FISCIP: Functional Imaging of Social Cognition in Premanifest Huntington's Disease

Sponsor

Universitaire Ziekenhuizen Leuven (Other)

Overall Status

Unknown status

CT.gov ID

NCT02551705

Collaborator

(none)

Enrollment

Arms

Duration (Months)

Study Details

Study Description

Brief Summary

Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures. The symptoms of HD include involuntary movements, cognitive deterioration and behavioural disturbances. It has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (preHD). This deficit in perception of emotions has been primarily investigated by means of facial expressions. However, emotions can also be expressed through body language. Here, the investigators propose to investigate whether the emotion comprehension deficit in preHD also includes body language comprehension.

Condition or Disease	Intervention/Treatment	Phase
Huntington's Disease	Other: functional Imaging	N/A

Detailed Description

The investigators will perform a detailed evaluation of body language comprehension abilities in persons that carry the genetic mutation causing HD, but who do not show any movement symptoms yet. In addition, the associated changes in brain structure and function will be studied. The aim is to perform the study with the same group of participants who participated in a recent study carried on by this research group, in which the functional brain changes associated with increased irritability were investigated. This will allow to relate emotion experience with emotion perception. The results of the study may provide a target to further develop therapeutic interventions and aid caregivers of preHD subjects.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

40 participants

Allocation:

Non-Randomized

Intervention Model:

Crossover Assignment

Masking:

Single (Investigator)

Primary Purpose:

Basic Science

Official Title:

Functional Imaging of Social Cognition in Premanifest Huntington's Disease

Study Start Date :

Oct 1, 2015

Anticipated Primary Completion Date :

Oct 1, 2017

Anticipated Study Completion Date :

Oct 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: functional Imaging mutation carrier Premanifest mutation carrier, behavioral and neural emotional memory processing	Other: functional Imaging Brain responses associated with emotional memory will be investigated
Active Comparator: functional Imaging non-carrier non-carrier family member, behavioral and neural emotional memory processing	Other: functional Imaging Brain responses associated with emotional memory will be investigated

Arm

Intervention/Treatment

Experimental: functional Imaging mutation carrier

Premanifest mutation carrier, behavioral and neural emotional memory processing

Other: functional Imaging

Brain responses associated with emotional memory will be investigated

Active Comparator: functional Imaging non-carrier

non-carrier family member, behavioral and neural emotional memory processing

Other: functional Imaging

Brain responses associated with emotional memory will be investigated

Outcome Measures

Primary Outcome Measures

Significant group differences in brain activation for perceiving emotional vs neutral faces by following random effects analyses [6 months]
Significant group differences in beta-values for the contrast emotional faces vs neutral faces following general linear model parameter estimates

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 90 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Huntington's disease positive genotype and non-carrier siblings

Exclusion Criteria:

visible chorea
MRI contra-indications
major neurological/psychiatric comorbidity

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Universitaire Ziekenhuizen Leuven

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Jan Van den Stock, Post-doctoral researcher, Universitaire Ziekenhuizen Leuven

ClinicalTrials.gov Identifier:

NCT02551705

Other Study ID Numbers:

S58457

First Posted:

Sep 16, 2015

Last Update Posted:

Sep 16, 2015

Last Verified:

Sep 1, 2015

Additional relevant MeSH terms:

Huntington Disease

Study Results

No Results Posted as of Sep 16, 2015