Metabolic Changes in Hypothyroid Patients

Sponsor

University of Aarhus (Other)

Overall Status

Completed

CT.gov ID

NCT00524238

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

0.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Hypothyroidism is a frequent condition in danish women, but often overlooked. Along with fatigue one of the main symptoms is weight gain as a result to significantly decreased energy expenditure.

This study was undertaken to elucidate changes in glucose, lipid and amino acid turnover in these patients.

Condition or Disease	Intervention/Treatment	Phase
Hypothyroidism	Drug: L-thyroxine	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

22 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Impact of Hypothyroidism on Glucose, Lipid, and Amino Acid Turnover

Study Start Date :

Mar 1, 2004

Actual Primary Completion Date :

Aug 1, 2006

Actual Study Completion Date :

Aug 1, 2006

Arms and Interventions

Arm	Intervention/Treatment
Other: 1 11 hypothyroid patients, newly diagnosed, examined before and after treatment	Drug: L-thyroxine The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.
No Intervention: 2 10 healthy controls

Arm

Intervention/Treatment

Other: 1

11 hypothyroid patients, newly diagnosed, examined before and after treatment

Drug: L-thyroxine

The hypothyroid patients receive usual treatment with L-thyroxine in our out patient clinic. The doctors there subscribe the medication, this study has no protocol regarding this, we observe the patients again after having been biochemically euthyroid for at least two months.

No Intervention: 2

10 healthy controls

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Newly diagnosed hypothyroidism with tsh over 40 mU/L, etiology chronic autoimmune thyroiditis
Healthy controls matched regarding sex, age and body mass index