Immunity Against COVID-19 Vaccine in Healthcare Workers in Argentine
Study Details
Study Description
Brief Summary
Vaccination against coronavirus disease 19 (COVID-19) is an essential primary prevention tool to limit the health and economic effects of the pandemic. Objectives: To determine the variation in the levels of Immunoglobulin G (IgG) antibodies in health workers who received a COVID-19 vaccine.
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Detailed Description
Vaccination against coronavirus disease 19 (COVID-19) is an essential primary prevention tool to limit the health and economic effects of the pandemic. The Ministry of Health of the Nation, designed the "Strategic Plan for vaccination", which the first line being the health workers " The National Administration of Medicines, Food and Medical Technology authorized two emergency vaccines for administration, Sputnik V and Sinopharm vaccine. It is important to evaluate immunogenicity and its correlation with the long-term efficacy and safety profile of this vaccines.
Objectives: To determine the variation in the levels of Immunoglobulin G (IgG) antibodies in health workers who received a COVID-19 vaccine between the time before the first dose, and after 1 month, 6 months and 12 months after the completion of the immunization, depending on whether they have received the Sputnik V vaccine or the Sinopharm vaccine, and correlate the Immunoglobulin G levels with the presence of adverse events and infection with COVID-19 Methodology: Design: observational and analytical study of a prospective cohort of healthcare workers immunized with some COVID-19 vaccine. The presence of IgG will be determined qualitatively and quantitatively. The immunoglobulin G titer in each period will be compared globally and according to the type of vaccine administered.
Study Design
Outcome Measures
Primary Outcome Measures
- To assess the change in the levels of Immunoglobulin G (IgG) antibodies from baseline at 1 month, at 6 months and at 12 months after the completion of the immunization in health workers who received a COVID-19 vaccine [1 year]
To assess the change in the levels of Immunoglobulin G (IgG) antibodies from baseline at 1 month, at 6 months and at 12 months after the completion of the immunization in health workers who received a COVID-19 vaccine
- To correlate the Immunoglobulin G levels with the presence of adverse events and infection with COVID-19 [1 year]
To correlate the Immunoglobulin G levels with the presence of adverse events and infection with COVID-19
Eligibility Criteria
Criteria
Inclusion Criteria:
- Subjects receiving any COVID-19 vaccine.
Exclusion Criteria:
- Subjects who do not agree to participate
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Italiano de Buenos Aires | Buenos Aires | Caba | Argentina | C1199ABB |
Sponsors and Collaborators
- Hospital Italiano de Buenos Aires
Investigators
- Principal Investigator: vanina Pagotto, MSC, Hospital Italiano de Buenos Aires
- Study Chair: Silvana Figar, MSC, Hospital Italiano de Buenos Aires
- Study Director: Hernán Garcia Rivello, Pharm, Hospital Italiano de Buenos Aires
Study Documents (Full-Text)
None provided.More Information
Additional Information:
- World Health Organization. COVID-19 vaccines
- National Drug, Food, and Medical Technology Administration report on the Sputnik V vaccine
- Ministry of Health, Argentina. COVID-19 vaccine
- Ministry of Health, Argentina. Strategic Plan for vaccination against COVID-19 in Argentina
- Ministry of Health of the Government of the City of Buenos Aires. COVID-19 vaccination
- Active surveillance of the sputnik v vaccine in health workers
- Bank of Communication Resources of the Ministry of Health of the Nation. Fifth Vaccine Safety Report
Publications
None provided.- 3913