METAFORE: Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II Study

Sponsor

Hospices Civils de Lyon (Other)

Overall Status

Completed

CT.gov ID

NCT00843440

Collaborator

(none)

Enrollment

Location

Arm

Duration (Months)

0.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The efficacy of anti-VEGF treatments such as Bevacizumab in cases of HHT can be considered because of the molecular mechanisms implied in angiogenesis and HHT, as well as the mechanisms of action of this type of treatment. Two articles that have recently reported spectacular improvement thanks to Bevacizumab in patients with HHT complicated with severe liver involvement and cardiac effects support us in this sense.

Up to now, the only treatment recommended in the severe hepatic forms of HHT is a liver transplant, the disadvantages of which are both multiple and well known: long waiting lists, surgical morbidity and mortality, immunosuppressive treatment for life. Furthermore, treatment with Bevacizumab is not a contraindication, should the drug be ineffective, for a subsequent liver transplant if necessary.

Condition or Disease	Intervention/Treatment	Phase
Hemorrhagic Hereditary Telangiectasia	Drug: Bevacizumab	Phase 2

Study Design

Study Type:

Interventional

Actual Enrollment :

25 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Efficacy and Safety of Bevacizumab for the Treatment Hemorrhagic Hereditary Telangiectasia (HHT) Associated With Severe Hepatic Vascular Malformations. Phase II Study.

Study Start Date :

Mar 1, 2009

Actual Primary Completion Date :

Mar 1, 2009

Actual Study Completion Date :

Mar 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Bevacizumab Study using a Gehan design, 7 patients will be included in the first phase and 18 additional patients will enter the second phase.	Drug: Bevacizumab 5 mg / kg every 14 days with a total of 6 injections.A two-phase Gehan method will be used with a first phase designed to eliminate a non effective treatment quickly and a second phase allowing assessment of efficacy. Other Names: AVASTIN

Arm

Intervention/Treatment

Experimental: Bevacizumab

Study using a Gehan design, 7 patients will be included in the first phase and 18 additional patients will enter the second phase.

Drug: Bevacizumab

5 mg / kg every 14 days with a total of 6 injections.A two-phase Gehan method will be used with a first phase designed to eliminate a non effective treatment quickly and a second phase allowing assessment of efficacy.

Other Names:

AVASTIN

Outcome Measures

Primary Outcome Measures

cardiac output measured at 3 months [3 months]

Secondary Outcome Measures

Evaluation at 6 and 12 months [12 months]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

General criteria:
Age ≥ 18 years and < 70 years
Subjects must have given their free and enlightened consent and have signed the consent form.
HHT related criteria
Patients monitored for clinically confirmed HHT disease.
Patients with severe liver involvement in relationship with the HHT disease
Patients with a high cardiac output on ultrasound.
Associated disease related criteria
Blood: neutrophil ≥ 1.0x109 / L and platelets ≥ 100x109 / L.
INR (International Normalized Ratio) ≤ 1.5 (except for patients on anticoagulants) and TCA ≤ 1.5 x upper limit of the standard laboratory
Renal function: creatinine ≤ 1.25 x upper limit of the standard laboratory. Patients who proteinuria to strip ≥ 2 + will have control of the Proteinuria of 24 hours to be ≤ 1g / 24 hours

Exclusion Criteria:

• General criteria
Women who are pregnant or liable to become pregnant in the course of the trial.
Patients who have reached their majority but who are protected by the terms of the law (French public health code).
Refusal to give enlightened consent.
Patients who are not affiliated to a health insurance regime

• Criteria for the medical history

Patients in whom the diagnosis of HHT disease has not been confirmed.
The presence of atrial fibrillation on the electrocardiogram at the inclusion.
The presence of cerebral arteriovenous malformations on the angioMRI done in the year prior to inclusion.
Existence of diverticulitis of the colon or sigmoid
Thrombosis within 6 months before inclusion
Infectious disease treated by antibiotics and unresolved at inclusion.
Patients with blood pressure that is not being controlled at the time of inclusion (systolic blood pressure> 150 mmHg and / or diastolic> 100 mmHg) with or without treatment. Patients who have high blood pressure can be included when the blood pressure numbers have been standardized by appropriate medical treatment.

• Surgical criteria

Major surgery (including open biopsy) or severe trauma within 28 days preceding the start of treatment.

• Medical treatments

Current or recent use of non steroidal anti-inflammatory drugs or antiplatelet therapy 10 days before the first administration of Bevacizumab.
Use of oral or parenteral anticoagulants or thrombolytic agents within 28 days preceding inclusion (anticoagulants given prophylactically are permitted).
Participation in another clinical trial within 28 days preceding inclusion.
Vaccination with live vaccines or against yellow fever during the treatment period.
Administration of phenytoin (Di-hydan ® DILANTIN ®) during the treatment period.

• Allergy

Hypersensitivity to the active substance or any of its excipients.
Hypersensitivity to products made from Chinese hamster ovary (CHO) cells or to any other human or humanized recombinant antibodies.