Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

• Sponsor: Washington University School of Medicine (Other)
• Overall Status: Completed
• CT.gov ID: NCT01752868
• Collaborator: Barnes-Jewish Hospital (Other)
• Enrollment: 56
• Location: 1
• Arms: 2
• Duration (Months): 15
• Patients Per Site Per Month: 3.7

Study Details

Study Description

Brief Summary

The purpose of this study is to determine if a combination of 10 nutritional supplements provide health benefits that are consistent with protection against age-related disease. All supplements have been shown in previous studies to have health benefits when administered alone. The hypothesis is that 6 months of taking 10 nutritional supplements each day will provide beneficial changes in healthy related measures.

Condition or Disease	Intervention/Treatment	Phase
Healthy Volunteers	Dietary Supplement: Supplement	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 56 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Prevention
• Official Title: Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?
• Study Start Date: May 1, 2011
• Actual Primary Completion Date: Aug 1, 2012
• Actual Study Completion Date: Aug 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: supplement	Dietary Supplement: Supplement; Participants in this group will take the following nutritional supplements on a daily basis: curcumin, fish oil, resveratrol, sesamin, Acetyl-L-carnitine, lipoic acid, green and black teas, quercetin, pomegranate, cinnamon bark.
No Intervention: control

Outcome Measures

Primary Outcome Measures

1. Carotid-femoral pulse wave velocity [Baseline and 6 months]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 40 Years to 60 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• age 40-60 yr

• body mass index of 21 - 30 kg/m2

• sedentary to moderately active

• eating a typical US diet

Exclusion Criteria:

• history of any chronic disease other than mild osteoarthritis

• use of medications other than occasional use of non-steroidal anti-inflammatory drugs, antihistamines, antacids or laxatives

• use of nutritional supplements

• smoking

• alcohol intake greater than two drinks per day for women and three drinks per day for men

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Washington University Medical Center	St. Louis	Missouri	United States	63110

Sponsors and Collaborators

• Washington University School of Medicine
• Barnes-Jewish Hospital

Investigators

• Principal Investigator: Luigi Fontana, MD, PhD, Washington University School of Medicine

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Washington University School of Medicine
• ClinicalTrials.gov Identifier: NCT01752868
• Other Study ID Numbers: BJH 6936-33
• First Posted: Dec 19, 2012
• Last Update Posted: Dec 19, 2012
• Last Verified: Dec 1, 2012

Study Results

No Results Posted as of Dec 19, 2012