A Cohort Study of Hyperthermia and Imiquimod for the Treatment of Flat Warts
Study Details
Study Description
Brief Summary
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of warts is often difficult and involves different destructive procedures.Although several pharmacological and physical topical treatments are available (keratolytic agents, electrosurgery, cryotherapy, carbon dioxide laser), results are often unsatisfactory in terms of efficacy (frequent recurrence) and cosmetic outcome (scars, inflammatory reactions, transient or permanent hyper- or hypopigmentation).
Mild local Hyperthermia with a certain temperature range has been successfully used in the treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared HPV in more than half of the patients with plantar warts. Investigators also note the fact that in patients with multiple lesions, the clearance of the target lesion is commonly followed by clearance of other distant lesions, a phenomenon suggesting that local hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the purpose of the study is to evaluation local hyperthermia in the treatment of flat warts Appropriate control arms were designed for different conditions.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Local Hyperthermia at 44℃ for falt warts Local hyperthermia at 44℃ for 30 mins on one lesion region, at days of 1,2,3, 15, 16, 21 and 28. |
Device: Local Hyperthermia at 44℃
As an experimental arm, for patients with flat warts
|
| Active Comparator: Imiquimod for Flat Warts Miquimod treatment: 3 times a week for 1 month |
Drug: Imiquimod treatment
As an control arm, for patients with flat warts
|
Outcome Measures
Primary Outcome Measures
- clearance rates of HPV [3 months after the last time of treatment]
to evaluate the clearance rates of all lesions in different treatment groups 3 month after treatment.
Secondary Outcome Measures
- effective rates of HPV [3 months after the last time of treatment]
to evaluate the effective rates of all lesions in different treatment groups 3 month after treatment.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
12-65 years old;
-
diagnosis confirmed;
-
signed informed consent
Exclusion Criteria:
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Pregnant woman;
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Local or systematic treatment within 3 months;
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Comorbidity of other severe gynecological inflammation,
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Infection, or tumor;
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Comorbidity of other serious illnesses;
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No guarantee of timely treatment and follow-up
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | the First Hospital of China Medical University | Shenyang | China | 110001 |
Sponsors and Collaborators
- First Hospital of China Medical University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HH20190606