Effect of Stress on Heroin-Related Memory Retrieval
Sponsor
National Institute on Drug Dependence, China (Other)
Overall Status
Completed
CT.gov ID
NCT00759005
Collaborator
(none)
1
1
18.1
Study Details
Study Description
Brief Summary
The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Study Start Date
:
Mar 1, 2007
Actual Primary Completion Date
:
Jun 1, 2008
Actual Study Completion Date
:
Sep 1, 2008
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: A, 4
|
Drug: propranolol and cortisol
|
Outcome Measures
Primary Outcome Measures
- Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts []
Eligibility Criteria
Criteria
Ages Eligible for Study:
20 Years
to 40 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.
Exclusion Criteria:
- current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Institute on Drug Dependence | Beijing | Beijing | China | 100191 |
Sponsors and Collaborators
- National Institute on Drug Dependence, China
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00759005
Other Study ID Numbers:
- NIDD
First Posted:
Sep 25, 2008
Last Update Posted:
Sep 25, 2008
Last Verified:
Sep 1, 2008