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Cerebrovascular Response to Acute Exercise

Sponsor
University of Wisconsin, Madison (Other)
Overall Status
Completed
CT.gov ID
NCT03722953
Collaborator
(none)
18
Enrollment
1
Location
1
Arm
15.2
Actual Duration (Months)
1.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Condition or Disease Intervention/Treatment Phase
  • Other: Control
  • Other: Aerobic Exercise
 N/A

Detailed Description

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

  1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function

  2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.

  3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Study Design

Study Type:
Interventional
Actual Enrollment :
18 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise
Actual Study Start Date :
Dec 1, 2018
Actual Primary Completion Date :
Mar 9, 2020
Actual Study Completion Date :
Mar 9, 2020

Arms and Interventions

Arm Intervention/Treatment
Other: Aerobic Exercise

Control: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.

Other: Control
Ultrasound Blood Pressure Heart Rate Oxygen Saturation

Other: Aerobic Exercise
Ultrasound Blood Pressure Heart Rate Oxygen Saturation

Outcome Measures

Primary Outcome Measures

  1. Cerebrovascular function [Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.]

    Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test

  2. Peripheral vascular function [Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.]

    Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years to 40 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Between 20-40 years old

  • BMI < 30 kg/m2

  • Recreationally active

  • Experience running on a treadmill

Exclusion Criteria:

  • Current smoker

  • History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes

  • Taking blood pressure medication

  • History of depression or other mood related disorders

  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Contacts and Locations

Locations

Site City State Country Postal Code
1 Gymnasium-Natatorium Madison Wisconsin United States 53706

Sponsors and Collaborators

  • University of Wisconsin, Madison

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
University of Wisconsin, Madison
ClinicalTrials.gov Identifier:
NCT03722953
Other Study ID Numbers:
  • 2018-0783
  • A176000
  • EDUC/KINESIOLOGY
  • Protocol Version 10/23/2018
First Posted:
Oct 29, 2018
Last Update Posted:
Jun 22, 2022
Last Verified:
Jun 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by University of Wisconsin, Madison
Exercise
Treadmill
Vascular Function
Intensity

Study Results

No Results Posted as of Jun 22, 2022