Evaluation of Drainable Volume Measurements During VA-ELS
Study Details
Study Description
Brief Summary
Veno-arterial extracorporeal life support (VA-ELS) is used to support patients with acute cardiac failure. In that context, sufficient drainable venous volume is crucial for reliable and adequate support. To date, no reliable measurement method exists to monitor drainable volume adequately. Furthermore, it is still unresolved how to diagnose adequate cardiac recovery.
Previous (pre)clinical studies showed that the calculation of the dynamic filling index may provide a valuable parameter to monitor the drainable volume in patients supported by VAELS. In addition, a case report showed that measurement of the dynamic filling index could successfully be used to estimate cardiac recovery in a single patient supported by VA-ELS in the ICU.
This study will assess the dynamic filling index as a representation for drainable volume and cardiac recovery using standard recorded perfusion data in patients supported by VA-ELS
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Pump speed variation VA-ELS pump speed variations |
Device: VA-ELS pump speed variations
Small variations in the pump speed of the veno-arterial extracorporeal life support (VA-ELS) pump
|
Outcome Measures
Primary Outcome Measures
- TEE results [participants will be followed for the duration of the VA-ELS support, an expected average of 1 week]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Written informed consent of the relative(s) or legal representative(s)
-
Supported by VA-ELS at the ICU
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18 years
Exclusion Criteria:
- Pregnancy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Maastricht University Hospital | Maastricht | Netherlands | 6229 HX |
Sponsors and Collaborators
- Maastricht University Medical Center
Investigators
- Principal Investigator: Patrick W. Weerwind, Dr., Maastricht University Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Simons AP, Lancé MD, Reesink KD, van der Veen FH, Weerwind PW, Maessen JG. Quantitative assessment of cardiac load-responsiveness during extracorporeal life support: case and rationale. J Cardiothorac Surg. 2010 Apr 27;5:30. doi: 10.1186/1749-8090-5-30.
- Simons AP, Reesink KD, Lancé MD, van der Nagel T, van der Veen FH, Weerwind PW, Maessen JG. Reserve-driven flow control for extracorporeal life support: proof of principle. Perfusion. 2010 Jan;25(1):25-9. doi: 10.1177/0267659109360284. Epub 2010 Jan 29.
- Simons AP, Reesink KD, Lancé MD, van der Veen FH, de Jong DS, Weerwind PW, Maessen JG. Dynamic filling index: a novel parameter to monitor circulatory filling during minimized extracorporeal bypass. Eur J Cardiothorac Surg. 2009 Aug;36(2):330-4. doi: 10.1016/j.ejcts.2009.03.045. Epub 2009 May 2.
- NL49011.000.14