The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Study Details
Study Description
Brief Summary
Hypertensive disorders of pregnancy, include pre-existing and gestational hypertension, preeclampsia, and eclampsia, it complicates up to 10% of pregnancies and represents a significant cause of maternal and perinatal morbidity and mortality. Following the "National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy" recommendation is currently a systolic blood pressure (SBP) ⩾ of 140 mmHg and diastolic blood pressure (DBP) ⩾ of 90 mmHg. The diagnosis generally requires two separate measurements.
Accepted across international guidelines are the following four categories:
Chronic/pre-existing hypertension (Hypertension discovered preconception or prior to 20 weeks gestation), Gestational hypertension (Hypertension that appears de novo after 20 weeks gestation and normalizes after pregnancy), Preeclampsia-eclampsia (De novo hypertension after 20 weeks' gestation accompanied by proteinuria, other features of maternal organ dysfunction or uteroplacental dysfunction), Chronic/pre-existing hypertension with superimposed preeclampsia-eclampsia. Over the past 2 decades, extensive epidemiologic studies have clearly established that obesity is a major risk for gestational hypertension and preeclampsia. The risk of preeclampsia typically doubles with each 5-7 kg/m2 increase in pre-pregnancy. The mechanisms have only been partially explored; increased cytokine-mediated inflammation and oxidative stress, increased shear stress, dyslipidemia, and increased sympathetic activity1 have all been proposed as possible pathways. Few studies have examined the relationship between pre-pregnancy BMI, gestational weight gain (GWG), and the risk of preeclampsia. So, our study aims to evaluate the adverse maternal and fetal outcomes related to hypertension in obese and non-obese pregnant women.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Other: Non-obese hypertensive pregnant women
|
Drug: Anti-Hypertensive
For control of the blood pressure
Radiation: Ultrasound
For assessment of gestational age and fetal weight
Radiation: Doppler ultrasound
Umbilical artery Doppler assessment
Diagnostic Test: complete blood count
For assessment of platelet count
Diagnostic Test: Body mass index
for assessment of maternal weight during pregnancy
|
| Other: Obese hypertensive pregnant women
|
Drug: Anti-Hypertensive
For control of the blood pressure
Radiation: Ultrasound
For assessment of gestational age and fetal weight
Radiation: Doppler ultrasound
Umbilical artery Doppler assessment
Diagnostic Test: complete blood count
For assessment of platelet count
Diagnostic Test: Body mass index
for assessment of maternal weight during pregnancy
|
Outcome Measures
Primary Outcome Measures
- The rate of adverse maternal outcome related to hypertension in both groups [3 month]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Women aged from 20-35 years.
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Pregnant women from 28-30 weeks.
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Pregnant women with a singleton pregnancy.
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Women with chronic or gestational hypertension.
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Women with normal baseline investigations (uncomplicated hypertension).
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Obese women and non-obese women.
Exclusion Criteria:
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Women with preeclampsia/eclampsia.
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Women need urgent termination of pregnancy.
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Women with co-morbidities such as diabetes, renal diseases, cardiac ...etc.
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Women with confirmed fetal malformation.
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Women who will refuse to participate.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Women Health Hospital - Assiut university | Assiut | Egypt | 71111 |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HT-pre