High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity
Study Details
Study Description
Brief Summary
Hypoxia is the most common adverse event during gastrointestinal endoscopes sedated with propofol and sufentanil, especially in obese people. In the present study, high-flow nasal cannula oxygenation will be utilized in order to reduce the incidence of hypoxia among obesity.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Control group Oxygen(up to 6L/min) supplied with a regular nasal catheter |
Device: Regular nasal cannula
Oxygen is supplied with a regular nasal cannula #the flow is up to 6L/min
|
| Experimental: High-flow nasal cannula group Oxygen(up to 60L/min) supplied with high-flow nasal cannula |
Device: High-flow nasal cannula oxygenation
Oxygen is supplied with a high-flow nasal cannula oxygenation device#the flow is up to 60L/min
|
Outcome Measures
Primary Outcome Measures
- The incidence of hypoxia [Patients will be followed for the duration of hospital stay, an expected average of 2 hours]]
(75% ≤ SpO2 < 90% for <60 s)
Secondary Outcome Measures
- The incidence of subclinical respiratory depression [Patients will be followed for the duration of hospital stay, an expected average of 2 hours]
(90% ≤ SpO2 < 95%)
- The incidence of severe hypoxia [Patients will be followed for the duration of hospital stay, an expected average of 2 hours]
(SpO2 < 75% for any duration or 75% < SpO2 < 90% for >/=60 s)
- Other adverse events include other adverse events recorded by tools proposed by the World Society of Intravenous Anesthesia International Sedation Task Force and HFNC supportive oxygen therapy-related adverse events. [Patients will be followed for the duration of hospital stay, an expected average of 2 hours]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
patients undergoing gastrointestinal endoscopes
-
age≥18 years old and ≤70 years old
-
patients or family members signed informed consent form
-
ASA classification I-II
-
BMI≥ 28kg/m²
Exclusion Criteria:
-
Coagulation disorders or a tendency of nose bleeding;
-
An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months;
-
Severe aortic stenosis or mitral stenosis;
-
Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months;
-
Acute myocardial infarction in the last 6 months;
-
Acute arrhythmia (including any tachycardia - or bradycardia) with the fluid of hemodynamics instability;
-
Diagnosed chronic obstructive pulmonary disease or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy);
-
Increased intracranial pressure;
-
ASA classification Ⅲ-Ⅳ ;
-
Mouth, nose, or throat infection;
-
Liver and kidney disease
-
Fever, defined as core body temperature > 37.5℃;
-
Pregnancy, breastfeeding or positive pregnancy test;
-
Emergency procedure;
-
Patients or family members refused to participate
-
Mental disorders and people without civil capacity
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Shanghai Tongji Hospital | Shanghai | Shanghai, China | China | 200065 |
| 2 | Shanghai Oriental Hospital | Shanghai | Shanghai, China | China | 200120 |
| 3 | Renji hospital, School of Medicine, Shanghai Jiaotong University | Shanghai | Shanghai, China | China | 200127 |
Sponsors and Collaborators
- RenJi Hospital
- Shanghai Tongji Hospital, Tongji University School of Medicine
- Shanghai Oriental Hospital, Tongji University School of Medicine
Investigators
- Principal Investigator: Diansan Su, Dr., Renji Hospital, Shanghai Jiaotong University, Shanghai, China
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- HFNOIO