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Heredity of Retinal Vessel Tortuosity

Sponsor
Glostrup University Hospital, Copenhagen (Other)
Overall Status
Completed
CT.gov ID
NCT00427063
Collaborator
Juvenile Diabetes Research Foundation (Other)
218
Enrollment
1
Location
11
Duration (Months)
19.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Other
    Official Title:
    Heredity of Retinal Vessel Tortuosity - A Twin Study
    Study Start Date :
    Jan 1, 1998
    Study Completion Date :
    Dec 1, 1998

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      20 Years to 46 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Samesex twin pairs of self-assessed good health
      Exclusion Criteria:

      • Diabetes mellitus

      • Hypertension

      • Thyroid disease

      • Cataract or other opacities of the refractive media

      • Missing fundus photographs

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Department of Ophthalmology Glostrup Hospital Glostrup Copenhagen County Denmark DK-2600

      Sponsors and Collaborators

      • Glostrup University Hospital, Copenhagen
      • Juvenile Diabetes Research Foundation

      Investigators

      • Principal Investigator: Michael Larsen, Prof. MD, Department of Ophthalmology Glostrup Hospital University of Copenhagen

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00427063
      Other Study ID Numbers:
      • Danish Twin Registry 1998
      First Posted:
      Jan 26, 2007
      Last Update Posted:
      Jan 26, 2007
      Last Verified:
      Jan 1, 2007
      Keywords provided by , ,
      retinal vessels
      tortuosity
      Additional relevant MeSH terms:
      Retinopathy of Prematurity

      Study Results

      No Results Posted as of Jan 26, 2007