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Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members

Sponsor
University of California, San Diego (Other)
Overall Status
Recruiting
CT.gov ID
NCT01643512
Collaborator
(none)
500
Enrollment
1
Location
120
Duration (Months)
4.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors. NAFLD is often associated with the traits of the metabolic syndrome including diabetes, high cholesterol or elevated blood pressure. Currently, there are no accurate noninvasive means of evaluating NAFLD and its more serious form which includes inflammation that may lead to severe scarring in the liver. The goal of this study is to evaluate shared genetic factors that underlie NAFLD and features of the metabolic syndrome as determined by blood work and radiographic studies in a cohort of twins and first degree relatives.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Following an information session during which the primary consent document, a genetic sampling consent document and the UCSD HIPPA forms are reviewed, discussed and signed, the following tests and procedures will be done. For each subject, the study visit will be for 3-4 hours.

    1. Subjects will undergo a detailed history, physical examination, anthropometrics and vital signs including blood pressure and pulse. Standardized questionnaires including the Alcohol Use Disorders Identification Tests (AUDIT) and Skinner Lifetime Drinking History will be used to identify alcohol use as a cause of fatty liver disease. A trained investigator will measure waist/hip ratio at the same time as other measures are taken. The Body Mass Index (BMI) will be as calculated by measuring each subject's weight (Kg) and height (m) with empty bowel and bladder and using the formula: BMI = weight (kg)/ height (m)2.

    2. Blood tests: Participants will undergo phlebotomy, after an overnight fast, for complete metabolic panel (including liver function tests), complete blood count, protime, lipid panel, free fatty acids, serum insulin, hemoglobin A1C, fasting glucose, hepatitis B surface antigen, hepatitis C antibody, prothrombin time and HIV. 30ml of blood will be collected: including 5ml of serum banking, 5ml of plasma banking, 5ml of DNA banking, and 15ml for planned labs as listed above. Plasma will be stored for adipocytokines and testing of novel genes or biomarkers for NALFD in later studies. Fasting plasma glucose and plasma insulin levels will be obtained. Insulin resistance will be measured by HOMA-IR, the homeostasis assessment model of insulin resistance, where HOMA-IR (mmol/L x µU/ml) = fasting glucose (mmol/L) x fasting insulin (µU/ml)/22.5). The participants will be required to provide a stool and urine sample as well.

    3. A urine pregnancy test will be performed for all women of childbearing age. Women who have had hysterectomies are excluded from pregnancy testing. If the pregnancy test is positive, the patient will not be enrolled in the study.

    4. The patient will undergo magnetic resonance imaging for hepatic fat fraction.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    500 participants
    Observational Model:
    Family-Based
    Time Perspective:
    Cross-Sectional
    Official Title:
    Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members
    Study Start Date :
    Aug 1, 2011
    Anticipated Primary Completion Date :
    Aug 1, 2021
    Anticipated Study Completion Date :
    Aug 1, 2021

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 100 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      1. Subjects must be at least 18 years of age

      2. The subject is willing and able to complete all procedures and observations specified in the protocol

      3. The subject has been fully informed and has personally signed and dated the written Informed Consent/Assent and Health Insurance Portability and Accountability Act (HIPAA) provisions.

      Exclusion Criteria:

      1. The subject is a female who is pregnant or nursing.

      2. Contraindications to MRI:

      • The subject has any contraindication to MR imaging, such as patients with pacemakers, metallic cardiac valves, magnetic material such as surgical clips, implanted electronic infusion pumps or other conditions that would preclude proximity to a strong magnetic field.

      • The subject has a history of extreme claustrophobia.

      • The subject cannot fit inside the MR scanner cavity

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University of California, San Diego San Diego California United States 92103

      Sponsors and Collaborators

      • University of California, San Diego

      Investigators

      • Principal Investigator: Rohit Loomba, UCSD

      Study Documents (Full-Text)

      None provided.

      More Information

      Additional Information:

      Publications

      None provided.
      Responsible Party:
      Rohit Loomba, Professor, University of California, San Diego
      ClinicalTrials.gov Identifier:
      NCT01643512
      Other Study ID Numbers:
      • 111282
      First Posted:
      Jul 18, 2012
      Last Update Posted:
      May 6, 2021
      Last Verified:
      May 1, 2021
      Additional relevant MeSH terms:
      Liver Diseases
      Fatty Liver

      Study Results

      No Results Posted as of May 6, 2021