Clincosm LogoSign in Get a demo

Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver Failure

Sponsor
First Affiliated Hospital of Wenzhou Medical University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05909319
Collaborator
(none)
200
Enrollment
24
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function in patients with chronic liver disease. Neutrophils are a major component of the innate immune system, and previous studies have revealed enhanced production of neutrophil extracellular traps (NETs) in ACLF. However, there is still a lack of systematic research on the correlation between NETs and the prognosis of ACLF. We screened NETs related biomarkers through bioinformatics analysis, which play an important role in the diagnosis of ACLF. This study will explore whether these NETs related biomarkers also play an important role in the prognosis of ACLF and further investigate their role in the pathogenesis of ACLF.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    200 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver Failure
    Anticipated Study Start Date :
    Jun 25, 2023
    Anticipated Primary Completion Date :
    Dec 25, 2024
    Anticipated Study Completion Date :
    Jun 25, 2025

    Arms and Interventions

    Arm Intervention/Treatment
    ACLF

    Outcome Measures

    Primary Outcome Measures

    1. mortality [30 days]

      mortality of patients with ACLF

    2. mortality [90 days]

      mortality of patients with ACLF

    3. mortality [half a year]

      mortality of patients with ACLF

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 75 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    1. Patients who meet the diagnostic criteria of Chinese Group on the Study of Severe Hepatitis B (COSSH) for acute-on-chronic liver failure
    Exclusion Criteria:

    1. Age greater than 75 years old

    2. liver cancer

    3. previous liver transplantation

    4. other serious extrahepatic organ diseases

    5. uncontrolled bacterial infections.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • First Affiliated Hospital of Wenzhou Medical University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    First Affiliated Hospital of Wenzhou Medical University
    ClinicalTrials.gov Identifier:
    NCT05909319
    Other Study ID Numbers:
    • 2023-3-14 version V1.0
    First Posted:
    Jun 18, 2023
    Last Update Posted:
    Jun 18, 2023
    Last Verified:
    Apr 1, 2023
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by First Affiliated Hospital of Wenzhou Medical University
    Neutrophil extracellular traps
    Additional relevant MeSH terms:
    Liver Failure
    Hepatic Insufficiency
    End Stage Liver Disease
    Acute-On-Chronic Liver Failure

    Study Results

    No Results Posted as of Jun 18, 2023