endurance (six-minute walk test) and lower and upper-body flexibility (chair sit-and-reach and back scratch tests, respectively). The chair sit-&-reach test to assess the flexibility of the lower-body, measured in cm. And The back scratch test to assess flexibility on the upper-body, measured in cm.
- Change from baseline on Risk of Falls at 6 months [Baseline, 6 months]
Risk of falls will be evaluated through the Biodex® Balance System (Biodex, Shirley, NY, EUA), using the Fall Risk Test protocol in which the platform is unstable and allows to obtain the risk index and modified version of the Clinical Test of Sensory Interaction and Balance (CTSIB).
- Change from baseline on Handgrip strength at 3 months and at 6 months, respectively. [Baseline, 3 months, 6 months]
The handgrip strength will be measured with a Jamar Plus + Digital hand dynamometer (Sammons Preston Inc., Bolingbrook, Illinois, USA). Measurements will be carried out following the American Society of Hand Therapists recommendations, and each participant will perform three attempts with a pause of 1 min between them. Three attempts will be made for each hand, using the maximum value of the three registers.
- Change from baseline Upper Body Power at 3 months and at 6 months, respectively. [Baseline, 3 months, 6 months]
This will be tested with a 3 kg (Ø 0.60 m) medical ball. Each subject will sit in a chair with the posterior region of the trunk positioned against the back of the chair and hold the ball forward with both hands. Three approved trials will be conducted with one-minute rest intervals between each trial to ensure that fatigue or learning effects do not influence performance. The maximum throwing distance will be determined using a flexible steel tape. Only the best attempt will be used for further analysis (24).
Secondary Outcome Measures
- Sociodemographic Assessments are going to measured at baseline. [Baseline]
Age (years), academic level (primary, secondary, bachelor, master, PhD), civil status (married, separated, widow, single, others), number of medications, diagnosed diseases, falls in the last 6 and 12 months.
- Change from Baseline body mass, fat-free mass, fat mass at 3 months and at 6 months, respectively [Baseline, 3 months, 6 months]
Body mass (kg), fat-free mass (kg) and fat mass (kg) will be analyzed with bioimpedance (InBody 120®).
- Change from Baseline Appendicular Skeletal Muscle Mass Index at 6 months [Baseline, 6 months]
Appendicular Skeletal Muscle Mass Index (ASMI), which is the sum of muscle masses of the four limbs described as appendicular skeletal muscle mass adjusted for height (kg/m2), will be analyzed with Dual Energy X-ray Absorptiometry (DXA).
- Change from Baseline Bone Mineral Density at 6 months [Baseline, 6 months]
They will be analyzed by Dual Energy X-ray Absorptiometry (DXA).
- Change from baseline Quality of Life at 6 months [Baseline, 6 months]
Quality of life will be tested with the World Health Organization Quality of Life Assessment Tool (WHOQOL-Bref).
- Exercise satisfaction [6 months]
Will be tested with the physical activity enjoyment scale (PACES) (26). The Portuguese version of the PACES is a validated and reliable instrument to assess enjoyment in group fitness activities. This scale is composed of eight items (e.g., "It is invigorating") preceded by the statement "The physical activity I practice..." to which participants respond through a Likert-type scale with a minimum score of 1 "totally disagree" and maximum score of 7 ("totally agree").
Other Outcome Measures
- Change from baseline Daily Physical Activity levels at 6 months [Baseline, 6 months]
Daily physical activity will be collected with the activity monitors GT3X+ (ActiGraph). Devices are going to be placed on participant´s waist, to measure the activity intensity (counts per minute) during one week. Is addition, physical activity will be also self reportedwith the IPAQ short version (IPAQ-SV).
- Change from Baseline on Daily Physical Activity levels [baseline up to 24 weeks]
Self reported physical activity will be assessed with the IPAQ short form (IPAQ-SF).
- Change from baseline Caloric Intake at 6 months [Baseline, 6 months]
Caloric intake will be evaluated by a 4-day food record. Macronutrients (i.e., carbohydrate, protein, and fat) will be analyzed as a percentage of total calories consumed.
- Change from baseline Sarcopenia at 6 months [Baseline, 6 months]
Sarcopenia will be evaluated according to the consensus of the European Working Group on Sarcopenia in Older Persons (EWGSOP2).
- Change from baseline Frailty Phenotype at 6 months [Baseline, 6 months.]
Frailty Phenotype will be assessed according to a study that defines the presence of frailty based on at least three of five criteria: unintentional weight loss, weakness, slow gait, self-reported exhaustion, and low physical activity.
- Exercise intensity [6 months, during the intervention]
Borg Rating of Perceived Exertion
- Applicability of the interventions [6 months during the intervention]
Adverse events, discomfort or chest pain during training will be measured with the Borg Category ratio scale (CR-10).
Eligibility Criteria
Criteria
Inclusion Criteria:
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Male or female participants aged ≥60 years;
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Community-dwelling older adults;
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Do not present any medical contraindication for physical activity;
Exclusion Criteria:
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Individuals diagnosed with certain disorders or conditions in which exercise is contraindicated such as unstable or ongoing cardiovascular and/or respiratory disorders;
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Presence of major neurological and Neurocognitive disorders (Portuguese version of the Montreal Cognitive Assessment - MoCA) (12);
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Universidade do Porto
- Fundação para a Ciência e a Tecnologia
Investigators
- Principal Investigator: Lucimere Bohn, PhD, Universidade do Porto
- Principal Investigator: Kessketlen Miranda, PhD student, Universidade do Porto
Study Documents (Full-Text)
None provided.More Information
Publications
- Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, Carty C, Chaput JP, Chastin S, Chou R, Dempsey PC, DiPietro L, Ekelund U, Firth J, Friedenreich CM, Garcia L, Gichu M, Jago R, Katzmarzyk PT, Lambert E, Leitzmann M, Milton K, Ortega FB, Ranasinghe C, Stamatakis E, Tiedemann A, Troiano RP, van der Ploeg HP, Wari V, Willumsen JF. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020 Dec;54(24):1451-1462. doi: 10.1136/bjsports-2020-102955.
- Combs SA, Diehl MD, Staples WH, Conn L, Davis K, Lewis N, Schaneman K. Boxing training for patients with Parkinson disease: a case series. Phys Ther. 2011 Jan;91(1):132-42. doi: 10.2522/ptj.20100142. Epub 2010 Nov 18.
- Domingos J, Radder D, Riggare S, Godinho C, Dean J, Graziano M, de Vries NM, Ferreira J, Bloem BR. Implementation of a Community-Based Exercise Program for Parkinson Patients: Using Boxing as an Example. J Parkinsons Dis. 2019;9(3):615-623. doi: 10.3233/JPD-191616.
- Hill NL, Bhargava S, Brown MJ, Kim H, Bhang I, Mullin K, Phillips K, Mogle J. Cognitive complaints in age-related chronic conditions: A systematic review. PLoS One. 2021 Jul 7;16(7):e0253795. doi: 10.1371/journal.pone.0253795. eCollection 2021.
- Hunter SK, Pereira HM, Keenan KG. The aging neuromuscular system and motor performance. J Appl Physiol (1985). 2016 Oct 1;121(4):982-995. doi: 10.1152/japplphysiol.00475.2016. Epub 2016 Aug 11.
- Origua Rios S, Marks J, Estevan I, Barnett LM. Health benefits of hard martial arts in adults: a systematic review. J Sports Sci. 2018 Jul;36(14):1614-1622. doi: 10.1080/02640414.2017.1406297. Epub 2017 Nov 21.
- Santos-Eggimann B, Sirven N. Screening for frailty: older populations and older individuals. Public Health Rev. 2016 Aug 22;37:7. doi: 10.1186/s40985-016-0021-8. eCollection 2016.
- Shearin S, Braitsch M, Querry R. The effect of a multi-modal boxing exercise program on cognitive locomotor tasks and gait in persons with Parkinson disease. NeuroRehabilitation. 2021;49(4):619-627. doi: 10.3233/NRE-210218.
- Streit IA, Pinto SS, Silva ADS, Bezerra ES. Body weight multicomponent program improves power and functional capacity responses in older adults: A quasi-experimental study. Exp Gerontol. 2021 Nov;155:111553. doi: 10.1016/j.exger.2021.111553. Epub 2021 Sep 14.
- Thompson PD, Arena R, Riebe D, Pescatello LS; American College of Sports Medicine. ACSM's new preparticipation health screening recommendations from ACSM's guidelines for exercise testing and prescription, ninth edition. Curr Sports Med Rep. 2013 Jul-Aug;12(4):215-7. doi: 10.1249/JSR.0b013e31829a68cf. No abstract available.
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