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HLA Matching - Unrelated Umbilical Cord Blood Transplantation

Sponsor
Ann & Robert H Lurie Children's Hospital of Chicago (Other)
Overall Status
Completed
CT.gov ID
NCT00179946
Collaborator
(none)
30
Enrollment
1
Location
34
Duration (Months)
0.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

Condition or Disease Intervention/Treatment Phase
  • Procedure: HLA typing

Detailed Description

The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

  1. Is HLA matching beneficial to unrelated UCB transplantation?

  2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?

  3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?

  4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

Study Design

Study Type:
Observational
Anticipated Enrollment :
30 participants
Time Perspective:
Prospective
Official Title:
Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.
Study Start Date :
Jun 1, 2003
Actual Primary Completion Date :
Apr 1, 2006
Actual Study Completion Date :
Apr 1, 2006

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.
    Exclusion Criteria:
    • Refusal to participate in study.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Ann & Robert H Lurie Children's Hospital of Chicago Chicago Illinois United States 60611

    Sponsors and Collaborators

    • Ann & Robert H Lurie Children's Hospital of Chicago

    Investigators

    • Principal Investigator: Sonali Chadhury, MD, Ann & Robert H Lurie Children's Hospital of Chicago

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00179946
    Other Study ID Numbers:
    • BMT 0603 HLA
    First Posted:
    Sep 16, 2005
    Last Update Posted:
    Jul 30, 2018
    Last Verified:
    Jul 1, 2018
    Additional relevant MeSH terms:
    Hematologic Diseases

    Study Results

    No Results Posted as of Jul 30, 2018