CORTEX: Role of the Posterior Parietal Cortex in the Processing of Sensory Information

Sponsor

University Hospital, Lille (Other)

Overall Status

Unknown status

CT.gov ID

NCT03386188

Collaborator

(none)

Enrollment

Location

Arm

66.5

Duration (Months)

0.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Condition or Disease	Intervention/Treatment	Phase
Healthy Subject	Device: Transcranial Magnetic Stimulation (TMS) Device: Electrical Muscle Activity (EMG)	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

20 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Role of the Posterior Parietal Cortex in the Processing of Sensory Information Modulating the Excitability of the Primary Motor Cortex in Humans

Study Start Date :

Jan 1, 2016

Anticipated Primary Completion Date :

Jan 18, 2021

Anticipated Study Completion Date :

Jul 18, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Healthy arm posterior parietal cortex (PPC) transitory inactivation	Device: Transcranial Magnetic Stimulation (TMS) Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration. Device: Electrical Muscle Activity (EMG) Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Arm

Intervention/Treatment

Experimental: Healthy arm

posterior parietal cortex (PPC) transitory inactivation

Device: Transcranial Magnetic Stimulation (TMS)

Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.

Device: Electrical Muscle Activity (EMG)

Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Outcome Measures

Primary Outcome Measures

Afferent induced facilitation [Baseline]
Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms

Secondary Outcome Measures

Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI) [Baseline]
Effect of median nerve stimulation on LICI at 100ms interval

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Right handed
No neurological troubles
Informed consent signed
Affiliated to a social security

Exclusion Criteria:

Psychiatric antecedent
Neurological disease
Contra-indication to TMS
Under psychiatric treatment
Pregnancy
Contra-indication to MRI

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hôpital Roger Salengro, CHRU de Lille	Lille		France

Sponsors and Collaborators

University Hospital, Lille

Investigators

Principal Investigator: Philippe Derambure, MD, PhD, University Hospital, Lille

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University Hospital, Lille

ClinicalTrials.gov Identifier:

NCT03386188

Other Study ID Numbers:

2014_32
2014-A01507-40

First Posted:

Dec 29, 2017

Last Update Posted:

Aug 25, 2020

Last Verified:

Aug 1, 2020

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Study Results

No Results Posted as of Aug 25, 2020