Home Air Quality Impact for Adults With Asthma

Sponsor

University of Kansas Medical Center (Other)

Overall Status

Recruiting

CT.gov ID

NCT05224076

Collaborator

National Institute of Environmental Health Sciences (NIEHS) (NIH)

Enrollment

Location

18.1

Anticipated Duration (Months)

2.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.

Condition or Disease	Intervention/Treatment	Phase
Asthma Environmental Exposure Home Environment Related Disease	Other: Home Air Quality

Detailed Description

The aims of this feasibility study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds [VOCs], particulates [PM2.5]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and forced expiratory volume percent predicted, respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants' will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility.

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

The Changing COVID-19 Landscape: A Feasibility Study to Capture Momentary Residential Environmental Exposures and Asthma Symptoms in Adults

Actual Study Start Date :

Mar 30, 2022

Anticipated Primary Completion Date :

Mar 1, 2023

Anticipated Study Completion Date :

Oct 1, 2023

Outcome Measures

Primary Outcome Measures

Home environmental exposure to Volatile organic compounds [Measured continuously for 14 days]
Degree of home exposures to volatile organic compounds as measured by the Awair home air quality monitor
Home environmental exposure to particulate matter (PM) [Measured continuously for 14 days]
Degree of home exposures to PM2.5 as measured by the Awair home air quality monitor
Asthma control [Assessed daily for 14 days]
Forced Expiratory Volume (FEV) Percent predicted as measured by ZEPHYRx home spirometer

Secondary Outcome Measures

Usability of study tools [14 days]
Adapted System Usability Scale, 30 items assessing usability of the ZEPHYRx home spirometer, Awair home air quality monitor, and the EMA - with response options of 1= Strongly agree to 5=Strongly Disagree
Compliance with Ecological Momentary Assessment (EMA) prompts [Compliance over 4-hour periods for 14 days]
Frequency of responses to daily scheduled, random, and air quality triggered EMA prompts

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Adults who previously participated in the online Global Covid-19 and Asthma Study, indicated willingness to be contacted for future research, and reported high use of disinfectant/cleaning products since COVID-19 (≥5 per week).
Current Asthma Control Test (ACT) ≤19
Own a smartphone
Have a Wi-Fi/wireless internet connection in their home.