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Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

Sponsor
Sheffield Teaching Hospitals NHS Foundation Trust (Other)
Overall Status
Completed
CT.gov ID
NCT01235494
Collaborator
University of Sheffield (Other)
36
Enrollment
1
Location
1
Arm
126
Actual Duration (Months)
0.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Condition or Disease Intervention/Treatment Phase
  • Other: polarised 3 helium
 Phase 1

Study Design

Study Type:
Interventional
Actual Enrollment :
36 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas
Actual Study Start Date :
Jul 1, 2010
Actual Primary Completion Date :
Dec 31, 2020
Actual Study Completion Date :
Dec 31, 2020

Arms and Interventions

Arm Intervention/Treatment
Experimental: polarised 3 helium

inhaled gas

Other: polarised 3 helium
1 inhalation (= 1 litre)

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 70 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • age 18 -70
    Exclusion Criteria:

    • contraindication to MRI

    • Resting oxygen saturation <95%

    • Volunteers requiring bronchodilators less than 4 hourly

    • additional respiratory diagnoses

    • pregnancy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Academic Unit of Radiology, Univeristy of Sheffield Sheffield South Yorkshire United Kingdom S10 2SJ

    Sponsors and Collaborators

    • Sheffield Teaching Hospitals NHS Foundation Trust
    • University of Sheffield

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Sheffield Teaching Hospitals NHS Foundation Trust
    ClinicalTrials.gov Identifier:
    NCT01235494
    Other Study ID Numbers:
    • STH15080
    First Posted:
    Nov 5, 2010
    Last Update Posted:
    Dec 29, 2021
    Last Verified:
    Dec 1, 2021

    Study Results

    No Results Posted as of Dec 29, 2021