Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects
Study Details
Study Description
Brief Summary
The beneficial effect of daytime sleep on memory consolidation has been shown in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during daytime SWS.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: SHAM stimulation SHAM stimulation during periods of Slow Wave Sleep |
Device: no stimulation
sham Stimulation
|
Experimental: 0,75 Hz stimulation slow transcranial oscillating stimulation (~0,75Hz) during periods of Slow Wave Sleep |
Device: brain stimulation
oscillating direct current brain stimulation
|
Outcome Measures
Primary Outcome Measures
- Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS [4 weeks]
Retention between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.
Secondary Outcome Measures
- Amount of Slow wave Sleep [4 weeks]
1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.
- 2. sleep spindles [4 weeks]
2. Spindle activity during sleep indicated via several spindle parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.
- 3. EEG-correlates [4 weeks]
3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).
- 4. further memory systems [4 weeks]
4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
healthy Subjects
-
unobtrusive, neuropsychological screening
-
age: 18-35 years
-
right handed
Exclusion Criteria:
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untreated severe internal or psychiatric diseases
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epilepsy
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other severe neurological diseases eg., previous major stroke, brain tumour
-
contraindications to MRI
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Charite CCM Neurologie Berlin | Berlin | Germany | 10117 |
Sponsors and Collaborators
- Charite University, Berlin, Germany
Investigators
- Principal Investigator: Agnes Flöel, Professor, Charite Universitätsmedizin Berlin - Neurologie
Study Documents (Full-Text)
None provided.More Information
Publications
- Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. Review.
- Mander BA, Santhanam S, Saletin JM, Walker MP. Wake deterioration and sleep restoration of human learning. Curr Biol. 2011 Mar 8;21(5):R183-4. doi: 10.1016/j.cub.2011.01.019.
- Marshall L, Helgadóttir H, Mölle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. Epub 2006 Nov 5.
- Mednick S, Nakayama K, Stickgold R. Sleep-dependent learning: a nap is as good as a night. Nat Neurosci. 2003 Jul;6(7):697-8.
- Mednick SC, Cai DJ, Kanady J, Drummond SP. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi: 10.1016/j.bbr.2008.04.028. Epub 2008 May 8.
- Nap-tSOS-young