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High-field Brain Magnetic Resonance Spectroscopy

Sponsor
University of Minnesota (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT02053701
Collaborator
National Institute for Biomedical Imaging and Bioengineering (NIBIB) (NIH)
30
Enrollment
1
Location
245
Anticipated Duration (Months)
0.1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").

The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).

Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.

Aims

  1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).

  2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).

Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    30 participants
    Observational Model:
    Other
    Time Perspective:
    Other
    Official Title:
    Technical Developments for High-field Brain Magnetic Resonance Spectroscopy
    Actual Study Start Date :
    Jun 1, 2010
    Anticipated Primary Completion Date :
    Nov 1, 2030
    Anticipated Study Completion Date :
    Nov 1, 2030

    Outcome Measures

    Primary Outcome Measures

    1. Precision of quantification of brain metabolites concentrations [One time only]

      This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • over 18 years old
    Exclusion Criteria:
    • no metallic implant or other MRI-incompatible device

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Center for Magnetic Resonance Research Minneapolis Minnesota United States 55455

    Sponsors and Collaborators

    • University of Minnesota
    • National Institute for Biomedical Imaging and Bioengineering (NIBIB)

    Investigators

    • Principal Investigator: Pierre-Gilles Henry, PhD, Center for Magnetic Resonance Research, University of Minnesota

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    University of Minnesota
    ClinicalTrials.gov Identifier:
    NCT02053701
    Other Study ID Numbers:
    • 1210M23141
    • P41EB015894
    First Posted:
    Feb 4, 2014
    Last Update Posted:
    Mar 18, 2022
    Last Verified:
    Mar 1, 2022
    Keywords provided by University of Minnesota
    magnetic resonance spectroscopy
    quantification precision
    brain
    brain metabolites

    Study Results

    No Results Posted as of Mar 18, 2022