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HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers

Sponsor
Future University in Egypt (Other)
Overall Status
Completed
CT.gov ID
NCT05325918
Collaborator
(none)
14
Enrollment
1
Location
5.1
Actual Duration (Months)
2.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Peri -implant crevicular fluid was obtained from seven smoker patients and then compared to peri-implant crevicular fluid from seven non smoker individuals.

    The peri-implant crevicular fluid was obtained using periopaper strips then analyzed using ELISA kits of these markers; HIF-1 Alpha, VEGF and MMP-8

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    14 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    HIF-1 Alpha, VEGF and MMP-8 Levels in Peri-implant Crevicular Fluid of Smokers Versus Non Smokers
    Actual Study Start Date :
    Aug 29, 2021
    Actual Primary Completion Date :
    Jan 15, 2022
    Actual Study Completion Date :
    Jan 30, 2022

    Outcome Measures

    Primary Outcome Measures

    1. Measurement of levels of HIF-1 Alpha, VEGF and MMP-8 in peri-implant crevicular fluid [Baseline]

      Markers collected using periopaper strips

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 50 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Medically free patients

    • Individuals with restored implants placed one year or more before study enrollment

    • Both genders

    • Age range 20-50 years old

    Exclusion Criteria:

    • Pregnant Females

    • Lactating females

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Faculty of oral and dental medicine,FUE, Cairo,Egypt Cairo Egypt 11835

    Sponsors and Collaborators

    • Future University in Egypt

    Investigators

    • Principal Investigator: Sarah M Elkot, Lecturer, Lecturer of Oral Medicine and Periodontology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Sarah Elkot, Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt., Future University in Egypt
    ClinicalTrials.gov Identifier:
    NCT05325918
    Other Study ID Numbers:
    • FUE13
    First Posted:
    Apr 13, 2022
    Last Update Posted:
    Apr 14, 2022
    Last Verified:
    Apr 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Undecided
    Plan to Share IPD:
    Undecided
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Sarah Elkot, Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt., Future University in Egypt
    gingival crevicular fluid
    Smoking
    inflammation
    Additional relevant MeSH terms:
    Peri-Implantitis

    Study Results

    No Results Posted as of Apr 14, 2022