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GEP: Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Sponsor
Stanford University (Other)
Overall Status
Completed
CT.gov ID
NCT01451476
Collaborator
(none)
122
Enrollment
1
Location
67
Duration (Months)
1.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    122 participants
    Observational Model:
    Other
    Time Perspective:
    Cross-Sectional
    Official Title:
    Human Skin Aging: Clinical Parameters and Gene Expression Profiling
    Study Start Date :
    May 1, 2010
    Actual Primary Completion Date :
    Apr 1, 2015
    Actual Study Completion Date :
    Dec 1, 2015

    Arms and Interventions

    Arm Intervention/Treatment
    Healthy females aged >=18

    Healthy female volunteers of skin type I or II

    Outcome Measures

    Primary Outcome Measures

    1. Assessment of age related gene expression changes in skin [Cross sectional]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • healthy female, age 18 or older,

    • Fitzpatrick type 1 or 2 skin,

    • able to read and understand written consent form,

    • body mass index normal or overweight range,

    • willing to take blood tests and donate skin samples

    Exclusion Criteria:

    • pregnant or lactating,

    • history of cosmetic surgery affecting the face,

    • use of prescription anti-aging medications for 2 weeks prior to study,

    • use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,

    • medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Stanford Dermatology Redwood City California United States 94603

    Sponsors and Collaborators

    • Stanford University

    Investigators

    • Principal Investigator: Alfred Lane, MD, Stanford University
    • Study Director: Anne Chang, MD, Stanford University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Anne Chang, instructor, Stanford University
    ClinicalTrials.gov Identifier:
    NCT01451476
    Other Study ID Numbers:
    • HSA_GEP
    • 003
    First Posted:
    Oct 13, 2011
    Last Update Posted:
    Jan 22, 2020
    Last Verified:
    Jan 1, 2020
    Keywords provided by Anne Chang, instructor, Stanford University
    Ageing

    Study Results

    No Results Posted as of Jan 22, 2020