MRI Study of Saccadic Adaptation

Sponsor

Hospices Civils de Lyon (Other)

Overall Status

Completed

CT.gov ID

NCT03488082

Collaborator

(none)

Enrollment

Location

Arm

Actual Duration (Months)

1.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections).

The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.

Condition or Disease	Intervention/Treatment	Phase
Healthy Volunteers	Behavioral: fMRI	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

36 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Coupling Between Saccadic Adaptation and Visuospatial Perception Process: MRI Study in Humans

Actual Study Start Date :

Oct 17, 2018

Actual Primary Completion Date :

Jul 17, 2020

Actual Study Completion Date :

Jul 17, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Measurement of the bold signal	Behavioral: fMRI saccadic adaptation (target presentations, with or without target jump) during fMRI exam

Arm

Intervention/Treatment

Experimental: Measurement of the bold signal

Behavioral: fMRI

saccadic adaptation (target presentations, with or without target jump) during fMRI exam

Outcome Measures

Primary Outcome Measures

BOLD signal [throughout the behavioral experiment at Day 1]
cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks).

Secondary Outcome Measures

Eye movements [during the development of saccadic adaptation (throughout the behavioral experiments at Day 1)]
measurement of the eye movements (saccades) of the subject while fixating and shifting gaze toward visual targets (behavioral tasks).

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Age: 18 to 40 years included,

Exclusion Criteria:

Known ophthalmological or neurological pathology,
Non-stabilized medical condition,
Taking psychotropic treatment,
No fluency in reading in French,
Pregnant and / or breastfeeding woman

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Inserm U1208	Bron		France	69500

Sponsors and Collaborators

Hospices Civils de Lyon

Investigators

Principal Investigator: Denis PELISSON, INSERM U1208

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Hospices Civils de Lyon

ClinicalTrials.gov Identifier:

NCT03488082

Other Study ID Numbers:

69HCL18_0200
2018-A00932-53

First Posted:

Apr 4, 2018

Last Update Posted:

Jan 12, 2022

Last Verified:

Jan 1, 2022

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Hospices Civils de Lyon

saccadic adaptation

visual-spatial perception

fMRI

Study Results

No Results Posted as of Jan 12, 2022