Comparison of Vascular Effects After Therapy With Irbesartan and Atorvastatin.

• Sponsor: Technische Universität Dresden (Other)
• Overall Status: Completed
• CT.gov ID: NCT00154024
• Collaborator: (none)
• Location: 1
• Duration (Months): 43

Study Details

Study Description

Brief Summary

Vascular responses to angiotensin II and histamine are compared before and after 30 days of systemic treatment with either irbesartan 150 mg or atorvastatin 20 mg.

Condition or Disease	Intervention/Treatment	Phase
Healthy Subjects	Drug: atorvastatin; Drug: irbesartan	N/A

Detailed Description

Vascular responses to angiotensin II and histamine are compared before and after 30 days of systemic treatment with either irbesartan 150 mg or atorvastatin 20 mg.

Study Design

• Study Type: Interventional
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Double
• Primary Purpose: Treatment
• Official Title: Characterization of Local Vascular Effects of Angiotensin II and Histamine After Treatment With Irbesartan and Atorvastatin.
• Study Start Date: Mar 1, 2003
• Study Completion Date: Oct 1, 2006

Outcome Measures

Primary Outcome Measures

1. vascular responses after treatment. []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 45 Years
• Sexes Eligible for Study: Male
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• healthy subjects

• no relevant disease

• amendment: hypercholesterolaemic subjects

Exclusion Criteria:

• any relevant disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Institute of Clinical Pharmacology, Medical Faculty, University of Technology	Dresden		Germany	01307

Sponsors and Collaborators

• Technische Universität Dresden

Investigators

• Study Chair: Wilhelm Kirch, MD, Institute of Clinical Pharmacology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00154024
• Other Study ID Numbers: IKPD 03-02
• First Posted: Sep 12, 2005
• Last Update Posted: Sep 28, 2006
• Last Verified: Jul 1, 2006

• Keywords provided by , ,: venoconstriction; venodilation; pleiotropic effects
• Additional relevant MeSH terms: Irbesartan; Atorvastatin

Study Results

No Results Posted as of Sep 28, 2006