EnBiGen: Endophenotype Characterization of a Family Psychiatric Disorder

Sponsor

University Hospital, Grenoble (Other)

Overall Status

Unknown status

CT.gov ID

NCT02843997

Collaborator

(none)

Enrollment

Location

Arm

Duration (Months)

0.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.

The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.

Condition or Disease	Intervention/Treatment	Phase
Healthy Volunteer	Genetic: Endophenotype and sequencing	N/A

Detailed Description

Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.

The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

29 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Official Title:

Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression

Study Start Date :

Feb 1, 2015

Anticipated Primary Completion Date :

Feb 1, 2018

Anticipated Study Completion Date :

Feb 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Other: Healthy volunteers Members of a family	Genetic: Endophenotype and sequencing Draw an endophenotype and genetic study

Arm

Intervention/Treatment

Other: Healthy volunteers

Members of a family

Genetic: Endophenotype and sequencing

Draw an endophenotype and genetic study

Outcome Measures

Primary Outcome Measures

Neuropsychological evaluations tests [One day]
Neuropsychological evaluations (about one hour) : TMT (Trail Making Test) A and B, Stroop VFT (Visual Field Testing), DST (Dyslexia Screening Test) Tower of London test Hayling, CPT (continuous performance task) CVLT (California Verbal Learning Test) tests.
Eye tracking. [One hour]
The volunteer will follow an instruction according to the color seen on a screen. This instruction is to look at the side where there is a flashlight and to look at the opopsite if the light is unbroken. Mistakes will be count.
Blood sampling [3 minutes]
Genetic sample for extraction of DNA.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Members of a family adult (more than 18 years)
Signed informed consents
Registered to a French social security or possesor of the European Health Insurance Card

Exclusion Criteria:

Clinical part :

Refusal to sign the participation study consent.
Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.