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Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

Sponsor
North Carolina State University (Other)
Overall Status
Completed
CT.gov ID
NCT05119153
Collaborator
(none)
19
Enrollment
1
Location
4
Arms
23.9
Actual Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.

Condition or Disease Intervention/Treatment Phase
  • Dietary Supplement: Placebo Comparator
  • Dietary Supplement: Light Roasted Coffee
  • Dietary Supplement: Medium Roasted Coffee
  • Dietary Supplement: Dark Roasted Coffee
 N/A

Detailed Description

This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts.

In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose.

In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose.

In each part, fasting and postprandial glucose profiles were determined.

Study Design

Study Type:
Interventional
Actual Enrollment :
19 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Intervention Model Description:
Randomized, single-blinded, partial block, crossover designRandomized, single-blinded, partial block, crossover design
Masking:
Single (Participant)
Masking Description:
Subjects provided placebo and coffee beverages in a color coded bottles
Primary Purpose:
Basic Science
Official Title:
Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans
Actual Study Start Date :
Nov 5, 2019
Actual Primary Completion Date :
Dec 20, 2020
Actual Study Completion Date :
Oct 31, 2021

Arms and Interventions

Arm Intervention/Treatment
Placebo Comparator: Placebo Comparator

Placebo composed of water and caramel color.

Dietary Supplement: Placebo Comparator
Placebo designed to mimic coffee color.
Experimental: Light Roasted Coffee

12 oz light roast coffee beverage prepared at 55 g ground coffee/L water

Dietary Supplement: Light Roasted Coffee
12 oz light roast coffee
Experimental: Medium Roasted Coffee

12 oz medium roast coffee beverage prepared at 55 g ground coffee/L water

Dietary Supplement: Medium Roasted Coffee
12 oz medium roast coffee
Experimental: Dark Roasted Coffee

12 oz dark roast coffee beverage prepared at 55 g ground coffee/L water

Dietary Supplement: Dark Roasted Coffee
12 oz dark roast coffee

Outcome Measures

Primary Outcome Measures

  1. Changes in Blood Glucose [6 weeks]

    Each week, fasted baseline and postprandial measurements taken out to 240 minutes

Secondary Outcome Measures

  1. Changes in Glucose Area Under the Curve [6 weeks]

    Used glucose changes over 240 minutes to construct area under the curve

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

• Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.

Exclusion Criteria:

  • Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.

  • Weight less than 110 pounds (55 kg)

  • Pre-existing health conditions, such as:

  • High cholesterol

  • Hypertension

  • Cardiovascular disease

  • Gastrointestinal motility disorders

  • Hypo- or hyperthyroidism

  • Anemia

  • Renal disease

  • Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease

  • Chronic or acute pancreatitis

  • Diabetes type 1 or 2

  • Insulin resistance

  • Polycystic ovary syndrome

  • Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals.

  • Currently taking prescription medication

  • Current smoker

  • Consumes more than 3 alcoholic beverages per day

  • Pregnant or breastfeeding

  • Not willing to take their own blood samples with finger sticks

Contacts and Locations

Locations

Site City State Country Postal Code
1 Schaub Hall, Campus Box 7624 Raleigh North Carolina United States 27695

Sponsors and Collaborators

  • North Carolina State University

Investigators

  • Principal Investigator: Gabriel K Harris, PhD, North Carolina State University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Gabriel Keith Harris, Associate Professor of Food Science, North Carolina State University
ClinicalTrials.gov Identifier:
NCT05119153
Other Study ID Numbers:
  • 16857
First Posted:
Nov 12, 2021
Last Update Posted:
Nov 12, 2021
Last Verified:
Nov 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Gabriel Keith Harris, Associate Professor of Food Science, North Carolina State University
coffee
glucose challenge
blood glucose levels
Additional relevant MeSH terms:
Hyperglycemia

Study Results

No Results Posted as of Nov 12, 2021