To Study the Effects of Host Genetic Factors on Liver Cirrhosis
Sponsor
Asfendiyarov Kazakh National Medical University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05095181
Collaborator
(none)
1,000
13.9
Study Details
Study Description
Brief Summary
The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis .
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Anticipated Enrollment
:
1000 participants
Observational Model:
Other
Time Perspective:
Prospective
Official Title:
Preventive and Personalized Medicine (2021-2023)
Anticipated Study Start Date
:
Oct 23, 2021
Anticipated Primary Completion Date
:
Dec 20, 2021
Anticipated Study Completion Date
:
Dec 20, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental group: patients with liver cirrhosis |
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
|
| Control group patients without liver cirrhosis |
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
|
Outcome Measures
Primary Outcome Measures
- genotyping for the SNP associated with liver cirrhosis [1 year]
Genotype frequency of SNP in the study genes of participants and control participants.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 60 Years
Sexes Eligible for Study:
All
Inclusion Criteria:
- hepatitis B
Exclusion Criteria:
- the casual aget of liver disease is not viral infection, such as alcohol abuse
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Asfendiyarov Kazakh National Medical University
Investigators
- Principal Investigator: Bibigul Saparbekovna, PhD, JSC "National Scientific Center of Surgery named after A.N. Syzganova "
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Ildar Fakhradiyev,
Head of the Laboratory of Experimental Medicine,
Asfendiyarov Kazakh National Medical University
ClinicalTrials.gov Identifier:
NCT05095181
Other Study ID Numbers:
- 1188
First Posted:
Oct 27, 2021
Last Update Posted:
Oct 27, 2021
Last Verified:
Oct 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Ildar Fakhradiyev,
Head of the Laboratory of Experimental Medicine,
Asfendiyarov Kazakh National Medical University
Additional relevant MeSH terms: