The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula
Study Details
Study Description
Brief Summary
The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.
The main questions it aims to answer are:
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What factors contribute to the failure of HFNC treatment in these children?
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What is the frequency of HFNC treatment failure in children with moderate and severe respiratory distress? Researchers will compare the group whose HFNC treatment was successful with the group whose HFNC treatment failed to identify factors that cause treatment failure.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
Oxygen therapy with a high-flow nasal cannula (HFNC) is a well-tolerated, relatively new, non-invasive alternative ventilation treatment modality. On the other hand, HFNC failure delays advanced respirator supportive treatments, prolongs hospitalization in the intensive care unit, and emergency department, and causes a significant increase in morbidity and mortality with hypoxemia, neurological impairment, and/or hemodynamic instability. The investigators aimed to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Successful Patients who do not need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) |
|
| Failure Patients who need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) |
Outcome Measures
Primary Outcome Measures
- HFNC treatment outcome (failure or success) [30 days]
Whether advanced respiratory support treatments (invasive and noninvasive mechanical ventilation) are needed
Eligibility Criteria
Criteria
Inclusion Criteria:
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Moderate to severe respiratory distress
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Oxygen therapy with high-flow nasal cannula
Exclusion Criteria:
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Chronic lung disease (those with CO2 retention or hypoxia in their daily life)
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Cyanotic congenital heart disease
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Craniofacial malformation
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Trauma patients
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Hypotonic patients
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Cases with tracheostomy
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Patients using HFNC therapy for respiratory support after extubation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Dr Behcet Uz Children's Hospital | İzmir | Turkey |
Sponsors and Collaborators
- Dr. Behcet Uz Children's Hospital
Investigators
- Principal Investigator: Derşan Onur, Dr. Behcet Uz Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Er A, Caglar A, Akgul F, Ulusoy E, Citlenbik H, Yilmaz D, Duman M. Early predictors of unresponsiveness to high-flow nasal cannula therapy in a pediatric emergency department. Pediatr Pulmonol. 2018 Jun;53(6):809-815. doi: 10.1002/ppul.23981. Epub 2018 Mar 12.
- Liu J, Li D, Luo L, Liu Z, Li X, Qiao L. Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case-control study. Front Pediatr. 2022 Aug 23;10:979944. doi: 10.3389/fped.2022.979944. eCollection 2022.
- Sunkonkit K, Kungsuwan S, Seetaboot S, Reungrongrat S. Factors associated with failure of using high flow nasal cannula in children. Clin Respir J. 2022 Nov;16(11):732-739. doi: 10.1111/crj.13533. Epub 2022 Aug 29.
- HFNC failure