Investigation of the Relationship Between Taste Perception and Caries Activity in School Children

Sponsor
University of Beykent (Other)
Overall Status
Completed
CT.gov ID
NCT03468946
Collaborator
(none)
200
3
19

Study Details

Study Description

Brief Summary

Four basic taste perceptions and relationship with caries are poorly investigated in children as compared to adults.

The aim of this study was to evaluate salty, sweet, bitter and sour taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors.

Condition or Disease Intervention/Treatment Phase
  • Other: salty taste perception
  • Other: bitter taste perception
  • Other: sour taste perception
  • Other: sweet taste perception
N/A

Detailed Description

Study design

  1. Caries risk assessment The investigators developed a questionnaire to understand the patient's overall health status, to collect demographic and socio-economic information, to assess their oral health habits. The questionnaire consists of 3 parts; first part includes questions about general health such as chronic diseases, drugs and allergies, second part includes questions about income and education level of parents, and last part includes questions about oral health knowledge, habits, diet contents and frequency, fluoride exposure. the investigators allowed the parents to fill the questionnaire.

After the questionnaire was filled, the investigators performed the oral examination using DMFT, DMFS, dft and dfs indices according to WHO. Then, the investigators determined the oral hygiene status with Sillness&Löe Index (Silness ve Loe, 1964). the investigators estimated paraffin-stimulated salivary flow rate, buffer capacity, mutans streptococci and lactobacilli counts using CRT chairside kits (Ivoclar Vivadent, Schaan, Liechtenstein).

In addition to initial questionnaire and oral examination, the investigators asked the patients to record their nutritional takings of 2 weekdays and 1 weekend day. the investigators estimated the caries risk profiles of all children using the Cariogram which is a computer-based program. Cariogram identifies three risk groups low, medium and high caries risk according the scores.

  1. Taste evaluation the investigators prepared aqueous basic taste solutions of sucrose (Merck, Germany, purity >99.5%), sodium chloride (Sigma-Aldrich, USA, purity >99%), caffeine (Merck, Germany, purity >99.5%), citric acid monohydrate (Sigma-Aldrich, USA, purity >99%), at two levels (1.0 ISO, 2.0 ISO) (ISO 3972:1991, 8586-1:1993) (Table 1). the investigators formulated all the solutions by using spring water in the same day of measurement at room temperature (25 ± 2°C). Each solution was coded randomly.

Study Design

Study Type:
Interventional
Actual Enrollment :
200 participants
Allocation:
Non-Randomized
Intervention Model:
Parallel Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose:
Diagnostic
Official Title:
Investigation of the Relationship Between Taste Perception and Caries Activity in School Children
Actual Study Start Date :
May 2, 2013
Actual Primary Completion Date :
May 1, 2014
Actual Study Completion Date :
Dec 1, 2014

Arms and Interventions

Arm Intervention/Treatment
Other: high caries risk

children with high caries -identified by cariogram to evaluate sweet taste perception, salty taste perception, sour taste perception and bitter taste perception of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors.

Other: salty taste perception
salty taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate salty taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors(high caries risk, medium caries risk, low risk ).
Other Names:
  • sodium chloride
  • Sigma-Aldrich, USA
  • RIEDEL SK.S.314
  • Other: bitter taste perception
    bitter taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate bitter taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • caffeine
  • Merck, Germany
  • MERCK 102584
  • Other: sour taste perception
    sour taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sour taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • citric acid
  • Sigma-Aldrich, USA
  • RIEDEL SK.R.2 7102
  • Other: sweet taste perception
    sweet taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sweet taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • sucrose
  • Merck, Germany
  • MERCK 1.07651.1 000
  • Other: medium caries risk

    children with medium caries- identified by cariogram to evaluate sweet taste perception, salty taste perception, sour taste perception and bitter taste perception of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors.

    Other: salty taste perception
    salty taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate salty taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors(high caries risk, medium caries risk, low risk ).
    Other Names:
  • sodium chloride
  • Sigma-Aldrich, USA
  • RIEDEL SK.S.314
  • Other: bitter taste perception
    bitter taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate bitter taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • caffeine
  • Merck, Germany
  • MERCK 102584
  • Other: sour taste perception
    sour taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sour taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • citric acid
  • Sigma-Aldrich, USA
  • RIEDEL SK.R.2 7102
  • Other: sweet taste perception
    sweet taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sweet taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • sucrose
  • Merck, Germany
  • MERCK 1.07651.1 000
  • Other: low risk

    no caries or low risk- identified by cariogram to evaluate sweet taste perception, salty taste perception, sour taste perception and bitter taste perception of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors.

    Other: salty taste perception
    salty taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate salty taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors(high caries risk, medium caries risk, low risk ).
    Other Names:
  • sodium chloride
  • Sigma-Aldrich, USA
  • RIEDEL SK.S.314
  • Other: bitter taste perception
    bitter taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate bitter taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • caffeine
  • Merck, Germany
  • MERCK 102584
  • Other: sour taste perception
    sour taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sour taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • citric acid
  • Sigma-Aldrich, USA
  • RIEDEL SK.R.2 7102
  • Other: sweet taste perception
    sweet taste perception in high caries risk, medium caries risk, low caries risk. The aim of this study was to evaluate sweet taste perceptions of school children and compare them with demographic, clinical, microbiologic and biochemical caries-risk factors (high caries risk, medium caries risk, low risk ).
    Other Names:
  • sucrose
  • Merck, Germany
  • MERCK 1.07651.1 000
  • Outcome Measures

    Primary Outcome Measures

    1. DMFT, DMFS, dft and dfs indices [1 year]

      DMFT, DMFS, dft and dfs indices are total counts of decayed, missing, filled teeth / DMFT, Plaque index, Salivary flow rate, buffer capacity, mutans streptococci and lactobacilli counts are combined to report caries risk in high/medium/low caries risk

    Secondary Outcome Measures

    1. Sillness&Löe Index [1 year]

      Sillness&Löe index in total amount of dental plaque on the teeth. /DMFT, Plaque index, Salivary flow rate, buffer capacity, mutans streptococci and lactobacilli counts are combined to report caries risk in high/medium/low caries risk

    2. Salivary flow rate [1 year]

      Salivary flow rate in ml/minute

    3. buffer capacity [1 year]

      buffer capacity in pH / DMFT, Plaque index, Salivary flow rate, buffer capacity, mutans streptococci

    4. mutans streptococci and lactobacilli counts [1 year]

      mutans streptococci and lactobacilli counts in cfu/ml / DMFT, Plaque index, Salivary flow

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    6 Years to 13 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • without any chronic disease such as diabetes and being ASA I or ASA II. We only included patients who had no antibiotics and drug intake within the last month.
    Exclusion Criteria:
    • chronic disease ASA III, IV antibiotic and drug intake within the last month

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • University of Beykent

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Edibe Egil, Assistant Professor, University of Beykent
    ClinicalTrials.gov Identifier:
    NCT03468946
    Other Study ID Numbers:
    • SAG-C-DRP-090414-0077
    First Posted:
    Mar 19, 2018
    Last Update Posted:
    Mar 19, 2018
    Last Verified:
    Mar 1, 2018
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Edibe Egil, Assistant Professor, University of Beykent
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Mar 19, 2018