Vitamin D in Healthy Adults After Strenuous Endurance Exercise
Study Details
Study Description
Brief Summary
The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Vitamin D group
|
Dietary Supplement: Vitamin D
Participants received 5,000 IU of vitamin D orally twice daily for 4 weeks
Other Names:
|
| Placebo Comparator: Placebo group
|
Dietary Supplement: Medium-chain triglycerides
Participants received the same amount of placebo matching vitamin D orally twice daily for 4 weeks
|
Outcome Measures
Primary Outcome Measures
- Concentration of Neutrophil [before exercise]
- Concentration ofNeutrophil [immediately after exercise]
- Concentration of Neutrophil [2-hour after exercise]
- Concentration of Neutrophil [4-hour after exercise]
- Concentration of Neutrophil [8-hour after exercise]
- Concentration of Neutrophil [24-hour after exercise]
- Concentration of eosinophil [before exercise]
- Concentration of eosinophil [immediately after exercise]
- Concentration of eosinophil [2-hour after exercise]
- Concentration of eosinophil [4-hour after exercise]
- Concentration of eosinophil [8-hour after exercise]
- Concentration of eosinophil [24-hour after exercise]
- Concentration of basophil [before exercise]
- Concentration of basophil [immediately after exercise]
- Concentration of basophil [2-hour after exercise]
- Concentration of basophil [4-hour after exercise]
- Concentration of basophil [8-hour after exercise]
- Concentration of basophil [24-hour after exercise]
- Concentration of monocyte [before exercise]
- Concentration of monocyte [immediately after exercise]
- Concentration of monocyte [2-hour after exercise]
- Concentration of monocyte [4-hour after exercise]
- Concentration of monocyte [8-hour after exercise]
- Concentration of monocyte [24-hour after exercise]
- Concentration of lymphocyte [before exercise]
- Concentration of lymphocyte [immediately after exercise]
- Concentration of lymphocyte [2-hour after exercise]
- Concentration of lymphocyte [4-hour after exercise]
- Concentration of lymphocyte [8-hour after exercise]
- Concentration of lymphocyte [24-hour after exercise]
- Concentration of CD4+ [before exercise]
- Concentration of CD4+ [immediately after exercise]
- Concentration of CD4+ [2-hour after exercise]
- Concentration of CD4+ [4-hour after exercise]
- Concentration of CD4+ [8-hour after exercise]
- Concentration of CD4+ [24-hour after exercise]
- Concentration of CD8+ [before exercise]
- Concentration of CD8+ [immediately after exercise]
- Concentration of CD8+ [2-hour after exercise]
- Concentration of CD8+ [4-hour after exercise]
- Concentration of CD8+ [8-hour after exercise]
- Concentration of CD8+ [24-hour after exercise]
- Concentration of CD19+ [before exercise]
- Concentration of CD19+ [immediately after exercise]
- Concentration of CD19+ [2-hour after exercise]
- Concentration of CD19+ [4-hour after exercise]
- Concentration of CD19+ [8-hour after exercise]
- Concentration of CD19+ [24-hour after exercise]
- Concentration of CD56+ [before exercise]
- Concentration of CD56+ [immediately after exercise]
- Concentration of CD56+ [2-hour after exercise]
- Concentration of CD56+ [4-hour after exercise]
- Concentration of CD56+ [8-hour after exercise]
- Concentration of CD56+ [24-hour after exercise]
- Concentration of IgA [before exercise]
- Concentration of IgA [immediately after exercise]
- Concentration of IgA [2-hour after exercise]
- Concentration of IgA [4-hour after exercise]
- Concentration of IgA [8-hour after exercise]
- Concentration of IgA [24-hour after exercise]
- Concentration of Cathelicidin [before exercise]
- Concentration of Cathelicidin [immediately after exercise]
- Concentration of Cathelicidin [2-hour after exercise]
- Concentration of Cathelicidin [4-hour after exercise]
- Concentration of Cathelicidin [8-hour after exercise]
- Concentration of Cathelicidin [24-hour after exercise]
- Concentration of TNF-α [before exercise]
- Concentration of TNF-α [immediately after exercise]
- Concentration of TNF-α [2-hour after exercise]
- Concentration of TNF-α [4-hour after exercise]
- Concentration of TNF-α [8-hour after exercise]
- Concentration of TNF-α [24-hour after exercise]
- Concentration of IL-1β [before exercise]
- Concentration of IL-1β [immediately after exercise]
- Concentration of IL-1β [2-hour after exercise]
- Concentration of IL-1β [4-hour after exercise]
- Concentration of IL-1β [8-hour after exercise]
- Concentration of IL-1β [24-hour after exercise]
- Concentration of IFN-γ [before exercise]
- Concentration of IFN-γ [immediately after exercise]
- Concentration of IFN-γ [2-hour after exercise]
- Concentration of IFN-γ [4-hour after exercise]
- Concentration of IFN-γ [8-hour after exercise]
- Concentration of IFN-γ [24-hour after exercise]
- Concentration of IL-2 [before exercise]
- Concentration of IL-2 [immediately after exercise]
- Concentration of IL-2 [2-hour after exercise]
- Concentration of IL-2 [4-hour after exercise]
- Concentration of IL-2 [8-hour after exercise]
- Concentration of IL-2 [24-hour after exercise]
- Concentration of IL-4 [before exercise]
- Concentration of IL-4 [immediately after exercise]
- Concentration of IL-4 [2-hour after exercise]
- Concentration of IL-4 [4-hour after exercise]
- Concentration of IL-4 [8-hour after exercise]
- Concentration of IL-4 [24-hour after exercise]
- Concentration of IL-8 [before exercise]
- Concentration of IL-8 [immediately after exercise]
- Concentration of IL-8 [2-hour after exercise]
- Concentration of IL-8 [4-hour after exercise]
- Concentration of IL-8 [8-hour after exercise]
- Concentration of IL-8 [24-hour after exercise]
- Concentration of IL-10 [before exercise]
- Concentration of IL-10 [immediately after exercise]
- Concentration of IL-10 [2-hour after exercise]
- Concentration of IL-10 [4-hour after exercise]
- Concentration of IL-10 [8-hour after exercise]
- Concentration of IL-10 [24-hour after exercise]
- Concentration of TBARS [before exercise]
- Concentration of TBARS [immediately after exercise]
- Concentration of TBARS [2-hour after exercise]
- Concentration of TBARS [4-hour after exercise]
- Concentration of TBARS [8-hour after exercise]
- Concentration of TBARS [24-hour after exercise]
- Concentration of PC [before exercise]
- Concentration of PC [immediately after exercise]
- Concentration of PC [2-hour after exercise]
- Concentration of PC [4-hour after exercise]
- Concentration of PC [8-hour after exercise]
- Concentration of PC [24-hour after exercise]
- Concentration of SOD [before exercise]
- Concentration of SOD [immediately after exercise]
- Concentration of SOD [2-hour after exercise]
- Concentration of SOD [4-hour after exercise]
- Concentration of SOD [8-hour after exercise]
- Concentration of SOD [24-hour after exercise]
- Concentration of catalase [before exercise]
- Concentration of catalase [immediately after exercise]
- Concentration of catalase [2-hour after exercise]
- Concentration of catalase [4-hour after exercise]
- Concentration of catalase [8-hour after exercise]
- Concentration of catalase [24-hour after exercise]
- Concentration of GPx [before exercise]
- Concentration of GPx [immediately after exercise]
- Concentration of GPx [2-hour after exercise]
- Concentration of GPx [4-hour after exercise]
- Concentration of GPx [8-hour after exercise]
- Concentration of GPx [24-hour after exercise]
- Concentration of CK [before exercise]
- Concentration of CK [immediately after exercise]
- Concentration of CK [2-hour after exercise]
- Concentration of CK [4-hour after exercise]
- Concentration of CK [8-hour after exercise]
- Concentration of CK [24-hour after exercise]
- Concentration of LDH [before exercise]
- Concentration of LDH [immediately after exercise]
- Concentration of LDH [2-hour after exercise]
- Concentration of LDH [4-hour after exercise]
- Concentration of LDH [8-hour after exercise]
- Concentration of LDH [24-hour after exercise]
- Concentration of IL-6 [before exercise]
- Concentration of IL-6 [immediately after exercise]
- Concentration of IL-6 [2-hour after exercise]
- Concentration of IL-6 [4-hour after exercise]
- Concentration of IL-6 [8-hour after exercise]
- Concentration of IL-6 [24-hour after exercise]
- Concentration of CRP [before exercise]
- Concentration of CRP [immediately after exercise]
- Concentration of CRP [2-hour after exercise]
- Concentration of CRP [4-hour after exercise]
- Concentration of CRP [8-hour after exercise]
- Concentration of CRP [24-hour after exercise]
Eligibility Criteria
Criteria
Inclusion Criteria:
- The volunteers included have conditions as stated below :
-
no history of cardiovascular, liver, kidney and diabetes disease
-
no acute sport injury
-
male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min
-
did not participated in any clinical trials or research in the last 3 months before our experiment
-
no supplements were taken during the experimental period
-
were requested to maintain their regular daily life style and avoid alcohol intake
Exclusion Criteria:
- The volunteers were excluded if they have the situation stated below:
-
history of cardiovascular, liver, kidney and diabetes disease
-
acute sport injury
-
their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min
-
participated in any clinical trials or experimental research in the last 3 months before our experiment
-
taking supplement during the experimental period
-
did not maintain their regular eating habit or drink alcohol
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Taipei Medical University | Taipei | Taiwan | 110 |
Sponsors and Collaborators
- Taipei Medical University
- Panion & BF Biotech Inc.
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- N202010026
- A-107-077