Double Protease Inhibitor to Darunavir Switch Study

Sponsor

St Stephens Aids Trust (Other)

Overall Status

Completed

CT.gov ID

NCT00531557

Collaborator

(none)

Enrollment

Location

Arm

Duration (Months)

0.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the study is to study the effects of switching from an antiretroviral combination that includes two ritonavir boosted protease inhibitors to replacement of these two protease inhibitors with a new protease inhibitor called Darunavir (also boosted with ritonavir).

The study will investigate the effect of the switch on viral load (the levels of the HIV virus in the blood), on immunological parameters (CD4 count) and on other safety parameters and also on quality of life.

In a subgroup of patients the impact of the switch on the body's response to the hormone insulin will also be measured (Euglycaemic clamp sub group)

Condition or Disease	Intervention/Treatment	Phase
HIV Infections	Drug: Darunavir ritonavir	Phase 4

Detailed Description

HIV-RNA and CD4+ cell count to monitor virological and immunological response on switching to DRV/r.

Routine safety bloods to include haematology and biochemistry (including U&E, fasted glucose and insulin, liver function test, fasting cholesterol and triglycerides and serum lactate measurements).

Quality of life EuroQOL questionnaires at baseline, and throughout the study to evaluate quality of life in the continued treatment/ treatment switch arms.

A sub group of 10 patients will undergo two euglycaemic clamp procedures in order to determine the extent of glucose disposal. The first clamp will be performed prior to the switching from a double boosted PI therapy to DRV/r and the second one following administration of DRV/r for 4 weeks.

Study Design

Study Type:

Interventional

Actual Enrollment :

12 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Official Title:

Phase IV Cohort Study Assessing Feasibility of Substituting Double Ritonavir-boosted Protease Inhibitors With Ritonavir-boosted Darunavir in HIV-infected Individuals With Viral Suppression on Highly Active Antiretroviral Therapy.

Study Start Date :

Sep 1, 2007

Actual Primary Completion Date :

Nov 1, 2008

Actual Study Completion Date :

Nov 1, 2008

Arms and Interventions

Arm	Intervention/Treatment
Other: 1 Darunavir 600mg BID with ritonavir 100mg BID administered orally.	Drug: Darunavir ritonavir

Arm

Intervention/Treatment

Other: 1

Darunavir 600mg BID with ritonavir 100mg BID administered orally.

Drug: Darunavir ritonavir

Outcome Measures

Primary Outcome Measures

The proportion of subjects maintaining viral suppression (< 50 copies/mL) [48 weeks]

Secondary Outcome Measures

• CD4+ count at screening, baseline, weeks 4, 12, 24, 36 and at the end of the study period • Viral suppression below 50 copies/mL and below 500 copies/mL at 4, 12, 24, 36 and 48 weeks • Laboratory abnormalities and adverse events at baseline, 4 [48 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

HIV-1 infected as documented by a licensed HIV-1 antibody ELISA test
At least 18 years of age
Currently on an antiretroviral regimen including a ritonavir boosted double protease inhibitor
The subject is virologically suppressed with a viral load < 50 copies/mL for three months or longer
The subject has a CD4+ count above 100 cells/mL
≤ Three DRV associated mutations on previous genotypic resistance test -or if no resistance test available, likely to have ≤ four protease inhibitor mutations based on their clinical history
If the subject is a woman of child bearing potential, she must agree to use a barrier method of contraception
The ability to understand and sign a written informed consent form, prior to participation in any screening procedures and must be willing to comply with all study requirements

Exclusion Criteria:

Pregnant or lactating women
Individuals with prior darunavir exposure
Previous allergic or hypersensitivity reaction to darunavir
Clinical or laboratory evidence of significantly decreased hepatic function or decompensation, irrespective of liver enzyme levels (liver insufficiency)
Subjects diagnosed with acute viral hepatitis at screening
Subjects with a grade 3 or 4 laboratory abnormality as defined by DAIDS grading table (see appendix 3: DAIDS AE grading Table), with the following exceptions unless clinical assessment foresees an immediate health risk to the subject:

Subjects with pre-existing diabetes or with asymptomatic glucose grade 3 or 4 elevations
Subjects with asymptomatic triglyceride or cholesterol elevations of grade 3 or

Presence of any currently active AIDS defining illness (Category C conditions according to the CDC Classification System for HIV Infection 1993) with the following exceptions: Stable cutaneous Kaposi's Sarcoma (i.e., no internal organ involvement other than oral lesions) that is unlikely to require any form of systemic therapy during the study; Wasting syndrome due to HIV infection.

Note: An AIDS defining illness that is not clinically stabilized for at least 30 days will be considered as currently active.

Active drug abuse, including alcohol or recreational drugs, which, in the opinion of the investigator, is expected to interfere with the subject's ability to adhere to the study procedures and treatment regimen. Subjects on a methadone program will be accepted if deemed appropriate by the investigator.