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MACOUPLING-CAD: Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)

Sponsor
Institut National de la Santé Et de la Recherche Médicale, France (Other)
Overall Status
Completed
CT.gov ID
NCT02071784
Collaborator
(none)
60
Enrollment
1
Location
27.6
Actual Duration (Months)
2.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Comparison study of parameters derived from mathematical models of neurovascular coupling and obtained using fMRI (Bold signal, ASL and EEG).

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    60 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Other
    Official Title:
    Etude Comparative en Imagerie Par résonnance magnétique et Par Enregistrement électroencéphalographique du Couplage Neurovasculaire Dans l'Angiopathie Cadasil
    Actual Study Start Date :
    Jul 8, 2014
    Actual Primary Completion Date :
    Oct 24, 2016
    Actual Study Completion Date :
    Oct 24, 2016

    Outcome Measures

    Primary Outcome Measures

    1. model-derived parameters of neurovascular coupling [one time point]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 60 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • CADASIL group: typical NOTCH3 mutation, age less than 60 years, rankin score at 0-1, active social insurance
    Exclusion Criteria:
    • MRI contra-indications and use of any treatment known to interfere with neurovascular coupling, pregnancy, lack of informed consent

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 CENIR, Hopital Pitié Salpetriere Paris France 75013

    Sponsors and Collaborators

    • Institut National de la Santé Et de la Recherche Médicale, France

    Investigators

    • Principal Investigator: Hugues Chabriat, MD PhD, INSERM and APHP

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Institut National de la Santé Et de la Recherche Médicale, France
    ClinicalTrials.gov Identifier:
    NCT02071784
    Other Study ID Numbers:
    • C13-62
    • 2014-A00200-47
    First Posted:
    Feb 26, 2014
    Last Update Posted:
    Aug 30, 2021
    Last Verified:
    Aug 1, 2021
    Additional relevant MeSH terms:
    CADASIL
    Dementia, Multi-Infarct

    Study Results

    No Results Posted as of Aug 30, 2021