In-hospital Cardiac Arrest - Dynamics and State Transitions

• Sponsor: St. Olavs Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT00920244
• Collaborator: Norwegian Air Ambulance Foundation (Other), Norwegian University of Science and Technology (Other)
• Enrollment: 285
• Location: 1
• Duration (Months): 68
• Patients Per Site Per Month: 4.2

Study Details

Study Description

Brief Summary

The purpose of this study is to analyse transitions in cardiac rhythm and hemodynamic variables during resuscitation of patients with in-hospital cardiac arrest.

Condition or Disease	Intervention/Treatment	Phase
Heart Arrest; Death, Sudden, Cardiac	Procedure: Cardiopulmonary resuscitation (CPR); Drug: Epinephrine; Drug: Atropine; Drug: Amiodarone; Device: External defibrillator

Detailed Description

In-hospital cardiac arrest carries a grave prognosis, with survival to discharge in the range of 15-20%. Key factors determining outcome include the presenting cardiac rhythm, aetiology, and early initiation of resuscitation. Some cardiac rhythms benefit from defibrillation (shockable rhythms). During resuscitation patients may switch between shockable and non-shockable rhythms, and may show signs of spontaneous circulation temporarily. Depending on rhythm and according to guidelines, patients receive direct current (DC) shocks (defibrillator) and/or i.v. adrenaline, atropine and amiodarone, which may affect state-transitions. We wish to make statistical analysis (time-series analysis, Markov modelling) of these state-transitions and variations in hemodynamic variables during resuscitation, related to CPR interventions and the cause of arrest. The cause of arrest will be determined based on chart records, interview with staff and autopsy if appropriate. One hypothesis is that differences in the patterns of state-transitions may reflect underlying aetiology, which may guide in future decision-making during resuscitation.

Study Design

• Study Type: Observational
• Actual Enrollment: 285 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Official Title: Dynamics and State Transitions During Resuscitation in In-hospital Cardiac Arrest
• Study Start Date: Aug 1, 2009
• Actual Primary Completion Date: Apr 1, 2015
• Actual Study Completion Date: Apr 1, 2015

Outcome Measures

Primary Outcome Measures

1. Survival to discharge [1 year]

Secondary Outcome Measures

1. Short-term survival [minutes-days]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients with in-hospital cardiac arrest who are resuscitated

Exclusion Criteria:

• Younger than 18 years old

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	St.Olavs Hospital, Department of Anesthesia	Trondheim		Norway	7014

Sponsors and Collaborators

• St. Olavs Hospital
• Norwegian Air Ambulance Foundation
• Norwegian University of Science and Technology

Investigators

• Study Chair: Eirik Skogvoll, MD, PhD, St. Olavs Hospital
• Principal Investigator: Trond Nordseth, MD, St. Olavs Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: St. Olavs Hospital
• ClinicalTrials.gov Identifier: NCT00920244
• Other Study ID Numbers: 4.2008.2402 (REK); 08/11457; 20708/2/IB
• First Posted: Jun 15, 2009
• Last Update Posted: Sep 5, 2018
• Last Verified: Aug 1, 2018

• Keywords provided by St. Olavs Hospital: Resuscitation; Cardiac arrest; State-transitions; Markov
• Additional relevant MeSH terms: Heart Arrest; Death, Sudden, Cardiac; Death, Sudden; Atropine; Amiodarone; Epinephrine

Study Results

No Results Posted as of Sep 5, 2018