Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID) (NIH)

Overall Status

Completed

CT.gov ID

NCT00039975

Collaborator

(none)

Enrollment

Locations

3.6

Patients Per Site

Study Details

Study Description

Brief Summary

Diltiazem CD and amlodipine are drugs used to treat heart disease and high blood pressure. The purpose of this study is to find out if these drugs interact with the anti-HIV drugs indinavir and ritonavir. The study will also look at the safety of taking the study drugs together.

Heart disease and high blood pressure are major health concerns for people with HIV. Standard treatment for these illnesses often includes calcium channel blockers (CCBs). There is a potential for significant drug interactions between CCBs and HIV protease inhibitors (PIs) that may influence the dosing, monitoring, and choosing of CCBs and PIs when used in people infected with HIV. This study will examine the drug interactions between 2 commonly used CCBs and the PI combination indinavir and ritonavir (IDV/RTV). This information should help doctors choose the appropriate treatment for high blood pressure or heart disease in people taking PIs.

Condition or Disease	Intervention/Treatment	Phase
HIV Infections Cardiovascular Diseases Hypertension	Drug: Indinavir sulfate Drug: Ritonavir Drug: Amlodipine Drug: Diltiazem HCl	Phase 1

Detailed Description

Ischemic cardiovascular disease and hypertension occur in persons with HIV infection, and the incidence and prevalence may increase over time as the infected population ages. Standard pharmacologic interventions for these illnesses often include calcium channel blockers (CCBs). Many of the calcium channel blockers are metabolized by cytochrome P450 3A4 (CYP 3A4), which is inhibited by some protease inhibitors (PIs). Thus, there is potential for clinically significant interactions between CCBs and PIs. The presence of significant drug-drug interactions may influence the dosing, monitoring, and choosing of CCBs and/or PIs when used in persons with HIV infection. Because of the potential concomitant use of CCBs with the PI combination IDV/RTV, this study will evaluate bi-directional drug-drug interactions between 2 commonly used CCBs and IDV/RTV. This information should assist clinicians in choosing the appropriate CCBs to treat hypertension or cardiovascular disease in persons taking PIs.

Patients are randomized to 1 of the following 2 arms:

Arm A: diltiazem CD interaction with IDV and RTV. Arm B: amlodipine interaction with IDV and RTV. From Days 1 to 7, patients take diltiazem CD (Arm A) or amlodipine (Arm B). Plasma is collected for PK over a 24-hour period beginning on Day 7. From Days 8 to 19, patients stop taking their assigned CCB and take IDV and RTV. Plasma is collected for PK over a 12-hour period on Day 19. From Days 20 to 26, patients continue to take IDV and RTV and add diltiazem CD (Arm A) or amlodipine (Arm B). Patients stop all 3 drugs after the last dose on Day 26. Plasma is collected for PK for a 24-hour period beginning on Day 26. Blood work, liver and kidney function tests, urinalysis, and an electrocardiogram (EKG) are performed at some visits.

Study Design

Study Type:

Interventional

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Evaluation of Potential Pharmacokinetic Interactions Between HIV Protease Inhibitors and Calcium Channel Blockers

Actual Study Completion Date :

Apr 1, 2004

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 60 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria

Patients may be eligible for this study if they:

Are HIV-negative.
Are between the ages of 18 and 60.
Agree not to become pregnant or to impregnate and to use an acceptable form of contraception while receiving study drugs and for 1 month after stopping study drugs. Patients who are not of reproductive potential are eligible without the contraception requirement.
Are within 30 percent of ideal body weight.
Weigh at least 110 lbs.

Exclusion Criteria

Patients may not be eligible for this study if they:

Have a history of any illness that requires current medical therapy.
Have a history of any kidney disorder.
Have any medical condition that, in the opinion of the investigator, would interfere with the study.
Are pregnant or breast-feeding.
Use certain drugs within 14 days prior to study entry.
Are allergic or sensitive to study drugs.
Use drugs or alcohol in a way which, in the opinion of the investigator, would interfere with the study.
Have any abnormality on electrocardiogram within 21 days prior to study entry.
Participate in any investigational drug studies within 21 days prior to study entry and during study.
Are unable to participate in pharmacokinetic visits.
Are unable to understand or follow the fluid intake requirement during the periods of IDV/RTV administration.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Univ of California San Francisco	San Francisco	California	United States	94110
2	Stanford Univ Med Ctr	Stanford	California	United States	943055107
3	Univ of Colorado Health Sciences Ctr	Denver	Colorado	United States	80262
4	Johns Hopkins Hosp	Baltimore	Maryland	United States	21287
5	Univ of Minnesota	Minneapolis	Minnesota	United States	55455
6	Washington Univ (St. Louis)	Saint Louis	Missouri	United States	63108
7	Cornell Univ Med Ctr	New York	New York	United States	10021
8	Univ of Rochester Medical Center	Rochester	New York	United States	14642
9	Univ of Cincinnati	Cincinnati	Ohio	United States	452670405