Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis

• Sponsor: Hillel Yaffe Medical Center (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT01684527
• Collaborator: (none)
• Enrollment: 55
• Location: 1
• Duration (Months): 15
• Patients Per Site Per Month: 3.7

Study Details

Study Description

Brief Summary

The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.

Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.

Condition or Disease	Intervention/Treatment	Phase
Bronchiolitis	Other: Respiratory secretions obtained

Study Design

• Study Type: Observational
• Anticipated Enrollment: 55 participants
• Observational Model: Case-Control
• Time Perspective: Prospective
• Study Start Date: Oct 1, 2012
• Anticipated Primary Completion Date: Jan 1, 2014
• Anticipated Study Completion Date: Jan 1, 2014

Arms and Interventions

Arm	Intervention/Treatment
Children Suffering From Bronchiolitis Respiratory secretions obtained from children suffering from Bronchiolitis	Other: Respiratory secretions obtained
Healthy Children Respiratory secretions obtained from children with no respiratory infection	Other: Respiratory secretions obtained

Outcome Measures

Primary Outcome Measures

1. Number of Immature Myeloid Cells in Respiratory Secretions [Participants will be followed for the duration of hospital stay, an expected average of one week]

   Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A to 2 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Bronchiolitis

Exclusion Criteria:

• Chronic disease

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hillel Yaffe Medical Center	Hadera		Israel	38100

Sponsors and Collaborators

• Hillel Yaffe Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Hillel Yaffe Medical Center
• ClinicalTrials.gov Identifier: NCT01684527
• Other Study ID Numbers: 0039-12-HYMC
• First Posted: Sep 13, 2012
• Last Update Posted: Sep 13, 2012
• Last Verified: Sep 1, 2012

• Additional relevant MeSH terms: Bronchiolitis

Study Results

No Results Posted as of Sep 13, 2012