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Study of Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

Sponsor
Imperial College London (Other)
Overall Status
Unknown status
CT.gov ID
NCT00733655
Collaborator
(none)
50
Enrollment
1
Location
143
Duration (Months)
0.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels. We propose to obtain small skin samples from patients with HHT in order to analyze the samples using histological methods, and study the properties of vascular endothelial cells derived from patients. We hypothesize that these cells will show altered growth, migration, and protein synthetic differences when compared to normal endothelial cells, which may be confirmed in single time point analyses in histological samples. We anticipate that that these findings may help to explain aspects of the HHT disease phenotype.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    50 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Study Start Date :
    Sep 1, 2008
    Anticipated Primary Completion Date :
    Aug 1, 2020
    Anticipated Study Completion Date :
    Aug 1, 2020

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • Patients with Hereditary Haemorrhagic Telangiectasia
      Exclusion Criteria:
      • Unable to provide informed consent

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Imperial College Hammersmith Campus London United Kingdom W12 0NN

      Sponsors and Collaborators

      • Imperial College London

      Investigators

      • Principal Investigator: Claire L Shovlin, Imperial College London

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Imperial College London
      ClinicalTrials.gov Identifier:
      NCT00733655
      Other Study ID Numbers:
      • IC/CLS5
      First Posted:
      Aug 13, 2008
      Last Update Posted:
      Apr 16, 2019
      Last Verified:
      Apr 1, 2019
      Additional relevant MeSH terms:
      Telangiectasis
      Telangiectasia, Hereditary Hemorrhagic

      Study Results

      No Results Posted as of Apr 16, 2019