Endothelial Dysfunction Induced by Postprandial Lipemia
Sponsor
Norwegian University of Science and Technology (Other)
Overall Status
Completed
CT.gov ID
NCT00660491
Collaborator
(none)
8
1
3
9
0.9
Study Details
Study Description
Brief Summary
Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.
Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Study Design
Study Type:
Interventional
Actual Enrollment
:
8 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Double (Participant, Care Provider)
Primary Purpose:
Treatment
Official Title:
Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise
Study Start Date
:
Jan 1, 2008
Actual Primary Completion Date
:
Sep 1, 2008
Actual Study Completion Date
:
Oct 1, 2008
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Intervention: 1 Control |
|
| No Intervention: 2 moderate exercise training group |
|
| Experimental: 3 high intensity exercise group |
Other: exercise training
moderate intensity exercise group, and high intensity exercise group
|
Outcome Measures
Primary Outcome Measures
- Flow mediated dilatation [baseline, post exercise, 30min, 2hour, 4hour post exercise]
Secondary Outcome Measures
- blood lipid profile [same as flow mediated dilatation]
Eligibility Criteria
Criteria
Ages Eligible for Study:
20 Years
to 40 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
- male, 20-40years, BMI between 25 and 30, resident in Trondheim.
Exclusion Criteria:
- unstable angina, CHD, heart failure,
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | NTNU | Trondheim | Norway | 7489 |
Sponsors and Collaborators
- Norwegian University of Science and Technology
Investigators
- Study Chair: Ulrik Wisloff, Professor, National Taiwan Normal University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:
NCT00660491
Other Study ID Numbers:
- Exercise, Food and Endothelium
First Posted:
Apr 17, 2008
Last Update Posted:
Jan 6, 2012
Last Verified:
Jan 1, 2012
Keywords provided by Norwegian University of Science and Technology
Additional relevant MeSH terms: