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Interruption of Dorsal Visual Stream Using TMS

Sponsor
Sheba Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT00418652
Collaborator
(none)
12
Enrollment
1
Location
3
Arms

Study Details

Study Description

Brief Summary

Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

Condition or Disease Intervention/Treatment Phase
  • Device: No TMS intervention
  • Device: TMS over the PO3 EEG site
  • Device: TMS over the vertex
 N/A

Detailed Description

The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex.

First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures.

Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Study Design

Study Type:
Interventional
Actual Enrollment :
12 participants
Allocation:
Randomized
Intervention Model:
Single Group Assignment
Masking:
Single (Participant)
Primary Purpose:
Diagnostic
Official Title:
Interruption of Dorsal Visual Stream Using TMS in Normal Controls
Study Start Date :
Jan 1, 2006
Actual Primary Completion Date :
Jul 1, 2010

Arms and Interventions

Arm Intervention/Treatment
No Intervention: No TMS stimulation

The patients performed 2 tasks: a study and a control assignments with no TMS stimulation.

Device: No TMS intervention
In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.
Experimental: TMS over the dorsal stream

The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the dorsal stream area (PO3 EEG site).

Device: TMS over the PO3 EEG site
10Hz TMS over the dorsal stream (PO3 EEG site)
Other Names:
  • MAGSTIM biphasic stimulator

    		•
    Sham Comparator: TMS over the vertex

    The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the vertex area.

    Device: TMS over the vertex
    10Hz TMS for over vertex.
    Other Names:
  • MAGSTIM biphasic stimulator

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Results of the study assignments performed by the participants during the study. [The participants performed the tasks once during their study visit]

      The subjects performed 2 tasks: The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses. Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 65 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Normal controls
    Exclusion Criteria:

    • neurological, ophthalmological or psychiatric problems

    • family history of schizophrenia

    • left handed

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Psychiatry Clinic - Sheba Medical Center Tel-hashomer Israel 52621

    Sponsors and Collaborators

    • Sheba Medical Center

    Investigators

    • Principal Investigator: Revital Amiaz, MD, Sheba Medical Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00418652
    Other Study ID Numbers:
    • SHEBA-06-4252-RA-CTIL
    First Posted:
    Jan 5, 2007
    Last Update Posted:
    Aug 4, 2011
    Last Verified:
    Aug 1, 2011
    Keywords provided by , ,
    Normal Controls

    Study Results

    No Results Posted as of Aug 4, 2011