Colour Vision Impairment During Acute Hypobaric Hypoxia
Study Details
Study Description
Brief Summary
This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.
Five different Groups were analysed:
-
ground control binocular (n=12, Bi/GC)
-
ground control monocular (n=11, Mo/GC)
-
10,000 ft, 60 min, monocular (n=10, Mo/60/10,000)
-
15,000 ft, 15 min, binocular (n=11, Bi/15/15,000)
-
15,000 ft, 60 min, monocular (n=10, Mo/60/15,000)
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| No Intervention: ground control binocular Intervention: pressure chamber environment Procedures: Colour vision tests were performed under normoxia with both eyes three times in a row for appropriate comparability to the simulated flight stages pre-peri-post hypoxia in the intervention groups |
|
| No Intervention: ground control monocular Intervention: pressure chamber environment Procedures: Colour vision tests were performed under normoxia with one eye at a time three times in a row for appropriate comparability to the simulated flight stages pre-peri-post hypoxia in the intervention groups |
|
| Experimental: 10,000 ft, 60 min, monocular pre-peri-post Intervention: Hypoxia equivalent to an altitude of 10.000 ft. for 60 minutes Procedures: Colour vision tests were performed with one eye at a time, thereby: pre intervention with no hypoxia administered during intervention with hypoxia equivalent to an altitude of 10.000 ft. for 60 minutes post intervention with no hypoxia administered |
Other: Hypobaric Hypoxia
The Waggoner Computerized Color Vision Test (WCCVT) and the Waggoner D-15 (WC-D15) were performed by 54 healthy volunteers in a decompression chamber.
|
| Experimental: 15,000 ft, 15 min, binocular Intervention: Hypoxia equivalent to an altitude of 15.000 ft. for 15 minutes Procedures: Colour vision tests were performed with both eyes, thereby: pre intervention with no hypoxia administered during intervention with hypoxia equivalent to an altitude of 15000 ft. for 15 minutes post intervention with no hypoxia administered |
Other: Hypobaric Hypoxia
The Waggoner Computerized Color Vision Test (WCCVT) and the Waggoner D-15 (WC-D15) were performed by 54 healthy volunteers in a decompression chamber.
|
| Experimental: 15,000 ft, 60 min, monocular Intervention: Hypoxia equivalent to an altitude of 15.000 ft. for 60 minutes Procedures: Colour vision tests were performed with one eye at a time, thereby: pre intervention with no hypoxia administered during intervention with hypoxia equivalent to an altitude of 15.000 ft. for 60 minutes post intervention with no hypoxia administered |
Other: Hypobaric Hypoxia
The Waggoner Computerized Color Vision Test (WCCVT) and the Waggoner D-15 (WC-D15) were performed by 54 healthy volunteers in a decompression chamber.
|
Outcome Measures
Primary Outcome Measures
- Colour vision pre hypoxia monocular/binocular Waggoner CCVT [Assessment was conducted 15 minutes before the start of the hypoxia intervention and the number of correctly identified plates in the Waggoner CCVT was collected]
Waggoner CCVT was administered in the pressure chamber pre hypoxia intervention, thereby the following parameters were collected: - the number of correctly identified plates in the Waggoner CCVT as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: - depending on the time the subjects took for the colour vision tests, the time between the end of the pre-test and the onset of hypoxia was slightly variable
- Colour vision pre hypoxia monocular/binocular D15 [Assessment was conducted 15 minutes before the start of the hypoxia intervention and S-Index, C-Index and TES in the Waggoner D15 were collected]
Waggoner D15 was administered in the pressure chamber pre hypoxia intervention, thereby the following parameters were collected: - S-Index, C-Index and TES in the Waggoner D15 as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: depending on the time the subjects took for the colour vision tests, the time between the end of the pre-test and the onset of hypoxia was slightly variable
- Colour vision during hypoxia monocular/binocular Waggoner CCVT [Assessment was conducted immediately or 45 minutes after induction of hypoxia and the number of correctly identified plates in the Waggoner CCVT was collected]
Waggoner CCVT was administered in the pressure chamber during hypoxia intervention, thereby the following parameters were collected: - the number of correctly identified plates in the Waggoner CCVT as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: as of the study arm "15,000 ft, 15 min, binocular" assessment was conducted immediately after onset of hypoxia as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" assessment was conducted 45 minutes after onset of hypoxia depending on the time the subjects took for the colour vision tests, the time between the end of the peri-test and the end of hypoxia was slightly variable
- Colour vision during hypoxia monocular/binocular D15 [Assessment was conducted immediately or 45 minutes after induction of hypoxia and S-Index, C-Index and TES in the Waggoner D15 were collected]
Waggoner D15 was administered in the pressure chamber during hypoxia intervention, thereby the following parameters were collected: - S-Index, C-Index and TES in the Waggoner D15 as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: as of the study arm "15,000 ft, 15 min, binocular" assessment was conducted immediately after onset of hypoxia as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" assessment was conducted 45 minutes after onset of hypoxia depending on the time the subjects took for the colour vision tests, the time between the end of the peri-test and the end of hypoxia was slightly variable
- Colour vision after hypoxia monocular/binocular Waggoner CCVT [Assessment was conducted immediately after hypoxia and the number of correctly identified plates in the Waggoner CCVT was collected]
Waggoner CCVT was administered in the pressure chamber post hypoxia intervention, thereby the following parameters were collected: - the number of correctly identified plates in the Waggoner CCVT as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: as of the study arm "15,000 ft, 15 min, binocular" assessment was conducted immediately after 15min of hypoxia as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" assessment was conducted immediately after 60 minutes of hypoxia
- Colour vision after hypoxia monocular/binocular D15 [Assessment was conducted immediately after hypoxia and S-Index, C-Index and TES in the Waggoner D15 were collected]
Waggoner D15 was administered in the pressure chamber post hypoxia intervention, thereby the following parameters were collected: - S-Index, C-Index and TES in the Waggoner D15 as of the study arm "15,000 ft, 15 min, binocular" the colour vision tests were performed binocularly as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" the colour vision tests were performed monocularly Time Frame - additional info: as of the study arm "15,000 ft, 15 min, binocular" assessment was conducted immediately after 15min of hypoxia as of the study arms "15,000 ft, 60 min, monocular" and "10,000 ft, 60 min, monocular" assessment was conducted immediately after 60 minutes of hypoxia
- Colour vision without hypoxia monocular/binocular Waggoner CCVT [Assessment was coducted independently of hypoxia three times in a row with a 1 minute break in between each test and the number of correctly identified plates in the Waggoner CCVT was collected]
Waggoner CCVT was administered three times in a row without hypoxia, thereby the following parameters were collected: - the number of correctly identified plates in the Waggoner CCVT as of the study arm "ground control binocular" the colour vision tests were performed binocularly as of the study arm "ground control monocular" the colour vision tests were performed monocularly Time Frame - additional info: - depending on the time the subjects took for each of the colour vision tests, total duration of all 3 test sequences can differ slightly
- Colour vision without hypoxia monocular/binocular D15 [Assessment was coducted independently of hypoxia three times in a row with a 1 minute break in between each test, and S-Index, C-Index and TES in the Waggoner D15 were collected]
Waggoner D15 was administered three times in a row without hypoxia, thereby the following parameters were collected: - S-Index, C-Index and TES in the Waggoner D15 as of the study arm "ground control binocular" the colour vision tests were performed binocularly as of the study arm "ground control monocular" the colour vision tests were performed monocularly Time Frame - additional info: - depending on the time the subjects took for each of the colour vision tests, total duration of all 3 test sequences can differ slightly
Eligibility Criteria
Criteria
Inclusion Criteria:
- volunteers from 18 years old
Exclusion Criteria:
-
cardiovascular, pulmonary, neurological, or ear, nose, and throat disease
-
pregnant or suffering from cold symptoms
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University Hospital Cologne | Cologne | North Rhine-Westphalia | Germany | 50937 |
Sponsors and Collaborators
- Universitätsklinikum Köln
Investigators
- Study Chair: Jochen Hinkelbein, Prof., University Hospital Cologne
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- DRU-COLOR-KOELN