A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
Sponsor
Daiichi Sankyo, Inc. (Industry)
Overall Status
Recruiting
CT.gov ID
NCT04622319
Collaborator
AstraZeneca (Industry), NSABP Foundation Inc (Other), German Breast Group (Other), Spanish Breast Cancer Research Group (SOLTI) (Other)
1,600
501
2
80.9
3.2
0
Study Details
Study Description
Brief Summary
Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine (T-DM1) in high-risk patients with residual invasive breast cancer following neoadjuvant therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Detailed Description
This study will examine trastuzumab deruxtecan (T-DXd) versus trastuzumab emtansine (T-DM1) in patients with HER2-positive primary BC who have residual invasive disease in breast or axillary lymph nodes with higher risk of recurrence, which includes patients who were inoperable at disease presentation or had pathological node-positive status after neoadjuvant therapy.
The primary objective is to compare invasive disease-free survival (IDFS) between T-DXd and T-DM1 treatment arms in this population. The key secondary objective of the study is to evaluate disease-free survival (DFS).
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
1600 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in Participants With High-Risk HER2-Positive Primary Breast Cancer Who Have Residual Invasive Disease in Breast or Axillary Lymph Nodes Following Neoadjuvant Therapy (DESTINY-Breast05)
Actual Study Start Date
:
Dec 4, 2020
Anticipated Primary Completion Date
:
Dec 31, 2025
Anticipated Study Completion Date
:
Sep 1, 2027
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Trastuzumab deruxtecan (T-DXd) Participants who will be randomized to receive trastuzumab deruxtecan (T-DXd) at a starting dose of 5.4 mg/kg. |
Drug: DS-8201a
Administered initially as an intravenous (IV) infusion at a dose of 5.4 mg/kg on Day 1 of each 21-day cycle
Other Names:
|
| Active Comparator: Trastuzumab ematansine (T-DM1) Participants who will be randomized to receive trastuzumab ematansine (T-DM1) at a starting dose of 3.6 mg/kg. |
Drug: T-DM1
Administered initially as an intravenous (IV) infusion at a dose of 3.6 mg/kg on Day 1 of each 21-day cycle
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Invasive Disease-free Survival (IDFS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Randomization to date of invasive local, axillary or distant recurrence, invasive contralateral breast cancer or death from any cause (whichever occurs first), up to approximately 81 months postdose]
Secondary Outcome Measures
- Disease-free Survival (DFS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Randomization to date of the first occurrence of an IDFS event including second primary non-breast cancer event or contralateral or ipsilateral ductal carcinoma in situ (whichever occurs first), up to approximately 81 months postdose]
- Overall Survival (OS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Randomization to date of death from any cause, up to approximately 81 months postdose]
- Distant Recurrence-free Interval (DRFI) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Randomization to date of distant recurrence, up to approximately 81 months postdose]
- Brain Metastases-free Interval (BMFI) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Randomization to date of brain metastasis, up to approximately 81 months postdose]
- Percentage of Treatment-emergent Adverse Events in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [Baseline up to approximately 81 months postdose]
- Serum Concentrations of Trastuzumab Deruxtecan (T-DXd), total anti-HER2 antibody, and Active Metabolite MAAA-1181a [Pre-dose on Day 1 of Cycles 1, 4 and 10 and within 15 minutes post-dose on Day 1 of Cycles 1 and 4 (each cycle is 21 days)]
- Percentage of Participants Positive for Treatment-emergent Anti-drug Antibodies (ADAs) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) [Baseline up to approximately 81 months postdose]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Key Inclusion Criteria:
-
Adults ≥18 years old (local regulatory requirements will apply if the legal age of consent for study participation is >18 years old)
-
Pathologically documented HER2-positive breast cancer (BC):
-
HER2-positive expression defined as an immunohistochemistry (IHC) score of 3+ and/or positive by in situ hybridization (ISH) confirmed prior to study randomization
-
Histologically confirmed invasive breast carcinoma
-
Clinical stage at disease presentation: T1-4, N0-3, M0; patients presenting with T1N0 tumors are not eligible
-
Pathologic evidence of residual invasive carcinoma in the breast and/or axillary lymph nodes following completion of neoadjuvant therapy meeting one of the following high-risk criteria:
-
Inoperable breast cancer at presentation (prior to neoadjuvant therapy), defined as clinical stages T4, N0-3, M0 or T1-3, N2-3, M0
-
Operable at presentation, defined as clinical stages T1-3,N0-1,M0, with axillary node positive disease (ypN1-3) following neoadjuvant therapy
-
Completion of neoadjuvant systemic chemotherapy, including taxane and HER2-directed treatment prior to surgery
-
Systemic therapy must consist of at least 6 cycles of chemotherapy with a total duration of at least 16 weeks, including at least 9 weeks of trastuzumab (± pertuzumab) and at least 9 weeks of taxane based chemotherapy. Patients may have received an anthracycline as part of neoadjuvant therapy in addition to taxane chemotherapy.
-
Adequate excision as confirmed per medical records: surgical removal of all clinically evident disease in the breast and lymph nodes.
-
An interval of no more than 12 weeks between the date of last surgery and the date of randomization.
-
Known hormone receptor (HR) status, per local laboratory assessment, as defined by ASCO-CAP guidelines (≥1%): HR positive status defined by either positive estrogen receptor (ER) and/or positive progesterone receptor (PR) status. HR-negative status defined by both known negative ER and known negative PR.
-
Left ventricular ejection fraction (LVEF) ≥50% within 28 days prior to randomization.
-
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at Screening.
-
Has adequate organ function within 14 days before randomization.
Key Exclusion Criteria:
-
Stage IV (metastatic) BC
-
History of any prior (ipsi- or contralateral) breast cancer except lobular carcinoma in situ (LCIS)
-
Evidence of clinically evident gross residual or recurrent disease following neoadjuvant therapy and surgery
-
Prior treatment with T-DXd, T-DM1 or other anti-HER2 antibody-drug conjugate (ADC)
-
History of exposure to the following cumulative doses of anthracyclines:
-
Doxorubicin > 240 mg/m^2
-
Epirubicin or Liposomal Doxorubicin-Hydrochloride > 480 mg/m^2
-
For other anthracyclines, exposure equivalent to doxorubicin > 240 mg/m^2
-
History of other malignancy within the last 5 years except for appropriately treated CIS of the cervix, nonmelanoma skin carcinoma, Stage I melanoma skin carcinoma, Stage I uterine cancer, or other appropriately treated non-breast malignancies
-
History of (noninfectious) interstitial lung disease (ILD)/pneumonitis that required steroids and/or has ILD/pneumonitis noted on computed tomography (CT) scan of the chest at Screening (asymptomatic interstitial changes confined to recent radiation therapy fields are not excluded)
-
Known pulmonary compromise resulting from intercurrent pulmonary illnesses including, but not limited to, any underlying pulmonary disorder (eg, pulmonary emboli within three months prior to randomization, severe asthma, severe chronic obstructive pulmonary disease [COPD], restrictive lung disease).
-
Any autoimmune, connective tissue or inflammatory disorders with pulmonary involvement (eg, Rheumatoid arthritis, Sjogren's, sarcoidosis, etc.), or prior lobectomy or pneumonectomy
-
Medical history of myocardial infarction (MI) within 6 months before randomization, symptomatic congestive heart failure (CHF) (New York Heart Association Class II to IV), troponin levels consistent with MI as defined according to the manufacturer 28 days prior to randomization
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Oncology Institute of Hope & Innovation | Anaheim | California | United States | 92801 |
| 2 | Kaiser Permanente | Anaheim | California | United States | 92806 |
| 3 | Kaiser Permanente | Baldwin Park | California | United States | 91706 |
| 4 | Kaiser Permanente | Bellflower | California | United States | 90706 |
| 5 | Kaiser Permanente | Fontana | California | United States | 92335 |
| 6 | Orange Coast Blood and Cancer Care | Fountain Valley | California | United States | 92708 |
| 7 | Orange Coast Memorial Med Center | Fountain Valley | California | United States | 92708 |
| 8 | Kaiser Permanente | Harbor City | California | United States | 90710 |
| 9 | Kaiser Permanente | Irvine | California | United States | 92618 |
| 10 | Long Beach Memorial TCI | Long Beach | California | United States | 90806 |
| 11 | Kaiser Permanente | Los Angeles | California | United States | 90027 |
| 12 | Kaiser Permanente | Ontario | California | United States | 90710 |
| 13 | Kaiser Permanente | Panorama City | California | United States | 91402 |
| 14 | Kaiser Permanente | Riverside | California | United States | 92505 |
| 15 | Kaiser Permanente | San Diego | California | United States | 92120 |
| 16 | Kaiser Permanente | San Marcos | California | United States | 92078 |
| 17 | Kaiser Permanente | West Los Angeles | California | United States | 90034 |
| 18 | Kaiser Permanente | Woodland Hills | California | United States | 91367 |
| 19 | SCRI FCS North- Altamonte | Altamonte Springs | Florida | United States | 32701 |
| 20 | SCRI FCS South- Bonita | Bonita Springs | Florida | United States | 34135 |
| 21 | SCRI FCS North- Brandon Cancer Center | Brandon | Florida | United States | 33511 |
| 22 | SCRI FCS South- North Fort Myers | Cape Coral | Florida | United States | 33909 |
| 23 | SCRI FCS North- Mease/Clearwater | Clearwater | Florida | United States | 33761 |
| 24 | SCRI FCS South | Fort Myers | Florida | United States | 33901 |
| 25 | SCRI FCS South- Colonial | Fort Myers | Florida | United States | 33905 |
| 26 | SCRI FCS South- Gladiolus | Fort Myers | Florida | United States | 33908 |
| 27 | SCRI FCS North- Gainesville Cancer Center | Gainesville | Florida | United States | 32605 |
| 28 | Baptist MD Anderson Cancer Center | Jacksonville | Florida | United States | 32207 |
| 29 | SCRI FCS North- Villages East | Lady Lake | Florida | United States | 32159 |
| 30 | SCRI FCS South- Lakewood Ranch | Lakewood Ranch | Florida | United States | 34211 |
| 31 | SCRI FCS North- Largo/Highland | Largo | Florida | United States | 33770 |
| 32 | SCRI FCS North- Lecanto | Lecanto | Florida | United States | 34461 |
| 33 | SCRI FCS South- Naples West | Naples | Florida | United States | 34102 |
| 34 | SCRI FCS South- Naples/Goodlette | Naples | Florida | United States | 34119 |
| 35 | SCRI FCS North- New Port Richey | New Port Richey | Florida | United States | 34655 |
| 36 | SCRI FCS North- Ocala | Ocala | Florida | United States | 34474 |
| 37 | Orlando Health | Ocoee | Florida | United States | 34761 |
| 38 | SCRI FCS North- Orange City | Orange City | Florida | United States | 32763 |
| 39 | Orlando Health | Orlando | Florida | United States | 32806 |
| 40 | SCRI FCS North- Orlando Downtown | Orlando | Florida | United States | 32806 |
| 41 | SCRI FCS South- Port Charlotte | Port Charlotte | Florida | United States | 33980 |
| 42 | SCRI FCS North- St. Anthony's/St. Petersburg | Saint Petersburg | Florida | United States | 33705 |
| 43 | SCRI FCS North | Saint Petersburg | Florida | United States | 33705 |
| 44 | SCRI FCS South- Sarasota-Cattleman | Sarasota | Florida | United States | 34232 |
| 45 | SCRI FCS South-Sarasota-Downtown | Sarasota | Florida | United States | 34236 |
| 46 | SCRI FCS North- Spring Hill | Spring Hill | Florida | United States | 34608 |
| 47 | SCRI FCS North- Tampa Cancer Center | Tampa | Florida | United States | 33607 |
| 48 | SCRI FCS North- Tavares | Tavares | Florida | United States | 32778 |
| 49 | SCRI FCS South- Venice Healthpark | Venice | Florida | United States | 34292 |
| 50 | Cleveland Clinic-Weston | Weston | Florida | United States | 33326 |
| 51 | SCRI FCS North- Winter Park | Winter Park | Florida | United States | 32792 |
| 52 | Elmhurst Memorial Hospital- Nancy W. Knowles Cancer Center | Elmhurst | Illinois | United States | 60126 |
| 53 | Edward Cancer Center | Naperville | Illinois | United States | 60540 |
| 54 | Illinois CancerCare | Peoria | Illinois | United States | 61615 |
| 55 | Edward Cancer Center Plainfield | Plainfield | Illinois | United States | 60585 |
| 56 | University of Kentucky, Markey Cancer Center, Clinical Research Organization | Lexington | Kentucky | United States | 40536 |
| 57 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 58 | LSU Health Baton Rouge North Clinic | Baton Rouge | Louisiana | United States | 70805 |
| 59 | Our Lady of the Lake Physician Group-Medical Oncology | Baton Rouge | Louisiana | United States | 70808 |
| 60 | Our Lady of the Lake Physicians Group-Medical Oncology-Woman's Pavilion | Baton Rouge | Louisiana | United States | 70808 |
| 61 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 62 | Ochsner Hematology Oncology North Shore - Covington (West Region) | Covington | Louisiana | United States | 70433 |
| 63 | Ochsner Clinic Foundation | New Orleans | Louisiana | United States | 70121 |
| 64 | Mercy Medical Center | Baltimore | Maryland | United States | 21202 |
| 65 | MedStar Franklin Square Medical Center-Harry and Jeanette Weinberg Cancer Institute | Baltimore | Maryland | United States | 21237 |
| 66 | MedStar Franklin Square Cancer Center at Loch Raven Campus | Baltimore | Maryland | United States | 21239 |
| 67 | Richard A. Henson Cancer Institute Ocean Pines | Berlin | Maryland | United States | 21811 |
| 68 | Frederick Health-James M Stockman Cancer Center | Frederick | Maryland | United States | 21702 |
| 69 | Peninsula Regional Medical Center | Salisbury | Maryland | United States | 21801 |
| 70 | Maryland Oncology Hematology | Silver Spring | Maryland | United States | 20904 |
| 71 | Holy Cross Hospital | Silver Spring | Maryland | United States | 20910 |
| 72 | Montefiore Medical Center | Bronx | New York | United States | 10461 |
| 73 | Waverly Hematology Oncology | Cary | North Carolina | United States | 27518 |
| 74 | Levine Cancer Inst Pineville | Charlotte | North Carolina | United States | 28210 |
| 75 | Levince Cancer Institute | Charlotte | North Carolina | United States | 28277 |
| 76 | Carolinas Medical Center Northeast | Concord | North Carolina | United States | 28025 |
| 77 | UNC REX Cancer Center | Raleigh | North Carolina | United States | 27607 |
| 78 | UNC REX Cancer Center of Wakefield | Raleigh | North Carolina | United States | 27614 |
| 79 | UNC Cancer Care at Nash | Rocky Mount | North Carolina | United States | 27804 |
| 80 | Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | United States | 27157 |
| 81 | Cleveland Clinic - Hillcrest | Cleveland | Ohio | United States | 44195 |
| 82 | Cleveland Clinic-Fairview | Cleveland | Ohio | United States | 44195 |
| 83 | Cleveland Clinic | Cleveland | Ohio | United States | 44195 |
| 84 | Cleveland Clinic South Pointe | Warrensville Heights | Ohio | United States | 44195 |
| 85 | Kaiser Permanente Northwest--Oncology | Portland | Oregon | United States | 97015 |
| 86 | UPMC Upper St. Clair | Bethel Park | Pennsylvania | United States | 15102 |
| 87 | UPMC Passavant Cranberry/North | Cranberry Township | Pennsylvania | United States | 16066 |
| 88 | UPMC Erie | Erie | Pennsylvania | United States | 16505 |
| 89 | AHN Cancer Inst at St Vincent | Erie | Pennsylvania | United States | 16544 |
| 90 | UPMC Arnold Palmer-Mt View | Greensburg | Pennsylvania | United States | 15601 |
| 91 | UPMC Pinnacle-Ortenzio Cancer Center | Harrisburg | Pennsylvania | United States | 17050 |
| 92 | UMPC Pinnacle Pharmacy | Harrisburg | Pennsylvania | United States | 17109 |
| 93 | AHN Cancer Insititute at Jefferson | Jefferson Hills | Pennsylvania | United States | 15025 |
| 94 | AHN Cancer Institute at Forbes | Monroeville | Pennsylvania | United States | 15146 |
| 95 | UPMC Monroeville | Monroeville | Pennsylvania | United States | 15146 |
| 96 | UPMC Arnold Palmer-Mt Pleasant | Mount Pleasant | Pennsylvania | United States | 15666 |
| 97 | UPMC Arnold Palmer-Norwin | N. Huntingdon | Pennsylvania | United States | 15642 |
| 98 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 99 | Magee | Pittsburgh | Pennsylvania | United States | 15213 |
| 100 | UPMC St. Margaret | Pittsburgh | Pennsylvania | United States | 15215 |
| 101 | AHN Cancer Inst at West Penn | Pittsburgh | Pennsylvania | United States | 15224 |
| 102 | UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | United States | 15232 |
| 103 | UPMC Passavant HOA | Pittsburgh | Pennsylvania | United States | 15237 |
| 104 | UPMC Passavant OHA | Pittsburgh | Pennsylvania | United States | 15237 |
| 105 | UPMC Uniontown | Uniontown | Pennsylvania | United States | 15401 |
| 106 | UPMC Washington | Washington | Pennsylvania | United States | 15301 |
| 107 | Reading Hospital, McGlinn Cancer Institute | West Reading | Pennsylvania | United States | 19611 |
| 108 | AHN Cancer Institute at Wexford | Wexford | Pennsylvania | United States | 15090 |
| 109 | UPMC Pinnacle-Memorial Cancer Center | York | Pennsylvania | United States | 17408 |
| 110 | Women & Infants Hospital of RI | Providence | Rhode Island | United States | 02905 |
| 111 | SCRI TO Nashville- Franklin Tennessee Oncology, PLLC | Franklin | Tennessee | United States | 37067 |
| 112 | SCRI TO Nashville- Gallatin Tennessee Oncology, PLLC | Gallatin | Tennessee | United States | 37066 |
| 113 | SCRI TO Nashville- Hendersonville Tennessee Oncology, PLLC | Hendersonville | Tennessee | United States | 37075 |
| 114 | SCRI TO Nashville- Summit Tennessee Oncology, PLLC | Hermitage | Tennessee | United States | 37076 |
| 115 | Regional Cancer Center at Indian Path Community Hospital | Kingsport | Tennessee | United States | 37660 |
| 116 | SCRI TO Nashville- Lebanon Tennessee Oncology, PLLC | Lebanon | Tennessee | United States | 37090 |
| 117 | SCRI TO Nashville- St. Thomas Midtown Tennessee Oncology, PLLC | Nashville | Tennessee | United States | 37203 |
| 118 | Tennessee Oncology Nashville / Sarah Cannon | Nashville | Tennessee | United States | 37203 |
| 119 | SCRI TO Nashville- St. Thomas West Tennessee Oncology, PLLC | Nashville | Tennessee | United States | 37205 |
| 120 | SCRI TO Nashville- Skyline Tennessee Oncology, PLLC | Nashville | Tennessee | United States | 37207 |
| 121 | SCRI TO Nashville- Southern Hills Tennessee Oncology, PLLC | Nashville | Tennessee | United States | 37211 |
| 122 | SCRI TO Nashville- Smyrna Tennessee Oncology, PLLC | Smyrna | Tennessee | United States | 37167 |
| 123 | Houston Methodist Baytown | Baytown | Texas | United States | 77521 |
| 124 | Houston Methodist | Houston | Texas | United States | 77030 |
| 125 | Houston Methodist Willowbrook | Houston | Texas | United States | 77070 |
| 126 | Houston Methodist West | Houston | Texas | United States | 77094 |
| 127 | Houston Methodist Clear Lake | Nassau Bay | Texas | United States | 77058 |
| 128 | Houston Methodist Sugarland | Sugar Land | Texas | United States | 77479 |
| 129 | Houston Methodist Woodlands | The Woodlands | Texas | United States | 77385 |
| 130 | Wellmont Medical Associates Oncology & Hematology | Bristol | Virginia | United States | 24201 |
| 131 | University of Virginia | Charlottesville | Virginia | United States | 22908 |
| 132 | Centra Lynchburg Hematology Oncology | Lynchburg | Virginia | United States | 24501 |
| 133 | Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 134 | MultiCare Institute for Research & Innovation | Spokane | Washington | United States | 99204 |
| 135 | MultiCare Institute for Research & Innovation | Spokane | Washington | United States | 99216 |
| 136 | MultiCare Institute for Research & Innovation | Spokane | Washington | United States | 99218 |
| 137 | West Virginia University | Morgantown | West Virginia | United States | 26506 |
| 138 | Centro Oncologico Riojano Integral | Capital | La Rioja | Argentina | 5300 |
| 139 | Sanatorio Británico de Rosario | Rosario | Santa Fe | Argentina | 2000 |
| 140 | Instituto de Oncología de Rosario | Rosario | Santa Fe | Argentina | S2000KZE, 2457 |
| 141 | COIBA | Buenos Aires | Argentina | B1884BBF | |
| 142 | Hospital Aleman | Buenos Aires | Argentina | C1118 AAT | |
| 143 | Instituto Alexander Fleming | Caba | Argentina | 1426 | |
| 144 | CER San Juan | San Juan | Argentina | 5400 | |
| 145 | Royal Adelaide Hospital | Adelaide | Australia | 5000 | |
| 146 | Chris O Brien Lifehouse | Camperdown | Australia | 2050 | |
| 147 | Monash Health | Clayton | Australia | 3168 | |
| 148 | Austin Hospital- Olivia Newto-John Cancer and Wellness Centre | Heidelberg | Australia | 3804 | |
| 149 | Peter MacCallum Cancer Centre | Melbourne | Australia | 3000 | |
| 150 | Breast Cancer Research Centre - WA | Nedlands | Australia | 6009 | |
| 151 | Genesis Care Northern Cancer | Saint Leonards | Australia | 2065 | |
| 152 | St John of God Hospital - Bendat Family Comprehensive Cancer Centre (BFCCC) | Subiaco | Australia | 2050 | |
| 153 | Southern Medical Day Care Centre | Wollongong | Australia | 2500 | |
| 154 | Antwerp University Hospital | Edegem | Antwerpen | Belgium | 2650 |
| 155 | UZ Gent | Gent | O. Vl. | Belgium | 9000 |
| 156 | Algemeen Ziekenhuis AZ Klina - Borstkliniek | Brasschaat | Belgium | 2930 | |
| 157 | Institut Jules Bordet Brussels Belgium | Brussels | Belgium | 1000 | |
| 158 | Cliniques Universitaires Saint-Luc | Brussels | Belgium | 1200 | |
| 159 | UZ Leuven - Campus Gasthuisberg | Leuven | Belgium | 3000 | |
| 160 | CHU Liege | Liège | Belgium | 4000 | |
| 161 | GZA Hospitals Campus Sint- Augustinus | Wilrijk | Belgium | 2610 | |
| 162 | Hospital Sirio-Libanes HSL - Centro de Oncologia - Brasilia | Brasília | Federal District | Brazil | 70200-730 |
| 163 | Hospital Erasto Gaertner | Curitiba | Parana | Brazil | 81520-060 |
| 164 | Fundação Universidade de Caxias do Sul Instituto de Pesquisas em Saúde IPS-UCS | Caxias Do Sul | Rio Grande Do Sul | Brazil | 95070-560 |
| 165 | Hospital Sao Lucas PUCRS | Porto Alegre | RS | Brazil | 90610-000 |
| 166 | Fundacao Pio XII-Hospital de Cancer de Barretos | Barretos | SP | Brazil | 14784-400 |
| 167 | CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia | Santo André | SP | Brazil | 09060-650 |
| 168 | Hospital de Base de Sao Jose do Rio Preto | São José Do Rio Preto | SP | Brazil | 15092415 |
| 169 | INCA - Instituto Nacional do Cancer / Hospital do Cancer HCIII | Rio De Janeiro | Brazil | 20560-120 | |
| 170 | Instituto do Cancer do Estado de Sao Paulo (ICESP) | São Paulo | Brazil | 01246-000 | |
| 171 | Tom Baker Cancer Centre | Calgary | Alberta | Canada | T2N4N2 |
| 172 | The Ottawa Hospital Cancer Centre | Ottawa | Ontario | Canada | K1H 8L6 |
| 173 | CIUSSSS de l'Est-de-l'Ile-de-Montréal - Installation Hôpital Maisonneuve-Rosemont | Montréal | Quebec | Canada | H1T 2M4 |
| 174 | CHUM | Montréal | Quebec | Canada | H2X3E4 |
| 175 | Jewish General Hospital Segal Cancer Centre | Montréal | Quebec | Canada | H3T1E2 |
| 176 | McGill University Health Centre - Cedars Cancer Centre | Montréal | Quebec | Canada | H4A 3J1 |
| 177 | CHU de Quebec - Hopital du Saint-Sacrement | Québec | Quebec | Canada | G1S 4L8 |
| 178 | Hospital Clinico Universidad de Chile | Santiago | RM | Chile | 8380456 |
| 179 | Fundacion Arturo Lopez Perez | Santiago | Chile | 7500921 | |
| 180 | SIM CRC | Temuco | Chile | 4780000 | |
| 181 | Peking University Cancer Hospital | Beijing | China | 100142 | |
| 182 | Peking University Third Hospital | Beijing | China | 100191 | |
| 183 | Jilin University JLU - First Affiliated Hospital | Changchun | China | 19512 | |
| 184 | Sichuan University - West China Hospital | Chengdu | China | 610041 | |
| 185 | Chongqing Medical University - The First Affiliated Hospital | Chongqing | China | 400016 | |
| 186 | Union Hospital of Fujian Medical University | Fuzhou | China | 35001 | |
| 187 | Sun Yat-sen Memorial Hospital | Guangzhou | China | 510030 | |
| 188 | Guangdong Academy of Medical Science | Guangzhou | China | 510080 | |
| 189 | Zhejiang Cancer Hospital | Hangzhou | China | 310002 | |
| 190 | Second Affiliated Hospital of Zhejiang University | Hangzhou | China | 310009 | |
| 191 | Harbin Medical University Cancer Hospital | Harbin | China | 150060 | |
| 192 | Shandong Cancer Hospital | Jinan | China | 250117 | |
| 193 | Nanchang University - The First Affiliated Hospital | Nanchang | China | 330006 | |
| 194 | Nanjing Medical University NMU - Jiangsu Province Hospital | Nanjing | China | 210029 | |
| 195 | Fudan University Cancer Hospital | Shanghai | China | 200032 | |
| 196 | Liaoning Cancer Hospital Institute | Shenyang | China | 110042 | |
| 197 | The 4th Hospital of Heibei Medical University | Shijiazhuang | China | 50011 | |
| 198 | The First Affiliated Hospital of Xiamen University | Xiamen | China | 361003 | |
| 199 | University Hospital Brno | Brno | Czechia | 62500 | |
| 200 | Fakultni nemocnice Kralovske Vinohrady | Prague | Czechia | 10034 | |
| 201 | Aalborg University Hospital | Aalborg | Denmark | 9000 | |
| 202 | Aarhus University Hospital | Aarhus | Denmark | 8210 | |
| 203 | Rigshospitalet | Copenhagen | Denmark | 2100 | |
| 204 | Odense University Hospital | Odense | Denmark | 5000 | |
| 205 | Soenderborg sygehus | Syddanmark | Denmark | 6400 | |
| 206 | Clinique Tivoli Ducos - Centre dOncologie et de Radiotherapie a Bordeaux | Bordeaux | Gironde | France | 33000 |
| 207 | Institut Claudius Regaud | Toulouse | Haute Garonne | France | 31059 |
| 208 | Institut De Cancerologie De La Loire | Saint-Priest-en-Jarez | Loire | France | 42270 |
| 209 | CHR Metz-Thionville | Metz cedex 03 | Lorraine | France | 57085 |
| 210 | Institut Bergonie | Bordeaux | France | 33000 | |
| 211 | Centre Georges François Leclerc | Dijon | France | 21000 | |
| 212 | CHD Vendee | La Roche-sur-Yon | France | 85925 cedex 9 | |
| 213 | Centre Hosp Univ de Grenoble CHUG | La Tronche | France | 38700 | |
| 214 | Centre Oscar Lambret | Lille | France | 59000 | |
| 215 | Centre Leon Berard | Lyon | France | 69008 | |
| 216 | Institut Paoli-Calmettes | Marseille | France | 13009 | |
| 217 | Centre de Cancérologie du Grand Montpellier | Montpellier | France | 34070 | |
| 218 | The Sel of Centre dOncologie de Gentilly | Nancy | France | 54000 | |
| 219 | Centre Antoine Lacassagne | Nice | France | 6189 | |
| 220 | Hospital St Louis | Paris | France | 75010 | |
| 221 | Hopital Georges Pompidou | Paris | France | 75015 | |
| 222 | IUC AP-HP. Sorbonne Université, Hôpital Tenon | Paris | France | 75020 | |
| 223 | CHU de Poitiers | Poitiers | France | 86021 | |
| 224 | Centre Eugene Marquis | Rennes | France | 35042 | |
| 225 | Institut de cancerologie de l'ouest | Saint-Herblain | France | 44360 | |
| 226 | Strasbourg Europe Cancer Institute | Strasbourg | France | 67033 | |
| 227 | Gemeinschaftspraxis Dres. Halder / Bangerter | Augsburg | Germany | 86150 | |
| 228 | Cahrité Campus Mitte | Berlin | Germany | 10117 | |
| 229 | Praxis Dr. med. J. Schilling | Berlin | Germany | 10317 | |
| 230 | MediOnko-Institut GbR, Praxisklinik Krebsheilkunde | Berlin | Germany | 10367 | |
| 231 | DRK Kliniken Berlin Köpenick | Berlin | Germany | 12559 | |
| 232 | Helios Klinikum Berlin-Buch | Berlin | Germany | 13125 | |
| 233 | Onkologische Schwerpunktpraxis | Berlin | Germany | 13349 | |
| 234 | Onkologische Schwerpunktpraxis | Bielefeld | Germany | 13349 | |
| 235 | Studien GbR Braunschweig | Braunschweig | Germany | 38108 | |
| 236 | Klinikum Bremen Mitte | Bremen | Germany | 28205 | |
| 237 | Hämato-Onkologische Praxis im Medicum | Bremen | Germany | 28209 | |
| 238 | Frauenklinik DIAKO Bremen | Bremen | Germany | 28239 | |
| 239 | Klinikverbund Südwest Kliniken Böblingen Frauenklinik Böblingen | Böblingen | Germany | 71065 | |
| 240 | Klinikum Chemnitz gGmbH | Chemnitz | Germany | 09116 | |
| 241 | DONAUISAR Klinikum | Deggendorf | Germany | 94469 | |
| 242 | Klinikum Dortmund gGmbH | Dortmund | Germany | 44137 | |
| 243 | St.-Johannes-Hospital Dortmund, Dept. of Obstetrics/Gynecology | Dortmund | Germany | 44137 | |
| 244 | Onkologische Schwerpunktpraxis | Dresden | Germany | 01067 | |
| 245 | University Hospital Dresden | Dresden | Germany | 01069 | |
| 246 | Onkozentrum Dresden | Dresden | Germany | 01127 | |
| 247 | Universitätsklinikum Düsseldorf, Klinik für Frauenheilkunde & Geburtshilfe | Düsseldorf | Germany | 40225 | |
| 248 | Frauenklinik der Universität Erlangen | Erlangen | Germany | 91054 | |
| 249 | Kliniken Essen-Mitte, Klinik für Senologie/ Interdisziplinäres Brustzentrum | Essen | Germany | 45136 | |
| 250 | Universitätsklinikum Essen, Frauenklinik | Essen | Germany | 45147 | |
| 251 | Klinikum Esslingen GmbH | Esslingen | Germany | 73730 | |
| 252 | AGAPLESION Markus Krankenhaus | Frankfurt am main | Germany | 60431 | |
| 253 | Frankfurt University Department of Gynecology and Obstetrics | Frankfurt | Germany | 60323 | |
| 254 | Centrum for Haematology and Oncology | Frankurt am Main | Germany | 60389 | |
| 255 | Universitätsklinik Freiburg, Klinik für Frauenheilkunde | Freiburg | Germany | 79106 | |
| 256 | Gynäkologisch-Onkologische SP-Praxis | Furstenwalde | Germany | 30177 | |
| 257 | Evangelische Kliniken Gelsenkirchen | Gelsenkirchen | Germany | 45879 | |
| 258 | MVZ II der Niels-Stensen-Kliniken | Georgsmarienhütte | Germany | 49074 | |
| 259 | SRH Waldklinikum Gera, Brustzentrum Ostthüringen | Gera | Germany | 07548 | |
| 260 | MVZ Onkologische Kooperation Harz | Goslar | Germany | 38642 | |
| 261 | Krankenhaus St. Elisabeth und St. Barbara Halle/Saale | Halle/saale | Germany | 06110 | |
| 262 | University Medical Center | Hamburg | Germany | 20251 | |
| 263 | Mammazentrum HH am Krankenhaus Jerusalem | Hamburg | Germany | 20357 | |
| 264 | Albertinen Krankenhaus | Hamburg | Germany | 22457 | |
| 265 | Gynäkologisch-Ontologische Praxis Hannover | Hannover | Germany | 30177 | |
| 266 | DIAKOVERE Henriettenstift Frauenklinik | Hannover | Germany | 30559 | |
| 267 | Gemeinschaftspraxis Frauenärzte am Bahnhofsplatz | Hildesheim | Germany | 31134 | |
| 268 | Department of Gyencology and Obstetrics, Saarland University Hospital | Homburg | Germany | 66424 | |
| 269 | ViDia Christliche Kliniken Karlsruhe | Karlsruhe | Germany | 76199 | |
| 270 | Elisabethkrankenhaus Kassel, Brustzentrum | Kassel | Germany | 34117 | |
| 271 | Klinikum Kassel | Kassel | Germany | 34125 | |
| 272 | University Hospital Schleswig-Holstein | Kiel | Germany | 24105 | |
| 273 | Institut für Versorgungsforschung in der Onkologie | Koblenz | Germany | 56068 | |
| 274 | Unifrauenklinik Köln - Studienzentrum Gynäkologie | Köln | Germany | 50931 | |
| 275 | St. Elisabeth Hospital | Köln | Germany | 50935 | |
| 276 | Kliniken der Stadt Köln / Brustzentrum Holweide | Köln | Germany | 51067 | |
| 277 | St. Elisabeth Krankenhaus | Leipzig | Germany | 50935 | |
| 278 | St. Vincenz KH Limburg | Limburg | Germany | 65549 | |
| 279 | UKSH Campus Lübeck | Luebeck | Germany | 23562 | |
| 280 | Universitäts-Frauenklinik | Magdeburg | Germany | 69120 | |
| 281 | Department of Obstetrics and Gynecology | Mainz | Germany | 55131 | |
| 282 | Medzinische Fakultät Mannheim, Universität Heidelberg | Mannheim | Germany | 68167 | |
| 283 | Klinikum Memmingen | Memmingen | Germany | 87700 | |
| 284 | Johannes Wesling Klinikum Minden, Hämatologie-Onkologie/Brustzentrum | Minden | Germany | 32429 | |
| 285 | Rotkreuzklinikum München, Frauenklinik | Muenchen | Germany | 80637 | |
| 286 | Gynaekologie Arabella | Munich | Germany | 81925 | |
| 287 | Brustzentrum Niederrhein | Mönchengladbach | Germany | 41061 | |
| 288 | Medizinisches Versorgungszentrum für Hämatologie und Onkologie München MVZ GmbH | München | Germany | 80639 | |
| 289 | LMU Klinikum/ Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe | München | Germany | 81377 | |
| 290 | Dept. OB/GYN Johanna Etienne Krankenhaus | Neuss | Germany | 41462 | |
| 291 | Ortenau Klinikum Offenburg-Kehl | Offenburg | Germany | 77694 | |
| 292 | Klinikum Oldenburg AöR | Oldenburg | Germany | 26133 | |
| 293 | Frauenklinik St. Louise - St. Vincenz- Krankenhaus GmbH | Paderborn | Germany | 33098 | |
| 294 | Klinikum Ernst von Bergmann | Potsdam | Germany | 14467 | |
| 295 | Studienzentrum Onkologie Ravensburg | Ravensburg | Germany | 88212 | |
| 296 | Oncologianova GmbH | Recklinghausen | Germany | 45659 | |
| 297 | RoMed Klinikum Rosenheim | Rosenheim | Germany | 83022 | |
| 298 | Univ-Hospital, Dept Ob/Gyn | Rostock | Germany | 18059 | |
| 299 | CaritasKlinikum St. Theresia | Saarbrücken | Germany | 66113 | |
| 300 | Onkologische Schwerpunktpraxis Speyer | Speyer | Germany | 67346 | |
| 301 | G.SUND Gynäkologie Kompetenzzentrum | Stralsund | Germany | 18435 | |
| 302 | KKH Torgau | Torgau | Germany | 04860 | |
| 303 | Klinikum Mutterhaus | Trier | Germany | 54290 | |
| 304 | Praxisnetzwerk Hämatologie/Internistische Onkologie | Troisdorf | Germany | 53840 | |
| 305 | Frauenklinik | Tuebingen | Germany | 91054 | |
| 306 | Universitätsfrauenklinik Ulm | Ulm | Germany | 89081 | |
| 307 | Schwarzwald - Baar Klinikum Frauenklinik | Villingen-Schwenningen | Germany | 78052 | |
| 308 | Harzklinikum Dorothea Christiane Erxleben | Wernigerode | Germany | 06484 | |
| 309 | St. Anna Hospital Brustzentrum | Witten | Germany | 44649 | |
| 310 | Klinikum Worms gGmbH | Worms | Germany | 67550 | |
| 311 | General Hospital of Athens Alexandra Clinic | Athens | Attiki | Greece | 11528 |
| 312 | University General Hospital of Heraklion | Heraklion | Crete | Greece | 71110 |
| 313 | University General Hospital of Patras | Patras | Western Greece | Greece | 265 04 |
| 314 | General Hospital of Patras Agios Andreas | Patras | Greece | 26335 | |
| 315 | Pamela Youde Nethersole Eastern Hospital PYNEH | Hong Kong | Hong Kong | 10101 | |
| 316 | The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH) | Hong Kong | Hong Kong | 999077 | |
| 317 | The University of Hong Kong (HKU) - Queen Mary Hospital (QMH) | Pok Fu Lam | Hong Kong | 10101 | |
| 318 | Saint Vincents University Hospital | Dublin | Ie-d | Ireland | 4 |
| 319 | St. James Hospital | Dublin | Leinster | Ireland | D8 |
| 320 | University College Cork | Cork | Ireland | T12 YN60 | |
| 321 | Mater Misericordiae University Hospital | Dublin | Ireland | 7 | |
| 322 | University Hospital Limerick | Limerick | Ireland | V94 F858 | |
| 323 | Soroka MC | Be'er Sheva | Hadarom | Israel | 8410101 |
| 324 | Sheba Medical Center | Ramat Gan | Tel Aviv | Israel | 5262100 |
| 325 | Hadassah Medical Center | Jerusalem | Israel | 91120 | |
| 326 | Shaare Zedek Medical Center | Jerusalem | Israel | ||
| 327 | Rabin Medical Center | Petah tikva | Israel | 49100 | |
| 328 | Azienda Ospedaliera Garibaldi-Nesima | Catania | CT | Italy | 95122 |
| 329 | Istituto Europeo di Oncologia | Milan | MI | Italy | 20141 |
| 330 | Clinica Oncologica, Ospedali Riuniti Umberto 1 | Ancona | Italy | 60126 | |
| 331 | Centro di Riferimento Oncologico di Aviano - SOC Oncologia Medica e Prevenzione Oncologica | Aviano | Italy | 33081 | |
| 332 | Istituto Oncologico di Bari | Bari | Italy | 70124 | |
| 333 | Azienda ULSS n. 1 Dolomiti | Belluno | Italy | 32100 | |
| 334 | Policlinico S.Orsola-Malpighi SSD Oncologia Medica Addarii | Bologna | Italy | 40138 | |
| 335 | SSD Oncologia Medica | Bologna | Italy | 40138 | |
| 336 | Presidio Ospedaliero di Summa - Antonio Perrino | Brindisi | Italy | 72100 | |
| 337 | Istitutoperla Ricercaela Curadel Cancro IRCC | Candiolo | Italy | 10060 | |
| 338 | Istituto Naz per la Ricerca sul Cancro (IST) Genov | Genova | Italy | 16132 | |
| 339 | Area Vasta Sud Est Sede Operativa Grosseto | Grosseto | Italy | 58100 | |
| 340 | Azienda Usl Toscana sud est | Grosseto | Italy | 58100 | |
| 341 | IRCCS Ospedale San Raffaele | Milano | Italy | 20132 | |
| 342 | University Hospital of Modena | Modena | Italy | 41122 | |
| 343 | INT Fondazione Pascale | Napoli | Italy | 80131 | |
| 344 | Istituto Oncologico Veneto IRCCS | Padova | Italy | 35128 | |
| 345 | ICS Maugeri IRCCS | Pavia | Italy | 27100 | |
| 346 | Azienda Ospedaliera di Perugia | Perugia | Italy | 06132 | |
| 347 | A.O.U. Citta della Salute e della Scienza di Torino | Torino | Italy | 10126 | |
| 348 | Hyogo Cancer Center | Akashi City | Japan | 673-8558 | |
| 349 | National Cancer Center (NCC) - Tsukiji Campus - National Cancer Center Hospital (NCCH) | Chuo-Ku | Japan | 104-0045 | |
| 350 | National Hospital Organization - National Kyushu Cancer Center | Fukuoka City | Japan | 811-1395 | |
| 351 | Hiroshima City Hiroshima Citizens Hospital | Hiroshima City | Japan | 730-8518 | |
| 352 | Tokai University Hospital - Isehara Campus | Isehara City | Japan | 253-0036 | |
| 353 | Sagara Hospital | Kagoshima City | Japan | 892-0833 | |
| 354 | National Cancer Center Hospital East (NCCHE) - Kashiwa Campus | Kashiwa City | Japan | 277-8577 | |
| 355 | Japanese Foundation for Cancer Research (JFCR) - The Cancer Institute Hospital - Breast Oncology Center | Koto-Ku | Japan | 135-8550 | |
| 356 | Kyoto University Hospital | Kyoto | Japan | 606-8507 | |
| 357 | National Hospital Organization (NHO) - Shikoku Cancer Center | Matsuyama City | Japan | 791-0280 | |
| 358 | Aichi Cancer Center Hospital | Nagoya City | Japan | 464-8681 | |
| 359 | Niigata Cancer Center Hospital | Niigata City | Japan | 951-8133 | |
| 360 | Hyogo College of Medicine Hospital | Nishinomiya City | Japan | 663-8501 | |
| 361 | Okayama University Hospital | Okayama City | Japan | 700-8558 | |
| 362 | National Hospital Organization - Osaka National Hospital (ONH) | Osaka City | Japan | 540-0006 | |
| 363 | Osaka International Cancer Institute (OICI) | Osaka City | Japan | 541-8567 | |
| 364 | Saitama Cancer Center | Saitama | Japan | 362-0806 | |
| 365 | National Hospital Organization - Hokkaido Cancer Center | Sapporo City | Japan | 003-0804 | |
| 366 | Kindai University (Kinki University) - Faculty of Medicine (Kinki University School of Medicine (KUSM)) - Kindai University Hospital (Kinki University Hospital) - Cancer Center | Sayama City | Japan | 589-8511 | |
| 367 | Tohoku University Hospital (TUH) - Clinical Research, Innovation and Education Center (CRIETO) | Sendai City | Japan | 980-8574 | |
| 368 | Showa University Hospital - Breast Center | Shinagawa-Ku | Japan | 1428666 | |
| 369 | Tokyo Medical University Hospital | Shinjuku-Ku | Japan | 160-0023 | |
| 370 | Shizuoka Cancer Center (SCC) | Shizuoka | Japan | 411-8777 | |
| 371 | Kanagawa Cancer Center Hospital - Kanagawa Cancer Center (Kanagawa Cancer Centre Research Institute) | Yokohama City | Japan | 241-8515 | |
| 372 | Kyungpook National University Hospital | Daegu | Korea, Republic of | 41944 | |
| 373 | National Cancer Center | Gyeonggi-do | Korea, Republic of | 10408 | |
| 374 | CHA Bundang Medical Center CHA University | Gyeonggi-do | Korea, Republic of | 13496 | |
| 375 | Seoul National University Bundang Hospital | Gyeonggi-do | Korea, Republic of | 13620 | |
| 376 | Gachon University Gil Medical Center | Incheon | Korea, Republic of | 21565 | |
| 377 | Samsung Medical Center | Irwon-dong | Korea, Republic of | 06351 | |
| 378 | Korea University Anam Hospital | Seoul | Korea, Republic of | 02841 | |
| 379 | Seoul National University Hospital | Seoul | Korea, Republic of | 03080 | |
| 380 | Severance Hospital | Seoul | Korea, Republic of | 03722 | |
| 381 | Asan Medical Center | Songpa-gu | Korea, Republic of | 05505 | |
| 382 | Soon Chun Hyang Central Medical Center (SCHMC) | Yongsan | Korea, Republic of | 330-721 | |
| 383 | Clinstile SA de CV | Ciudad de mexico | Cdmx | Mexico | 06700 |
| 384 | CIMAB S.A. de C.V | Torreon | Coahuila | Mexico | 27000 |
| 385 | Hospital Civil de Guadalajara Fray Antonio Alcalde | Guadalajara | JAL | Mexico | 44280 |
| 386 | Consultorio del Dr. Joaqun Gabriel Reinoso Toledo | Monterrey | Nuevo Leon | Mexico | 64320 |
| 387 | Amsterdam UMC - VU Medisch Centrum | Amsterdam | Noord-Holland | Netherlands | 1081 HZ |
| 388 | Amphia Hospital Breda | Breda | Netherlands | 4800 RK | |
| 389 | Erasmus MC - Daniel den Hoed Oncologisch Centrum | Rotterdam | Netherlands | 3000 CA | |
| 390 | Hospital Nacional Arzobispo Loayza | Lima | Peru | 15082 | |
| 391 | Clinica Ricardo Palma | Lima | Peru | Lima 27 | |
| 392 | Instituto Nacional de Enfermedades Neoplasicas INEN | Lima | Peru | Lima 34 | |
| 393 | Centro de Investigación Clinica Trujillo EIRL | Trujillo | Peru | 13001 | |
| 394 | SP Zoz Opolskie Centrum Onkologii IM | Opole | Opolskie | Poland | 45-061 |
| 395 | Uniwersyteckie Centrum Kliniczne | Gdańsk | Pomorskie | Poland | 80-211 |
| 396 | Centrum Medyczne HCP Sp. z o.o. | Poznań | Wielkopolskie | Poland | 61-485 |
| 397 | MSCM Cancer Center and Institute of Oncology Department of Breast Cancer and Reconstructive Surgery | Warsaw | Poland | 02-781 | |
| 398 | Instytut Centrum Zdrowia Matki Polki | Łódź | Poland | 93-338 | |
| 399 | Hospital da Senhora da Oliveira, Guimarães EPE | Guimarães | Portugal | 4835-044 | |
| 400 | Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE | Lisboa | Portugal | 1099-023 | |
| 401 | Fundação Champalimaud | Lisboa | Portugal | 1400-038 | |
| 402 | Centro Hospitalar de Lisboa Ocidental, EPE | Lisboa | Portugal | 1449-005 | |
| 403 | Hospital da Luz | Lisboa | Portugal | 1500-650 | |
| 404 | Hospital CUF Descobertas | Lisboa | Portugal | 1998-018 | |
| 405 | Hospital Beatriz Ângelo | Loures | Portugal | 2674-514 | |
| 406 | Unidade Local de Saúde de Matosinhos, EPE | Matosinhos | Portugal | 4464-513 | |
| 407 | Instituto Português de Oncologia do Porto Francisco Gentil, EPE | Porto | Portugal | 4200-072 | |
| 408 | Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE | Vila Nova De Gaia | Portugal | 4434-502 | |
| 409 | Institutul Oncologic Prof. Dr. Ion Chiricuta | Cluj-Napoca | Cluj | Romania | 400015 |
| 410 | Onco Clinic Consult SA | Craiova | Dolj | Romania | 200103 |
| 411 | Centrul de Oncologie Sfantu Nectarie | Craiova | Dolj | Romania | 200347 |
| 412 | Institutul Oncologic Bucuresti IOB | Bucharest | Romania | 22328 | |
| 413 | State Budget Healthcare Institution of Stavropol Region | Pyatigorsk | Stavropol Region | Russian Federation | 357502 |
| 414 | SBHI Arkhangelsk Region - Arkhangelsk Clinical Oncological Dispensary | Arkhangel'sk | Russian Federation | 163045 | |
| 415 | State Budgetary Healthcare Institution Oncological Dispensary No. 2 of the Ministry of Health of Krasnodar Region | Sochi | Russian Federation | 354057 | |
| 416 | National University Cancer Institute | Singapore | Singapore | 119074 | |
| 417 | National Cancer Center Singapore | Singapore | Singapore | 169610 | |
| 418 | Hospital Universitario de Basurto | Bilbao | Bizkaia | Spain | 48013 |
| 419 | Hospital Clínico Universitario Virgen de la Arrixaca | El Palmar | Murcia | Spain | 30120 |
| 420 | Vithas Xanit International Hospital | Benalmádena | Málaga | Spain | 29630 |
| 421 | Hospital Universitario Sant Joan Reus | Reus | Tarragona | Spain | 43204 |
| 422 | Hospital Universitario Fundación Alcorcón | Alcorcón | Spain | 28922 | |
| 423 | Hospital General Universitario de Alicante | Alicante | Spain | 03010 | |
| 424 | Hospital Universitario de Torrevieja | Alicante | Spain | 03186 | |
| 425 | Hospital de San Juan de Alicante | Alicante | Spain | 03550 | |
| 426 | Hospital Universitario de Badajoz | Badajoz | Spain | ||
| 427 | Hospital del Mar | Barcelona | Spain | 08003 | |
| 428 | IOB Institute Of Oncology-Hospital Quironsalud Barcelona | Barcelona | Spain | 08023 | |
| 429 | Hospital Universitari Vall d'Hebron | Barcelona | Spain | 08035 | |
| 430 | Hospital Clínic de Barcelona | Barcelona | Spain | 08036 | |
| 431 | Hospital Universitari Mútua Terrassa | Barcelona | Spain | 08221 | |
| 432 | ALTHAIA, Xarxa Assistencial Universitària de Manresa F.P. | Barcelona | Spain | 08243 | |
| 433 | Hospital de Mataró | Barcelona | Spain | 08304 | |
| 434 | ICO Hospitalet | Barcelona | Spain | 08907 | |
| 435 | ICO Badalona | Barcelona | Spain | 2050 | |
| 436 | Consorcio Hospitalario Provincial de Castelló | Castelló | Spain | 12002 | |
| 437 | Complejo Hospitalario Universitario A Coruña (CHUA) | Coruña | Spain | 15006 | |
| 438 | Hospital Universitario San Pedro de Alcantara | Cáceres | Spain | 10001 | |
| 439 | ICO Girona | Girona | Spain | 17007 | |
| 440 | Hospital Universitario Clínico San Cecilio | Granada | Spain | 18016 | |
| 441 | Complejo Hospitalario de Jaen | Jaén | Spain | 23007 | |
| 442 | Complejo Asistencial Universitario de León | León | Spain | 24001 | |
| 443 | Hospital Arnau de Vilanova de Lleida | Lleida | Spain | 25198 | |
| 444 | Clinica Universidad De Navarra, Madrid | Madrid | Spain | 28027 | |
| 445 | Hospital MD Anderson Cancer Center Madrid | Madrid | Spain | 28033 | |
| 446 | Hospital Universitario Ramón y Cajal | Madrid | Spain | 28034 | |
| 447 | Hospital Universitario Fundación Jiménez Díaz | Madrid | Spain | 28040 | |
| 448 | Hospital Universitario 12 de Octubre | Madrid | Spain | 28041 | |
| 449 | Hospital Universitario La Paz | Madrid | Spain | 28046 | |
| 450 | HM Sanchinarro (CIOCC) | Madrid | Spain | 28050 | |
| 451 | Hospital Universitario Puerta de Hierro de Majadahonda | Madrid | Spain | 28222 | |
| 452 | Hospital Universitario HM Puerta del Sur | Madrid | Spain | 28938 | |
| 453 | Hospital Universitario de Fuenlabrada | Madrid | Spain | 28942 | |
| 454 | Hospital General Universitario Morales Meseguer | Murcia | Spain | 30008 | |
| 455 | Hospital Universitario Virgen de la Victoria | Málaga | Spain | 29010 | |
| 456 | Hospital Universitario Rey Juan Carlos | Móstoles | Spain | 28933 | |
| 457 | Complejo Hospitalario de Navarra | Navarro | Spain | 31008 | |
| 458 | Hospital Universitari Son Espases | Palma De Mallorca | Spain | 07120 | |
| 459 | Hospital Son Llatzer | Palma De Mallorca | Spain | 07198 | |
| 460 | Hospital Universitario de Canarias | San Cristobal de la Laguna | Spain | 38320 | |
| 461 | Hospital General de Catalunya | Sant Cugat Del Vallès | Spain | 08195 | |
| 462 | Complejo Hospitalario Clínico Universitario de Santiago de Compostela (CHUS) | Santiago De Compostela | Spain | 15706 | |
| 463 | Hospital Universitario Virgen Macarena | Sevilla | Spain | 41009 | |
| 464 | Hospital Quirón Salud Sagrado Corazón | Sevilla | Spain | 41013 | |
| 465 | Hospital Universtiario Virgen del Rocio | Sevilla | Spain | 41013 | |
| 466 | Fundación Instituto Valenciano de Oncologia (IVO) | Valencia | Spain | 46009 | |
| 467 | Hospital Clínico Universitario de Valencia | Valencia | Spain | 46010 | |
| 468 | Hospital Arnau de Vilanova de Valencia | Valencia | Spain | 46015 | |
| 469 | Hospital Clínico Universitario Lozano Blesa | Zaragoza | Spain | 50009 | |
| 470 | E-Da Cancer Hospital | Kaohsiung | Yanchao District | Taiwan | 82445 |
| 471 | Koo Foundation Sun Yat-Sen Cancer Center | Beitou | Taiwan | 112 | |
| 472 | Changhua Christian Hospital (CCH) | Chang Hua | Taiwan | 50006 | |
| 473 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung | Taiwan | 80756 | |
| 474 | China Medical University Hospital | Taichung | Taiwan | 40447 | |
| 475 | Taichung Veterans General Hospital | Taichung | Taiwan | 40705 | |
| 476 | National Cheng Kung University Hospital | Tainan | Taiwan | 704 | |
| 477 | Chi Mei Medical Center CMMC - Yongkang Branch | Tainan | Taiwan | 71004 | |
| 478 | National Taiwan University Hospital NTUH | Taipei | Taiwan | 10002 | |
| 479 | MacKay Memorial Hospital | Taipei | Taiwan | 10449 | |
| 480 | Taipei Veterans General Hospital TPVGH | Taipei | Taiwan | 111217 | |
| 481 | Tri-Service General Hospital | Taipei | Taiwan | 114 | |
| 482 | Chang Gung Memorial Hospital CGMH | Taipei | Taiwan | 33305 | |
| 483 | Hacettepe University Cancer Institute | Ankara | İç Anadolu | Turkey | 6100 |
| 484 | Trakya University Medical Faculty | Edirne | Turkey | 22030 | |
| 485 | Istanbul Medeniyet University Medical Faculty | Istanbul | Turkey | 34093 | |
| 486 | Medical Park - Izmir Hastanesi | İzmir | Turkey | 35575 | |
| 487 | Peterborough City Hospital | Peterborough | Cambridgeshire | United Kingdom | PE3 9NZ |
| 488 | Kent Oncology Centre Maidstone Hospital | Maidstone | Kent | United Kingdom | ME16 9QQ |
| 489 | The Christie Hospital | Manchester | Lancashire | United Kingdom | M20 4XB |
| 490 | Clatterbridge Cancer Centre | Wirral | Merseyside | United Kingdom | CH63 4JY |
| 491 | Nottingham University Hospitals | Nottingham | Nottinghamshire | United Kingdom | NG5 1PB |
| 492 | Royal United Hospital Bath NHS Trust - Royal United Hospital RUH | Bath | Somerset | United Kingdom | BA1 3NG |
| 493 | Somerset NHS Foundation Trust | Taunton | Somerset | United Kingdom | TA1 5DA |
| 494 | St. James University Hospital | Leeds | West Yorkshire | United Kingdom | LS9 7TF |
| 495 | Colchester Hospital, East Suffolk & North Essex NHS Foundation Trust | Colchester | United Kingdom | CO4 5JL | |
| 496 | Royal Devon Exeter NHS Foundation Trust | Exeter | United Kingdom | EX2 5DW | |
| 497 | Beatson West of Scotland Cancer Centre | Glasgow | United Kingdom | G12 0YN | |
| 498 | Guys and St Thomas NHS Foundation Trust | London | United Kingdom | SE1 9RT | |
| 499 | Charing Cross Hospital | London | United Kingdom | W6 8RF | |
| 500 | Oxford University Hospitals NHS Foundation Trust | Oxford | United Kingdom | OX3 7LJ | |
| 501 | Blackpool Victoria Hospital | Peterborough | United Kingdom | FY3 8NR |
Sponsors and Collaborators
- Daiichi Sankyo, Inc.
- AstraZeneca
- NSABP Foundation Inc
- German Breast Group
- Spanish Breast Cancer Research Group (SOLTI)
Investigators
- Study Director: Global Clinical Leader, Daiichi Sankyo, Inc.
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Daiichi Sankyo, Inc.
ClinicalTrials.gov Identifier:
NCT04622319
Other Study ID Numbers:
- DS8201-A-U305
- 2020-003982-20
- DESTINY-Breast05
- NSABP B-60
- GBG-103
- SOLTI-2001
First Posted:
Nov 9, 2020
Last Update Posted:
Aug 19, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Daiichi Sankyo, Inc.
Additional relevant MeSH terms: