Immediate Suboptimal Result of Mitral Valve Repair: Late Implications in a Matched Cohort Study
Study Details
Study Description
Brief Summary
Mitral valve regurgitation is a pathology affecting the left atrioventricular valve, conditioning the loss of the normal unidirectionality of the atrioventricular flow and therefore volumetric and pressure overload of the left heart chambers. In industrialized countries, the most common etiology of mitral regurgitation is degenerative mitral disease.
Mitral valve repair surgery represents the gold standard for the treatment of severe degenerative mitral regurgitation. The expected optimal result would be the absence of residual post-procedural mitral regurgitation, even if it is not uncommon to obtain a valve with residual regurgitation of a mild degree. In some cases, for various reasons (technical difficulties, long aortic clamping time, advanced age, high pre-operative surgical risk), a suboptimal result is accepted, i.e. a post-procedural residual mitral regurgitation of even a moderate degree ( 0, 1+, or 2+/4+).
The aim of the present study is to evaluate the late clinical and echocardiographic implications of suboptimal mitral valve repair with a paired-data cohort study
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Suboptimal repair Patients discharged with a residual mitral regurgitation of at least moderate (2+)degree |
Procedure: mitral valve repair
conservative surgery to treat mitral regurgitation. A mitral valve plasty is performed according to the most appropriate technique
|
| Optimal repair Patients discharged with a residual mitral regurgitation of mild (1+) or less degree (trace or 0) |
Procedure: mitral valve repair
conservative surgery to treat mitral regurgitation. A mitral valve plasty is performed according to the most appropriate technique
|
Outcome Measures
Primary Outcome Measures
- Mortality [through study completion, a minimum of 6 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Study group:
-
presence of severe degenerative mitral regurgitation treated by mitral valve repair between 2006 and 2013;
-
presence of moderate residual mitral regurgitation at discharge.
-
Control group:
-
presence of severe degenerative mitral regurgitation treated by mitral valve repair between 2006 and 2013;
-
presence of residual mitral regurgitation of at least mild grade at discharge.
Exclusion Criteria:
- none
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | IRCCS Ospedale San Raffaele | Milan | Italy | 20132 |
Sponsors and Collaborators
- Michele De Bonis
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- SUB-MVR