Exercise and Vascular Function in Postmenopausal Females With Hypertension
Study Details
Study Description
Brief Summary
The treatment of high blood pressure, or hypertension, is multifaceted and can include pharmacological therapies (i.e., medications) and lifestyle modifications such as physical activity. Chronotherapy, which describes timing of a treatment with your body's daily rhythms, has recently been used with hypertension medications and has been shown to be effective at lowering blood pressure and reducing the risk of cardiovascular disease events. Specifically, taking medications in the evening was shown to be more effective than morning medication routines. Little information is available about the effectiveness of chronotherapy combined with exercise (i.e., planned physical activity) interventions in older adults with hypertension. The purpose of this study is to examine how exercise performed in the morning and early evening affects blood pressure and other measures of blood vessel health in postmenopausal females with hypertension.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Blood pressure has an internal rhythm associated with the 24-hr clock. Nocturnal blood pressure (BP) is a key contributor to cardiovascular health and may be improved by exercise. Moreover, the time of day of the exercise may be a key factor. This study aims to evaluate the effect of evening exercise on BP and other measures of vascular function in older females with hypertension.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Morning-AM Before 10AM |
Behavioral: Exercise
walking and handgrip exercise
Behavioral: Control
seated rest
|
| Experimental: Evening-PM After 4PM |
Behavioral: Exercise
walking and handgrip exercise
Behavioral: Control
seated rest
|
Outcome Measures
Primary Outcome Measures
- Nocturnal systolic BP [24 hours]
Reduction in systolic nocturnal BP (exercise-control)
Secondary Outcome Measures
- Early post-exercise hypotension [30 minutes]
Post-exercise systolic BP (exercise - control)
- Endothelial function [24 hours]
Flow mediated dilation of the brachial artery
- Microvascular function [24 hours]
Rapid onset vasodilation of the popliteal artery
Other Outcome Measures
- Ambulatory blood pressure [24 hours]
Systolic and diastolic BPs over a 24-hr period
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Systolic BP equal to or greater than 130 mmHg and diastolic BP equal to and greater than 80 mmHg
-
55-80 years old
-
Post-menopausal female
-
Early or intermediate chronotype
-
Able to walk without assistance
Exclusion Criteria:
-
Habitually physically active defined as 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week
-
Overt pulmonary disease/condition as follows: chronic bronchitis, chronic obstructive pulmonary disease, emphysema, or pulmonary hypertension
-
Cardiometabolic disease/condition as follows: diabetes, heart failure, peripheral arterial disease, stroke, coronary artery disease, renal disease, secondary hypertension, chronic venous insufficiency or deep vein thrombosis within last 6 months
-
Cancer within last 5 years
-
Body mass index >39 kg/m2
-
Current smoking or vaping
-
Evening shift work
-
Evening chronotype
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Michigan State University | East Lansing | Michigan | United States | 48824 |
Sponsors and Collaborators
- Michigan State University
- National Heart, Lung, and Blood Institute (NHLBI)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- R56HL164575-Study1
- R56HL164575-01