Effects of Combined Interventions to Optimize Recovery During High-intensity Exercises in Healthy Adults

Sponsor

Swiss Federal Institute of Technology (Other)

Overall Status

Completed

CT.gov ID

NCT04508738

Collaborator

(none)

Enrollment

Location

Arms

9.6

Actual Duration (Months)

1.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The objective of the study is to evaluate the effects a complex recovery intervention during the breaks of a repeated sprint test on exercise performance compared to placebo and control conditions. The enhanced recovery package (ERP) includes neck cooling with an iced gel pad, drinking a 6% CHO solution, mouth-rinsing with a 10% CHO, 6 mg･kg -1 caffeine solution, performing submaximal squats and hyperventilating a hyperoxic mixture; all applied in each 3-min break in-between the six 30-s sprints. This intervention will be compared to a placebo and a control condition.

Condition or Disease	Intervention/Treatment	Phase
Healthy	Other: ERP Other: Placebo	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

16 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Intervention Model Description:

Each participant will be tested on 4 different days with a control, a placebo and an interventional condition in random order.Each participant will be tested on 4 different days with a control, a placebo and an interventional condition in random order.

Masking:

Single (Participant)

Masking Description:

Participants will be blinded about the true nature of the placebo intervention

Primary Purpose:

Other

Official Title:

Effects of Combined Interventions to Optimize Recovery During High-intensity Exercises in Healthy Adults

Actual Study Start Date :

Sep 10, 2020

Actual Primary Completion Date :

Jun 30, 2021

Actual Study Completion Date :

Jun 30, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: ERP Intervention Combination of different methods to improve recovery.	Other: ERP The ERP intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. ERP: 1) neck cooling with an iced gel pad, 2) drinking a ∼ 6% CHO solution, 3) mouth-rinsing with a ∼10% CHO, ∼6 mg ･ kg -1 caffeine solution, 4) performing submaximal squats and 5) hyperventilating a hyperoxic mixture
No Intervention: Control Passive recovery by sitting on a chair
Placebo Comparator: Placebo A combination of methods similar to the ERP intervention but at an intensity / mixture supposed to be ineffective at improving recovery.	Other: Placebo The control intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. 1) neck "cooling" with room temperature gel pack, 2) drinking an artificially sweetened solution, 3) mouth-rinsing with artificially sweetened solution (containing no caffeine), 4) performing unloaded squat manoeuvres, 5) deep breaths with room air

Arm

Intervention/Treatment

Experimental: ERP Intervention

Combination of different methods to improve recovery.

Other: ERP

The ERP intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. ERP: 1) neck cooling with an iced gel pad, 2) drinking a ∼ 6% CHO solution, 3) mouth-rinsing with a ∼10% CHO, ∼6 mg ･ kg -1 caffeine solution, 4) performing submaximal squats and 5) hyperventilating a hyperoxic mixture

No Intervention: Control

Passive recovery by sitting on a chair

Placebo Comparator: Placebo

A combination of methods similar to the ERP intervention but at an intensity / mixture supposed to be ineffective at improving recovery.

Other: Placebo

The control intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. 1) neck "cooling" with room temperature gel pack, 2) drinking an artificially sweetened solution, 3) mouth-rinsing with artificially sweetened solution (containing no caffeine), 4) performing unloaded squat manoeuvres, 5) deep breaths with room air

Outcome Measures

Primary Outcome Measures

Change in mean power output [through study completion, an expected average of 3 weeks per participant]
Measured over the six 30s high-intensity cycling sprints in each of the three conditions. Mean power mirrors the body's ability to generate muscle power and physical energy. Any meaningful effects of the recovery interventions will eventually translate into a higher power output.
Change in fatigue index [through study completion, an expected average of 3 weeks per participant]
Fatigue index = drop in power output from the beginning to the end a 30s sprint test. The change in this index will be calculated from the 1st to the 6th sprint test in each condition.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 40 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Informed Consent as documented by signature (Appendix Informed Consent Form)
Healthy
Male
Age: 18-40 years
Body-Mass-Index (BMI): 18.5-24.9 kg･m-2
Trained individuals: max. Power output ≥ 4.0 Watts･kg-1
Non-smoking
Willingness to adhere to the study rules

Exclusion Criteria:

Known or suspected non-compliance, drug or alcohol abuse
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participants
Previous enrolment into the current study
Intake of medications affecting performance or the respiratory, cardiovascular or neuromuscular system
Acute or chronic illness affecting performance or the respiratory, cardiovascular or neuromuscular system

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	ETH Zürich, Exercise Physiology Lab	Zürich	ZH	Switzerland	8057

Sponsors and Collaborators

Swiss Federal Institute of Technology

Investigators

Principal Investigator: Christina M. Spengler, Prof., Christina M. Spengler, Prof. Study Principal Investigator Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Swiss Federal Institute of Technology

ClinicalTrials.gov Identifier:

NCT04508738

Other Study ID Numbers:

ERP_2020

First Posted:

Aug 11, 2020

Last Update Posted:

Jul 2, 2021

Last Verified:

Oct 1, 2020

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Study Results

No Results Posted as of Jul 2, 2021