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Free Fatty Acids: Short Exposure Study

Sponsor
Purdue University (Other)
Overall Status
Completed
CT.gov ID
NCT01686113
Collaborator
(none)
100
Enrollment
1
Location
2
Arms
24
Duration (Months)
4.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.

Condition or Disease Intervention/Treatment Phase
  • Other: NEFA
  • Other: Sucrose
 N/A

Detailed Description

The possibility that humans can taste non-esterified fatty acids (NEFA) - so-called fat taste

  • is a relatively new area of research. Previous work suggests that subjects require an average of between two and three testing sessions of approximately an hour each before they can reliably detect NEFA, and the average number of visits to get the lowest threshold is six. Streamlining this process is of great interest to researchers who wish to test many people as quickly as possible. Other taste qualities, including umami and sweet, have shown improvement in detection sensitivity in subjects that have undergone ten second exposures to these taste qualities for 10 days upon subsequent re-testing. We seek to determine if the same improvements can be seen with fat taste.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
100 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Participant)
Primary Purpose:
Basic Science
Official Title:
Free Fatty Acids: Short Exposure Study
Study Start Date :
May 1, 2012
Actual Primary Completion Date :
May 1, 2014
Actual Study Completion Date :
May 1, 2014

Arms and Interventions

Arm Intervention/Treatment
Experimental: NEFA

Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.

Other: NEFA
Other Names:
  • Oleic acid

    		•
    Active Comparator: Control

    Participants swish and spit 5 mL of sucrose solution everyday for 10 days.

    Other: Sucrose

    Outcome Measures

    Primary Outcome Measures

    1. NEFA detection threshold [10 days]

    Secondary Outcome Measures

    1. Hunger [2 days]

      Visual analog scale assessment of hunger level prior to testing

    2. BMI [1 day]

    3. Taste descriptor [10 days]

      Description of NEFA taste by participant, e.g., sour, bitter, etc.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 55 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • good health

    • available for multiple testing visits

    Exclusion Criteria:
    • have participated in a fat taste study in the past 6 months

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Purdue University West Lafayette Indiana United States 47907

    Sponsors and Collaborators

    • Purdue University

    Investigators

    • Principal Investigator: Richard D Mattes, PhD, Purdue University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Richard Mattes, Distinguished Prof Foods and Nutrition, Purdue University
    ClinicalTrials.gov Identifier:
    NCT01686113
    Other Study ID Numbers:
    • 1205012317
    First Posted:
    Sep 17, 2012
    Last Update Posted:
    Nov 21, 2014
    Last Verified:
    Nov 1, 2014
    Keywords provided by Richard Mattes, Distinguished Prof Foods and Nutrition, Purdue University
    Taste
    Fat Taste
    Threshold Testing
    Additional relevant MeSH terms:
    Ageusia

    Study Results

    No Results Posted as of Nov 21, 2014