Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

• Sponsor: Keimyung University Dongsan Medical Center (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT03259672
• Collaborator: (none)
• Enrollment: 100
• Arms: 2
• Anticipated Duration (Months): 13

Study Details

Study Description

Brief Summary

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Condition or Disease	Intervention/Treatment	Phase
Hip Arthroplasty	Drug: Sevoflurane; Drug: Desflurane	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 100 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Triple (Participant, Investigator, Outcomes Assessor)
• Primary Purpose: Prevention
• Official Title: Influence of Sevoflurane and Desflurane on Postoperative Sore Throat
• Anticipated Study Start Date: Oct 1, 2017
• Anticipated Primary Completion Date: Oct 1, 2018
• Anticipated Study Completion Date: Nov 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Sevoflurane	Drug: Sevoflurane; Sevoflurane was used as a maintenance anesthetic agent.
Experimental: Desflurane	Drug: Desflurane; Desflurane was used as a maintenance anesthetic agent.

Outcome Measures

Primary Outcome Measures

1. Number of participants with postoperative sore throat [At 24 hr]

Secondary Outcome Measures

1. Number of participants with postoperative sore throat [At 0, 2, 4 and 24 hr]

2. Number of participants with postoperative hoarseness [At 0, 2, 4 and 24 hr]

3. Number of participants with postoperative cough [At 0, 2, 4 and 24 hr]

4. Number of participants with postoperative nausea [At 0, 2, 4 and 24 hr]

5. Number of participants with postoperative vomiting [At 0, 2, 4 and 24 hr]

6. Number of participants with additional pain medication [At 0, 2, 4 and 24 hr]

7. Visual analogue scale of postoperative pain [At 0, 2, 4 and 24 hr]

8. Number of participants with shivering [At 0, 2, 4 and 24 hr]

9. Requirements of analgesics [At 0, 2, 4 and 24 hr]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• ASA I-III

• Patients scheduled for general anesthesia with endotracheal intubation

Exclusion Criteria:

• Difficult airway

• Friable teeth

• Rapid sequence induction

• Recent sore throat

• Recent upper respiratory infection

• Asthma

• Chronic obstructive pulmonary disease

• Chronic cough

• Arrhythmia

• Coronary disease

• Heart failure

• Pregnancy

• Allergy to sevoflurane

• Allergy to desflurane

• Fever after halogenated anesthetics

• Jaundice after halogenated anesthetics

• Malignant hyperthremia

• Allergy to remifentanil

• Friable teeth

• History of head and neck surgery

• Multiple intubation attempts

• Regional anesthetic agents

• Gastric tube

• Dexamethasone

• Severe hypovolemia

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Keimyung University Dongsan Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Hyun-Chang Kim, Assistant professor, Keimyung University Dongsan Medical Center
• ClinicalTrials.gov Identifier: NCT03259672
• Other Study ID Numbers: SevoDesPOST
• First Posted: Aug 24, 2017
• Last Update Posted: Aug 24, 2017
• Last Verified: Aug 1, 2017

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Hyun-Chang Kim, Assistant professor, Keimyung University Dongsan Medical Center: intubation; pharyngitis; remifentanil
• Additional relevant MeSH terms: Pharyngitis; Sevoflurane; Desflurane

Study Results

No Results Posted as of Aug 24, 2017