The Anabolic and Catabolic Effect of Loaded and Unloaded Exercise on Articular Cartilage Health

Sponsor

University of Manitoba (Other)

Overall Status

Completed

CT.gov ID

NCT05925244

Collaborator

(none)

Enrollment

Location

Arms

5.1

Actual Duration (Months)

2.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The serum concentration of cartilage oligomeric matrix protein (sCOMP) has been considered a mechano-sensitive biomarker of articular cartilage turnover, and N-propeptide of type II collagen (PIIANP) is a proposed biomarker of type II collagen synthesis. Few studies have investigated both the anabolic and turnover response of articular cartilage as a result of acute changes in body weight mass during exercise. Using a repeated measures cross-over design, fifteen healthy adults (age 18-30 years) performed three, 30-minute bouts of treadmill walking exercise under 3 loading conditions: (1) control (no alteration to body mass); (2) loaded (12% increase in body mass using a weighted vest); and (3) unloaded (12% decrease in body mass using lower body positive pressure). Venous blood was collected before, immediately after, and 15 and 30 minutes after exercise to investigate cartilage turnover (sCOMP) and anabolism (PIIANP).

Condition or Disease	Intervention/Treatment	Phase
Healthy	Other: Control Condition Other: +12% Body Mass Other: -12% Body Mass	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

15 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

A Preliminary Study on the Effect of Loaded and Unloaded Exercise on Anabolic and Turnover Activity of Articular Cartilage in Healthy Young Adults

Actual Study Start Date :

Sep 27, 2019

Actual Primary Completion Date :

Mar 1, 2020

Actual Study Completion Date :

Mar 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Control The control condition did 30 minutes of walking exercise with their own body mass.	Other: Control Condition Control (no alteration to body mass).
Experimental: +12% Body Mass The +12% body mass condition did 30 minutes of walking exercise wearing a weighted vest with +12% of their body mass applied.	Other: +12% Body Mass Loaded walking exercise (12% increase in body mass using a weighted vest).
Experimental: -12% Body Mass The -12% body mass condition did 30 minutes of walking exercise using a lower body positive pressure treadmill with -12% of their body mass applied.	Other: -12% Body Mass Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Arm

Intervention/Treatment

Experimental: Control

The control condition did 30 minutes of walking exercise with their own body mass.

Other: Control Condition

Control (no alteration to body mass).

Experimental: +12% Body Mass

The +12% body mass condition did 30 minutes of walking exercise wearing a weighted vest with +12% of their body mass applied.

Other: +12% Body Mass

Loaded walking exercise (12% increase in body mass using a weighted vest).

Experimental: -12% Body Mass

The -12% body mass condition did 30 minutes of walking exercise using a lower body positive pressure treadmill with -12% of their body mass applied.

Other: -12% Body Mass

Unloaded walking exercise (12% decrease in body mass using lower body positive pressure).

Outcome Measures

Primary Outcome Measures

Serum cartilage oligomeric matrix protein (sCOMP) [sCOMP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.]
The systemic blood serum concentration of sCOMP was evaluated in all participants under the 3 conditions in a crossover trial.
N-propeptide of type II collagen (PIIANP) [PIIANP was measured at baseline, immediately post, and 15- and 30-minutes post exercise.]
The systemic blood serum concentration of PIIANP was evaluated in all participants under the 3 conditions in a crossover trial.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy
18-30 years old

Exclusion Criteria:

Traumatic injury to the lower extremity in the past year
Hip, knee, or ankle surgery
Radiographic evidence of joint degeneration
Cardiovascular disease
Ankylosing spondylitis
Psoriatic arthritis
Chronic reactive arthritis
Renal problems requiring peritoneal dialysis or hemodialysis
Not currently using any prescription or non-prescription medications and/or nutritional supplements

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Manitoba	Winnipeg	Manitoba	Canada	R3T 2N2

Sponsors and Collaborators

University of Manitoba

Investigators

Principal Investigator: Stephen M Cornish, PhD, University of Manitoba

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University of Manitoba

ClinicalTrials.gov Identifier:

NCT05925244

Other Study ID Numbers:

HS22322

First Posted:

Jun 29, 2023

Last Update Posted:

Jul 3, 2023

Last Verified:

Jun 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by University of Manitoba

Study Results

No Results Posted as of Jul 3, 2023