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Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

Sponsor
University of Southern California (Other)
Overall Status
Completed
CT.gov ID
NCT00002052
Collaborator
(none)
1
Location

Study Details

Study Description

Brief Summary

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

Condition or Disease Intervention/Treatment Phase
  • Drug: Ceftriaxone sodium
  • Drug: Ampicillin sodium
  • Drug: Amoxicillin trihydrate
 N/A

Study Design

Study Type:
Interventional
Primary Purpose:
Treatment
Official Title:
Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 0 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No

    Exclusion Criteria

    Co-existing Condition:
    Patients with the following are excluded:

    • Type I hypersensitivity to beta-lactam antibiotics.

    • Not expected to survive 12 weeks.

    • In a coma or with other central nervous system (CNS) impairment.

    Patients with the following are excluded:

    • Type I hypersensitivity to beta-lactam antibiotics.

    • Not expected to survive 12 weeks.

    • In a coma or with other central nervous system (CNS) impairment.

    Prior Medication:
    Excluded within 48 hours of study entry:
    • Treatment with an antibiotic active in vitro against Salmonella.

    HIV infection, AIDS, or AIDS related complex (ARC).

    • Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Los Angeles County - USC Med Ctr Los Angeles California United States 90033

    Sponsors and Collaborators

    • University of Southern California

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00002052
    Other Study ID Numbers:
    • 019A
    First Posted:
    Aug 31, 2001
    Last Update Posted:
    Jun 24, 2005
    Last Verified:
    Aug 1, 1989
    Keywords provided by , ,
    Salmonella Infections
    AIDS-Related Opportunistic Infections
    Acquired Immunodeficiency Syndrome
    Amoxicillin
    Ceftriaxone
    Additional relevant MeSH terms:
    Infections
    Communicable Diseases
    Salmonella Infections
    Amoxicillin
    Ceftriaxone
    Ampicillin

    Study Results

    No Results Posted as of Jun 24, 2005