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Heat Intolerance- A Lesson From Global Genomic Response in Lymphocytes

Sponsor
Medical Corps, Israel Defense Force (Other)
Overall Status
Unknown status
CT.gov ID
NCT00918359
Collaborator
(none)
50
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Heat Intolerance (HI) is a life threatening deficiency that can lead to heat exhaustion, heat stroke (and possibly death) in a large number of military and civilian occupational groups. We have demonstrated malfunction of transcriptional pathways in the heat stressed HI phenotype and an altered gene expression profile compared to Heat Tolerant (HT) individuals. Such differences are evident even under normothermic basal/comfort conditions. Heat and exercise challenges during the heat tolerance test (HTT) further emphasize the differences between the groups, particularly during recovery at comfort temperatures. Our results indicate that it may be possible to identify markers of heat intolerance. To achieve this goal, we plan to design a cellular (lymphocyte) HTT experimental model and detect gene expression profiles using customized DNA microarrays and bioinformatic tools (the genes selected will be based on our previous DNA microarray studies). Lymphocyte samples collected from HT and HI individuals under resting/comfort conditions will be examined. Treatments and analyses are designed to reveal HI-associated gene-expression profiles (constitutive or inducible), and thereby find lymphocyte markers to identify individuals predisposed to heat injury. The identification of such subjects could prevent unnecessary loss of life. Notably, the rapidly changing climate in our era increases the number of occupation/age groups in which manifestations of HI will appear.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    50 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Following Study: Heat Intolerance- A Lesson From Global Genomic Response in Lymphocytes
    Study Start Date :
    May 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    HI

    Subjects who experienced heat exhaustion or heat stroke in their past and will be identified by heat tolerance test (HTT) as Heat Intolerance .
    HT

    Subjects who experienced heat exhaustion or heat stroke in their past and will be identified by heat tolerance test (HTT) as Heat Tolerance .

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 45 Years
      Sexes Eligible for Study:
      Male
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • Experienced heat exhaustion or heat stroke in their past

      • Participating in heat tolerance tests (HTT)

      Exclusion Criteria:

      • Unambiguous result of the HTT

      • HTT stop by the subject decision

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Heller Institute of Medical Research Ramat Gan Israel 52621

      Sponsors and Collaborators

      • Medical Corps, Israel Defense Force

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00918359
      Other Study ID Numbers:
      • 782-2008-IDF-CTIL
      First Posted:
      Jun 11, 2009
      Last Update Posted:
      Jun 29, 2011
      Last Verified:
      Jun 1, 2011
      Additional relevant MeSH terms:
      Disease Susceptibility

      Study Results

      No Results Posted as of Jun 29, 2011