Hypertension Screening and Treatment Program

Sponsor

US Department of Veterans Affairs (U.S. Fed)

Overall Status

Completed

CT.gov ID

NCT00007592

Collaborator

(none)

Locations

Study Details

Study Description

Brief Summary

Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.

Condition or Disease	Intervention/Treatment	Phase
Hypertension	Drug: Chlorthalidone Drug: Furosemide

Detailed Description

Primary Hypothesis: A variety of clinical questions of major importance can be addressed using clinical data routinely obtained in the VA Hypertension Screening and Treatment Program. For example, treatment of mild hypertension reduces the risk of strokes and heart attacks.

Secondary Hypothesis: Target organ damage occurs despite blood pressure control.

Intervention: Chlorthalidone, furosemide, hydrochlorothiazide, metolazone, indapamide, amiloride, spironolactone, triamterene, atenolol, metoprolol, nadolol, pindolol, propranolol, timolol, acebutolol, penbutolol, clonidine, guanethidine, methydopa, prazosin, guanadrel, labetalol, reserpine, guanfacine, hydralazine, minoxidil, captopril, enalapril, lisinopril, diltiazem, nifedipine, verapamil, nicardipine, dyazide, maxzide, pargyline, terazosin, other anti-hypertensives.

Primary Outcomes: Blood Pressure and Target Organ Damage

Study Abstract: Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.

This demonstration project provides for central collection of a standard set of clinical data for patients at some of the Hypertension Screening and Treatment Program clinics, thereby setting up a national data base on the treatment of hypertension. The primary objective of this project is to demonstrate the value of establishing this type of database. The database is being used to estimate the average annual cost of different antihypertensive regimens, to determine the cost-efficacy of different therapies and the least expensive effective therapy and to address some major unanswered clinical questions that require large populations and long-term patient care data. There are currently 13 medical centers participating.

Study Design

Study Type:

Observational

Time Perspective:

Prospective

Official Title:

VA HYPERTENSION SCREENING AND TREATMENT PROGRAM (PILOT STUDY)

Study Start Date :

Jun 1, 1989

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Patients at Hypertension Screening and Treatment Program clinics

Contacts and Locations

Locations

	Site	City	State	Country
1	Vamc - Sepulveda	Sepulveda	California	United States
2	Vamc - Washington, Dc	Washington	District of Columbia	United States
3	Vamc - Miami	Miami	Florida	United States
4	Vamc - Indianapolis	Indianapolis	Indiana	United States
5	Vamc - Iowa City	Iowa City	Iowa	United States
6	Vamc - Jackson	Jackson	Mississippi	United States
7	Vamc - Dayton	Dayton	Ohio	United States
8	Vamc - Philadelphia	Philadelphia	Pennsylvania	United States
9	Vamc - Pittsburgh	Pittsburgh	Pennsylvania	United States
10	Vamc - Memphis	Memphis	Tennessee	United States
11	Vamc - Richmond	Richmond	Virginia	United States
12	Vamc - San Juan, Pr	San Juan		Puerto Rico